Method and apparatus for electromagnetic treatment of living systems
Embodiments of the invention include methods of treating a patient with physiological responses arising from an injury or condition, such as post-operative pain, traumatic brain injury, and cognitive defects. These treatment methods can include the steps of generating a pulsed electromagnetic field from a pulsed electromagnetic field source which is configured to simultaneously increase the rate of ion-dependent signaling, such as CaM/NO/cGMP signaling and to minimize the rate of inhibition of such signaling by natural compounds and applying the pulsed electromagnetic field in proximity to a target region affected by the injury or condition for a first treatment interval followed by an inter-treatment period with no electromagnetic field between treatment intervals to reduce a physiological response to the injury or condition.
1. A method for treating a patient, the method comprising:
generating a pulsed electromagnetic field from a pulsed electromagnetic field source wherein the pulsed electromagnetic field consists of a burst having a duration of greater than 2 msec of a 27.12 MHz carrier repeating at between 1 and 20 bursts/sec at an amplitude of between 2 and 10 μT;
applying the pulsed electromagnetic field in proximity to a target region affected by an injury or condition to reduce a physiological response to the injury or condition for a treatment interval that is greater than or equal to 10 minutes;
discontinuing the application of the pulsed electromagnetic field for an inter-treatment period that is greater than six times the treatment interval; and
repeating, for a plurality of times, the steps of generating, applying and discontinuing.
2. The method of claim 1 , further comprising increasing a rate of ion-dependent signaling and minimizing a rate of inhibition of said ion-dependent signaling by natural compounds.
3. The method of claim 1 , further comprising increasing a rate of cyclic guanosine monophosphate (cGMP) signaling and minimizing a rate of inhibition of said cGMP signaling by compounds including phosphodiesterase (PDE).
4. The method of claim 1 , further comprising increasing a rate of cyclic guanosine monophosphate (cGMP) signaling and minimizing a rate of inhibition of said cGMP signaling by compounds including phosphodiesterase (PDE).
5. The method of claim 1 , wherein said repeating comprises repeating for at least 10 times.
6. The method of claim 1 , wherein said repeating comprises repeating the steps of generating, applying and discontinuing, further wherein the pulsed electromagnetic field generated with each repetition is the same.
7. The method of claim 1 , wherein the treatment interval is between 10 and 30 minutes.
8. The method of claim 1 , wherein the inter-treatment period is greater than seven times the treatment interval.
9. The method of claim 1 , wherein the inter-treatment period is between six and 100 times the treatment interval.
10. The method of claim 1 , wherein the inter-treatment period is greater than or equal to 90 minutes.
11. The method of claim 1 , wherein the inter-treatment period is greater than or equal to 180 minutes.
12. The method of claim 1 , wherein the length of a first treatment interval and the length of the inter-treatment period are selected to minimize phosphodiesterase (PDE) production in the patient.
13. The method of claim 1 , further comprising
monitoring the physiological response; and
modifying the pulsed electromagnetic field in response to the monitoring step.
14. The method of claim 1 , further comprising
monitoring the physiological response; and
discontinuing treatment once an acceptable level of the physiological response is reached.
15. The method of claim 1 , further comprising modulating inflammatory cytokines and growth factors at the target region by applying the pulsed electromagnetic field to simultaneously increase the rate of said modulation and to minimize the rate of inhibition of modulation by natural compounds.
16. The method of claim 1 , further comprising accelerating healing of the target region by applying the pulsed electromagnetic field to simultaneously increase a rate of healing and to minimize a rate of inhibition of such healing.
17. The method of claim 1 , wherein applying the pulsed electromagnetic field in proximity to the target region affected by the neurological injury or condition to reduce the physiological response comprises reducing a concentration of interleukin-1beta (IL-1β).
18. The method of claim 17 , wherein the neurodegenerative disease is Parkinson's disease or Alzheimer's disease.
19. The method of claim 1 , wherein the injury or condition is a neurodegenerative disease.
20. The method of claim 1 , wherein the injury or condition is traumatic brain injury (TBI).
21. The method of claim 1 , wherein the injury or condition is post-operative inflammation and pain.
22. A method for treating a patient, the method comprising:
generating a pulsed electromagnetic field from a pulsed electromagnetic field source wherein the pulsed electromagnetic field consists of a burst having a duration of between 2 and 10 msec of a carrier wave repeating at between 1 and 10 bursts/sec at an amplitude of between 3 and 8μT;
applying the pulsed electromagnetic field in proximity to a target region affected by an injury or condition to reduce a physiological response to the injury or condition for a treatment interval that is greater than 10 minutes;
discontinuing the application of the pulsed electromagnetic field for an inter-treatment period that is greater than six times the treatment interval; and
repeating, for a plurality of times, the steps of generating, applying and discontinuing.