Shapeable bone graft substitute and instruments for delivery thereof
View Patent ↗Injectable bone graft material having a biocompatible, resorbable polymer and a biocompatible, resorbable inorganic material exhibiting macro, meso, and microporosities.
1. A flowable body having macro-porosity, meso-porosity, and microporosity comprising:
a homogenous mixture comprising a biocompatible polymer in the amount of about 15% to about 30% by weight and
a material with a size range of about 100 μm to about 4000 μm comprising the oxidation-reduction reaction product of at least one metal cation, at least one oxidizing agent, and at least one oxidizable precursor anion, wherein the reaction product comprises calcium phosphate: said flowable body being imbibed with a fluid, and
wherein homogeneous means that the porosity and pore size distribution is the same throughout the composite.
2. The flowable body of claim 1 having a porosity of about 75%.
3. The flowable body of claim 1 having a porosity of about 80%.
4. The flowable body of claim 1 having a porosity of about 90%.
5. The flowable body of claim 1 , wherein said polymer comprises collagen.
6. The flowable body of claim 1 , wherein said polymer comprises soluble collagen.
7. The flowable body of claim 6 , wherein said soluble collagen has limited cross-links.
8. The flowable body of claim 1 comprising about 15% to about 25% by weight of biocompatible polymer.
9. The flowable body of claim 1 comprising about 15% to about 20% by weight of biocompatible polymer.
10. The flowable body of claim 1 comprising about 20% to about 30% by weight of biocompatible polymer.
11. The flowable body of claim 1 , wherein said fluid is saline, bone marrow aspirate, or blood.
12. The flowable body of claim 1 , wherein said fluid further comprises antibiotics, bone morphogenic proteins, or a therapeutic agent.
13. The flowable body of claim 1 , wherein said reaction product comprises beta tri-calcium phosphate.
14. The flowable body of claim 1 , wherein said calcium phosphate has a size range of about 250 μm to about 2000 μm.
15. The flowable body of claim 1 , wherein said calcium phosphate has a size range of about 250 μm to about 1000 μm.
16. The flowable body of claim 1 , wherein the flowable body has a porosity of at least 70% and wherein about 50% to about 60% of said porosity is macroporosity, about 15% to about 40% of said porosity is mesoporosity, and about 10% to about 15% of said porosity is microporosity.