Rapamycin powders for pulmonary delivery
View Patent ↗The invention provides stable, spray-dried, particle formulations containing rapamycin, or pharmaceutically acceptable salts of rapamycin, which are useful for pulmonary administration to the respiratory tract of a patient for the treatment of disease.
1. A pharmaceutical composition for pulmonary delivery to the respiratory tract of a patient comprising, spray-dried particles of rapamycin and a pharmaceutically acceptable excipient.
2. The pharmaceutical composition of claim 1 , wherein the pharmaceutical excipient comprises one or more of: a phospholipid, a salt, an amino acid or a sugar.
3. The pharmaceutical composition of claim 1 , wherein particles comprise rapamycin in amorphous form.
4. The pharmaceutical composition of claim 1 , wherein the particles comprise rapamycin in crystalline form.
5. The pharmaceutical composition of claim 1 , wherein the particles comprise rapamycin in both crystalline and amorphous forms.
6. A method of delivering rapamycin to the pulmonary system of a patient comprising the steps of:
a) providing a spray-dried particle formulation of claim 1 in a compartment and an inhaler to a patient wherein said powder comprises particles of rapamycin;
b) dispersing the powder by breath actuation of the patient; and
c) delivering the particles to the patient's respiratory system.