Indwelling luminal devices
The invention comprises an indwelling medical device which is capable of delivering a therapeutic agent evenly along the length of the indwelling portion, including the outer wall, of the device.
1. A medical device comprising:
a central tube comprising at least one lumen;
an outer tube concentrically surrounding the central tube such that an annular lumen is defined between the central tube and the outer tube, wherein an outer surface of the outer tube comprises a plurality of grooves extending along a longitudinal axis of the outer tube and configured to transport liquid, gas, or both along a length of the outer surface of the outer tube; and
an outer jacket surrounding the outer tube, wherein the grooves and the outer jacket form a plurality of channels extending along at least a portion of the longitudinal axis of the outer tube,
wherein the outer jacket comprises ePTFE having a permeable microstructure configured to permit a therapeutic agent to perfuse therethrough.
2. The medical device of claim 1 , wherein the central tube, the outer tube, and the outer jacket are configured such that the central tube, the outer tube, and the outer jacket are buoyant in a blood flow when implanted within a vessel.
3. The medical device of claim 1 , wherein the medical device is configured to deliver the therapeutic agent through the permeable microstructure of the outer jacket.
4. The medical device of claim 3 , wherein the therapeutic agent comprises nitrous oxide.
5. The medical device of claim 3 , wherein the therapeutic agent comprises a beneficial drug in the liquid phase.
6. The medical device of claim 1 , wherein the outer jacket is coated with a hydrogel impregnated with a beneficial drug.
7. The medical device of claim 1 , wherein the outer jacket is with coated heparin.
8. The medical device of claim 1 , wherein the central tube comprises ePTFE.
9. The medical device of claim 1 , wherein the medical device is configured to facilitate cleaning while positioned in a patient's vasculature via exposure to an ultrasonic energy source.
10. A medical device comprising:
a central tube comprising at least one lumen;
an outer tube concentrically surrounding the central tube such that an annular lumen is defined between the central tube and the outer tube, wherein an outer surface of the outer tube comprises a plurality of grooves formed in the outer surface of the outer tube without penetrating through an entire thickness of the outer tube; and
an outer jacket surrounding the outer tube, wherein the grooves and the outer jacket form a plurality of channels extending along at least a portion of the longitudinal axis of the outer tube,
wherein the outer jacket comprises ePTFE having a permeable microstructure configured to permit a therapeutic agent to perfuse therethrough.