Topical formulations of tellurium-containing compounds
View Patent ↗Novel formulations of tellurium-containing compounds, which are suitable for topical application, are disclosed. The formulations are characterized by high chemical and physical stability and are easy to handle and use.
1. A method of treating a skin or mucosal membrane ailment caused by HPV in a subject in need thereof, said method comprises administering to said subject a highly stable topical formulation comprising
a tellurium-containing compound in an amount of about 12 to about 35 weight percent of the formulation and
having at least one tellurium dioxo moiety and a pharmaceutically acceptable carrier,
wherein said carrier comprises DMSO and at least one polyethylene glycol solvent; said DMSO is in an amount between about 1% and about 10% by weight of the formulation;
the formulation is chemically and physically stable upon storage at room temperature for at least 30 days;
and said tellurium-containing compound is soluble, dispersible and/or suspendable in said at least one polyethylene glycol solvent at a concentration of about 10 weight percent and is selected from the group consisting of tellurium dioxide (TeO2), a complex of TeO2, a compound having general Formula I:
a compound having general Formula II:
a compound having general Formula III:
and a compound having general Formula IV:
wherein each of t, u and v is independently 0 or 1; each of m and n is independently an integer from 0 to 3; each of j and k is independently an integer from 0 to 4; Y is a cation; X is a halogen atom; and each of R1-R22 is independently selected from the group consisting of hydrogen, hydroxyalkyl, hydroxy, thiohydroxy, alkyl, alkenyl, alkynyl, alkoxy, thioalkoxy, halogen, haloalkyl, carboxy, carbonyl, alkylcarbonylalkyl, carboxyalkyl, acyl, amido, cyano, N-monoalkylamidoalkyl, N,N-dialkylamidoalkyl, cyanoalkyl, alkoxyalkyl, carbamyl, cycloalkyl, heteroalicyclic, sulfonyl, sulfinyl, sulfate, amine, aryl, heteroaryl, phosphate, phosphonate and sulfoneamido.
2. The method of claim 1 , wherein said carrier is selected such that the formulation is stable upon storage for at least 6 months at room temperature.
3. The method of claim 1 , wherein said carrier is selected such that the formulation is stable upon storage at 40° C. for at least 30 days.
4. The method of claim 1 , wherein said at least one polyethylene glycol has an average molecular weight that ranges from about 100 Da to about 10000 Da.
5. The method of claim 1 , wherein a concentration of DMSO is about 5 weight percent of the formulation.
6. The method of claim 1 , wherein said carrier further comprises at least one penetration enhancer and said at least one penetration enhancer is selected from the group consisting of propylene glycol (PG), dimethyl formamide (DMF), allantoin, urazole, N,N-dimethylacetamide (DMA), decylmethylsulfoxide (C10 MSO), polyethylene glycol monolaurate (PEGML), propylene glycol monolaurate (PGML), Phosal, glycerol monolaurate (GML), lecithin, 1-substituted azacycloheptan-2-ones, alcohols, vegetable oil, phosphatidylcholine concentrate (PC), and mixtures thereof.
7. The method of claim 1 , wherein said carrier further comprises at least one surfactant.
8. The method of claim 1 , wherein said formulation further comprising an additional active agent.
9. The method of claim 1 , wherein said tellurium-containing compound has a concentration of ranges from about 15 weight percent to about 20 weight percent.
10. The method of claim 1 , wherein said tellurium-containing compound has general Formula I.
11. The method of claim 1 , wherein said formulation is hydrophilic.
12. The method of claim 1 , wherein said formulation has a viscosity in the range of from about 1,000 cpi to about 1,000,000 cpi at room temperature.
13. The method of claim 1 , wherein said formulation is in a form selected from the group consisting of a cream, an ointment, a paste, a gel, a lotion, a milk, a suspension, a solution, an aerosol, a spray, a foam, a shampoo, a mousse, a serum, a swab, a pledget, a pad, a tincture, a patch and a soap.
14. A method of treating a skin or mucosal membrane ailment caused by HPV in a subject in need thereof, said method comprises administering to said subject a highly stable topical formulation comprising:
AS101, in an amount of about 10 to about 35 weight percent of the formulation; and
a carrier comprising DMSO, in an amount of about 1 to about 10 weight percent of the formulation, and diethylene glycol mononethyl ether,
the carrier selected such that: said AS101 is soluble, dispersible and/or suspendable in the carrier; and the formulation is chemically and physically stable upon storage at room temperature for at least 30 days.
15. The method of claim 14 , wherein DMSO is in an amount of about 5 weight percent of the formulation.