Amino acid derivatives and their uses
View Patent ↗Provided are compounds described by the Formula I: wherein: R 1 is a linear or branched, saturated or unsaturated aliphatic group having from 5 to 22 carbon atoms; R 2 is selected from the group consisting of the functional groups: and salts thereof; n is from 0 to 4; and R 3 is a linear or branched, saturated or unsaturated aliphatic group having from 1 to 6 carbon atoms. Also provided are compositions comprising, and methods of use of, the compounds of the present invention.
1. A compound selected from the group consisting of:
and salts thereof, said salts having an anion X − preferably selected from the group consisting of acetate, benzoate, besylate, bromide, chloride, chlortheophyllinate, citrate, ethandisulfonate, fumarate, gluconate, hippurate, iodide, fluoride, lactate, laurylsulfate, malate, laeate, mesylate, methysulfate, napsylate, nitrate, octadecanoate, oxalate, pamoate, phosphate, polygalacturonate, succinate, sulfate, tartrate, and tosylate.
2. The compound of claim 1 selected from the group consisting of:
and salts thereof, said salts having an anion X − preferably selected from the group consisting of acetate, benzoate, besylate, bromide, chloride, chlortheophyllinate, citrate, ethandisulfonate, fumarate, gluconate, hippurate, iodide, fluoride, lactate, laurylsulfate, malate, laeate, mesylate, methysulfate, napsylate, nitrate, octadecanoate, oxalate, pamoate, phosphate, polygalacturonate, succinate, sulfate, tartrate, and tosylate.
3. The compound of claim 1 selected from the group consisting of:
and salts thereof, said salts having an anion X − preferably selected from the group consisting of acetate, benzoate, besylate, bromide, chloride, chlortheophyllinate, citrate, ethandisulfonate, fumarate, gluconate, hippurate, iodide, fluoride, lactate, laurylsulfate, malate, laeate, mesylate, methysulfate, napsylate, nitrate, octadecanoate, oxalate, pamoate, phosphate, polygalacturonate succinate, sulfate, tartrate, and tosylate.
4. The compound of claim 2 selected from the group consisting of:
5. The compound of claim 1 wherein said compound is
6. The compound of claim 1 wherein said compound is
7. The compound of claim 1 wherein said compound is
8. The compound of claim 1 wherein said compound is
9. The compound of claim 1 wherein said compound is
10. The compound of claim 1 wherein said compound is
11. The compound of claim 1 wherein said compound is
12. A composition comprising a compound of claim 1 and a vehicle wherein said composition is in a form selected form the group consisting of a mouthwash, mouth rinse, mouth spray, toothpaste, tooth gel, sub-gingival gel, mousse, foam, denture care product, dentifrice, lozenge, and chewable tablet.
13. The composition of claim 12 wherein said composition is a mouthwash comprising a carrier comprising water; and at least one surfactant selected from the group consisting of anionic, non-ionic, betaine surfactants and combinations of two or more thereof.
14. The composition of claim 13 further comprising at least one essential oil selected from the group consisting of menthol, thymol, eucalyptol, methyl salicylate, and combinations of two or more thereof.
15. The composition of claim 14 wherein said compound of claim 1 is
16. The composition of claim 14 wherein said compound of claim 1 is
17. The composition of claim 14 wherein said compound of claim 1 is
18. The composition of claim 14 wherein said compound of claim 1 is
19. The composition of claim 14 wherein said compound of claim 1 is
20. A method of inhibiting plaque in the oral cavity comprising contacting a surface of the oral cavity with a compound of claim 1 .