Method for treating, preventing, or reducing the risk of skin infection
View Patent ↗The present invention relates to methods for treating acne and other skin infections caused or mediated by Propionibacterium acnes, Gardnerella vaginalis , or Staphylococcus aureus in a patient with a safe and effective amount of a topically applied oxazolidinone antibiotic compound.
1. A method of treating a skin infection caused or mediated by Propionibacterium acnes or Gardnerella vaginalis in a patient, the method comprising administering a pharmaceutically effective amount of a compound having the formula:
or a pharmaceutically acceptable tautomer, salt, ester, or prodrug thereof.
2. The method according to claim 1 , wherein the compound is a pharmaceutically acceptable salt selected from the group consisting of acetate, ascorbate, benzoate, citrate, esylate, ethanedisulfonate, fumarate, hydrochloride, lactate, maleate, mesylate, phosphate, pyroglutamate, salicylate, succinate, sulfate, tartrate, and tosylate.
3. The method according to claim 1 , wherein the skin infection is caused or mediated by Propionibacterium acnes.
4. The method according to claim 1 , wherein the skin infection is caused or mediated by Gardnerella vaginalis.
5. The method according to claim 1 , wherein the skin infection is selected from acne vulgaris, bacterial conjunctivitis, and bacterial vaginosis.
6. The method according to claim 1 , wherein the skin infection is acne vulgaris.
7. The method according to claim 1 , wherein the skin infection is bacterial vaginosis.
8. The method according to claim 1 , wherein the compound is administered orally, parenterally, or topically.
9. The method according to claim 1 , wherein the compound is administered topically.
10. The method according to claim 1 , wherein the patient is a mammal or domestic animal.
11. The method according to claim 1 , wherein the patient is a human.
12. The method according to claim 1 , wherein the compound is administered once daily or twice daily.
13. The method according to claim 1 , wherein the compound is administered once daily.
14. The method according to claim 1 , wherein the compound is administered twice daily.
15. A method of treating a skin infection caused or mediated by Propionibacterium acnes or Gardnerella vaginalis in a patient, the method comprising administering a pharmaceutically effective amount of a topical formulation comprising one or more dermatologically acceptable carriers and a compound having the formula:
or a pharmaceutically acceptable tautomer, salt, ester, or prodrug thereof.
16. The method according to claim 15 , wherein the skin infection is caused or mediated by Propionibacterium acnes.
17. The method according to claim 15 , wherein the skin infection is caused or mediated by Gardnerella vaginalis.
18. The method according to claim 15 , wherein the skin infection is selected from acne vulgaris, bacterial conjunctivitis, and bacterial vaginosis.
19. The method according to claim 15 , wherein the skin infection is acne vulgaris.
20. The method according to claim 15 , wherein the skin infection is bacterial vaginosis.