Formulations of calcium and phosphate for oral inflammation

1. A liquid composition supersaturated in calcium ions and phosphate ions, the liquid composition being a product of mixing a powder with water in a weight ratio of powder-to-water from about 0.005:1 to about 0.1:1, and wherein the powder comprises: (i) calcium glycerophosphate in an amount of from about 5% w/w to 25% w/w of the powder; (ii) dibasic sodium phosphate anhydrous in an amount of from about 0.5% w/w to about 10% w/w of the powder; (iii) monobasic sodium phosphate anhydrous in an amount of from about 0.3% w/w to about 6% w/w of the powder, and (iv) sodium chloride; and wherein the liquid composition has a pH of from about 6.5 to about 7.5 and is free of visible particles and precipitates.

2. The liquid composition of claim 1 , wherein the dibasic sodium phosphate anhydrous is present in an amount of from about 0.5% w/w to about 4.5% w/w of the powder, and the monobasic sodium phosphate anhydrous is present in an amount of from about 0.3% w/w to about 2.5% w/w of the powder.

3. The liquid composition of claim 1 , wherein the powder further comprises a pH buffering agent.

4. The liquid composition of claim 3 , wherein the pH buffering agent is sodium bicarbonate present in an amount of from about 1% w/w to about 7.5% w/w of the powder.

5. The liquid composition of claim 1 , wherein the powder further comprises silica.

6. The liquid composition of claim 1 , wherein the powder comprises a concentration of calcium that is at least about 20,000 ppm, calculated based on weight percentages of solid components in the powder.

7. The liquid composition of claim 1 , wherein the powder comprises a concentration of phosphate that is at least about 60,000 ppm, calculated based on weight percentages of solid components in the powder.

8. The liquid composition of claim 1 , wherein the powder further comprises one or more of a fluoride salt, an analgesic, an antihistamine, a corticosteroid, an anti-microbial agent, an anti-fungal agent, a flavoring or a preservative.

9. A method for treating an oral injury, an oral inflammation, an oral pain, xerostomia, chronic hyposalivation or complications therefrom in a subject in need of such treatment, the method comprising:

(a) admitting the liquid composition supersaturated in calcium ions and phosphate ions according to claim 1 into the oral cavity of the subject;

(b) moving the composition within the oral cavity;

(c) expelling the composition from the oral cavity of the subject.

10. The method of claim 9 , wherein the subject is in need of treatment for xerostomia or chronic hyposalivation.