3,4-dihydro-2H-isoquinoline-1-one and 2,3-dihydro-isoindol-1-one compounds

1. A Compound of formula (I)

wherein

R 1 , R 2 , R 3 and R 4 are independently selected from H, alkyl and cycloalkyl;

R 5 , R 7 and R 9 are independently selected from H and alkyl;

R 8 (i) is hydrogen and both R 6 and R 9 together are —CH 2 —, and, R 10 and R 11 together are —CH 2 —; or,

(ii) and R 6 , R 9 and R 11 are independently H or alkyl, and R 10 is H; or,

(iii) and R 6 and R 9 are independently H or alkyl and R 10 and R 11 together are —CH 2 —; or,

(iv) and R 11 together are —CH 2 —CH 2 —; and R 6 and R 10 are independently H or alkyl;

A is —C(O)— or —S(O) 2 —;

R 12 is alkyl;

R 13 is halogen or cyano;

R 14 is H, alkylor cycloalkyl;

R 15 is H, alkyl, cycloalkyl or halogen;

m, n and p are independently selected from zero and 1;

w is 1, 2 or 3;

or a pharmaceutically acceptable salt thereof.

2. The compound according to claim 1 , wherein

R 1 and R 2 are alkyl;

R 7 and R 9 are H;

R 8 and R 11 together form —CH 2 —CH 2 —;

R 10 is H or R 10 and R 11 together form —(CH 2 ) w —;

A is —C(O)— or —S(O) 2 —;

R 12 is alkyl;

R 13 is halogen;

R 14 is H or alkyl;

R 15 is H;

m and n are zero;

p is zero or 1;

w is 1 or 2;

or a pharmaceutically acceptable salt thereof.

3. The compound according to claim 1 wherein

R 1 and R 2 are alkyl;

R 7 and R 9 are H;

R 8 and R 11 together form —CH 2 —CH 2 —;

R 10 is H or R 10 and R 11 together form —(CH 2 ) w —;

A is —S(O) 2 —;

R 12 is alkyl;

R 13 is halogen;

R 14 is H or alkyl;

R 15 is H

m and n are zero;

p is zero or 1;

w is 1 or 2;

or a pharmaceutically acceptable salt thereof.

4. The compound according to claim 1 wherein

R 1 and R 2 are alkyl;

R 7 and R 9 are H;

R 8 and R 11 together form —CH 2 —CH 2 —;

R 10 is H;

A is —S(O) 2 —;

R 12 is alkyl;

R 13 is chloro;

R 14 is H;

R 15 is H

m and n are zero;

p is 1;

or a pharmaceutically acceptable salt thereof.

5. The compound according to claim 1 wherein

R 1 and R 2 are methyl;

R 7 and R 9 are H;

R 8 and R 11 together form —CH 2 —CH 2 —;

R 10 is H;

A is —S(O) 2 —;

R 12 is ethyl;

R 13 is chloro;

R 14 is H or alkyl;

R 15 is H

m and n are zero;

p is 1;

or a pharmaceutically acceptable salt thereof.

6. The compound according to claim 1 , wherein A is —S(O) 2 —.

7. The compound according to claim 1 wherein R 1 and R 2 are independently selected from H and alkyl.

8. The compound according to claim 1 wherein R 1 and R 2 are alkyl.

9. The compound according to claim 1 wherein R 1 and R 2 are methyl.

10. The compound according to claim 1 wherein m and n are zero.

11. The compound according to claim 1 wherein p is 1.

12. The compound according to claim 1 wherein w is 1 or 2.

13. The compound according to claim 1 wherein R 5 , R 7 and R 9 are H.

14. The compound according to claim 1 wherein R 9 is H.

15. The compound according to claim 1 , wherein R 12 is methyl, ethyl, propyl or isopropyl.

16. The compound according to claim 1 wherein R 12 is ethyl, propyl or isopropyl.

17. The compound according to claim 1 wherein R 12 is ethyl.

18. The compound according to claim 1 wherein R 13 is chloro.

19. The compound according to claim 1 wherein R 15 is H.

20. The compound according to claim 1 selected from

2-[5-[(1-Acetylazetidin-3-yl)amino]pyridin-3-yl]-5-chloro-3,3-dimethylisoindol-1-one;

2-[5-[(1-Acetylazetidin-3-yl)-methylamino]pyridin-3-yl]-5-chloro-3,3-dimethylisoindol-1-one;

5-Chloro-2-[5-[[(3R or 3S)-1-ethylsulfonylpyrrolidin-3-yl]-methylamino]pyridin-3-yl]-3,3-dimethylisoindol-1-one;

5-Chloro-2-[5-[[(3S or 3R)-1-ethylsulfonylpyrrolidin-3-yl]-methylamino]pyridin-3-yl]-3,3-dimethylisoindol-1-one;

2-[5-[(1-Acetylpiperidin-4-yl)amino]pyridin-3-yl]-5-chloro-3,3-dimethylisoindol-1-one;

5-Chloro-2-[5-[(1-ethylsulfonylpiperidin-4-yl)amino]pyridin-3-yl]-3,3-dimethylisoindol-1-one;

5-Chloro-2-[5-[(1-ethylsulfonylazetidin-3-yl)amino]pyridin-3-yl]-3,3-dimethylisoindol-1-one;

5-Chloro-3,3-dimethyl-2-[5-[(1-methylsulfonylazetidin-3-yl)amino]pyridin-3-yl]isoindol-1-one;

5-Chloro-3,3-dimethyl-2-[5-[(1-propanoylazetidin-3-yl)amino]pyridin-3-yl]isoindol-1-one;

5-Chloro-2-[5-[(1-ethylsulfonylazetidin-3-yl)-methylamino]pyridin-3-yl]-3,3-dimethylisoindol-1-one;

5-Chloro-3,3-dimethyl-2-[5-[methyl-(1-methylsulfonylazetidin-3-yl)amino]pyridin-3-yl]isoindol-1-one;

5-Chloro-3,3-dimethyl-2-[5-[methyl-(1-propanoylazetidin-3-yl)amino]pyridin-3-yl]isoindol-1-one;

5-Chloro-3,3-dimethyl-2-[5-[methyl-(1-propan-2-ylsulfonylazetidin-3-yl)amino]pyridin-3-yl]isoindol-1-one;

5-Chloro-3,3-dimethyl-2-[5-[methyl-(1-propylsulfonylazetidin-3-yl)amino]pyridin-3-yl]isoindol-1-one;

5-Chloro-3,3-dimethyl-2-[5-[methyl-[(3S or 3R)-1-propan-2-ylsulfonylpyrrolidin-3-yl]amino]pyridin-3-yl]isoindol-1-one;

5-Chloro-3,3-dimethyl-2-[5-[methyl-[(3R or 3S)-1-propan-2-ylsulfonylpyrrolidin-3-yl]amino]pyridin-3-yl]isoindol-1-one;

5-Chloro-3,3-dimethyl-2-[5-[methyl-[(3S or 3R)-1-propylsulfonylpyrrolidin-3-yl]amino]pyridin-3-yl]isoindol-1-one;

5-Chloro-3,3-dimethyl-2-[5-[methyl-[(3R or 3 S)-1-propylsulfonylpyrrolidin-3-yl]amino]pyridin-3-yl]isoindol-1-one;

5-Chloro-3,3-dimethyl-2-[5-[methyl-(1-propanoylpiperidin-4-yl)amino]pyridin-3-yl]isoindol-1-one;

5-Chloro-2-[5-[(1-ethylsulfonylpiperidin-4-yl)-methylamino]pyridin-3-yl]-3,3-dimethylisoindol-1-one;

5-Chloro-3,3-dimethyl-2-[5-[methyl-(1-methylsulfonylpiperidin-4-yl)amino]pyridin-3-yl]isoindol-1-one;

5-Chloro-3,3-dimethyl-2-[5-[[(3R or 3 S)-1-methylsulfonylpiperidin-3-yl]amino]pyridin-3-yl]isoindol-1-one;

5-Chloro-3,3-dimethyl-2-[5-[[(3S or 3R)-1-methylsulfonylpiperidin-3-yl]amino]pyridin-3-yl]isoindol-1-one;

5-Chloro-2-[5-[[(3R or 3 S)-1-ethylsulfonylpiperidin-3-yl]amino]pyridin-3-yl]-3,3-dimethylisoindol-1-one;

5-Chloro-2-[5-[[(3S or 3R)-1-ethylsulfonylpiperidin-3-yl]amino]pyridin-3-yl]-3,3-dimethylisoindol-1-one;

5-Chloro-3,3-dimethyl-2-[5-[[(3R or 3 S)-1-propan-2-ylsulfonylpiperidin-3-yl]amino]pyridin-3-yl]isoindol-1-one;

5-Chloro-3,3-dimethyl-2-[5-[[(3S or 3R)-1-propan-2-ylsulfonylpiperidin-3-yl]amino]pyridin-3-yl]isoindol-1-one;

5-Chloro-2-[5-[(1-propanoylazetidin-3-yl)amino]pyridin-3-yl]-3H-isoindol-1-one;

6-Chloro-2-[5-[(1-propanoylazetidin-3-yl)amino]pyridin-3-yl]-3,4-dihydroisoquinolin-1-one;

6-Chloro-2-[5-[(1-ethylsulfonylazetidin-3-yl)amino]pyridin-3-yl]-3,4-dihydroisoquinolin-1-one;

6-Chloro-2-[5-[(1-propan-2-ylsulfonylazetidin-3-yl)amino]pyridin-3-yl]-3,4-dihydroisoquinolin-1-one;

2-[5-[(1-Acetylazetidin-3-yl)amino]pyridin-3-yl]-6-chloro-3,4-dihydroisoquinolin-1-one;

5-Chloro-3-methyl-2-[5-[(1-propanoylazetidin-3-yl)amino]pyridin-3-yl]-3H-isoindol-1-one;

5-Chloro-2-[5-[(1-ethylsulfonylazetidin-3-yl)amino]pyridin-3-yl]-3-methyl-3H-isoindol-1-one;

2-[5-[(2-Acetyl-2-azaspiro[3.3]heptan-6-yl)amino]pyridin-3-yl]-5-chloro-3,3-dimethylisoindol-1-one;

5-Chloro-3,3-dimethyl-2-[5-[(2-propanoyl-2-azaspiro[3.3]heptan-6-yl)amino]pyridin-3-yl]isoindol-1-one;

5-Chloro-2-[5-[(2-ethylsulfonyl-2-azaspiro[3.3]heptan-6-yl)amino]pyridin-3-yl]-3,3-dimethylisoindol-1-one;

5-Chloro-3,3-dimethyl-2-[5-[(2-propan-2-ylsulfonyl-2-azaspiro[3.3]heptan-6-yl)amino]pyridin-3-yl]isoindol-1-one;

(3R or 3S)-5-Chloro-3-methyl-2-[5-[(1-propanoylazetidin-3-yl)amino]-3-pyridyl]isoindolin-1-one;

(3S or 3R)-5-Chloro-3-methyl-2-[5-[(1-propanoylazetidin-3-yl)amino]-3-pyridyl]isoindolin-1-one;

(3R or 3S)-5-Chloro-2-[5-[(1-ethylsulfonylazetidin-3-yl)amino]-3-pyridyl]-3-methyl-isoindolin-1-one;

(3S or 3R)-5-Chloro-2-[5-[(1-ethylsulfonylazetidin-3-yl)amino]-3-pyridyl]-3-methyl-isoindolin-1-one;

2-[5-[(1-Ethylsulfonyl-4-piperidyl)amino]-3-pyridyl]-3,3-dimethyl-1-oxo-isoindoline-5-carbonitrile;

3,3-Dimethyl-1-oxo-2-[5-[(1-propanoyl-4-piperidyl)amino]-3-pyridyl]isoindoline-5-carbonitrile;

3,3-Dimethyl-1-oxo-2-[5-[(1-propanoylazetidin-3-yl)amino]-3-pyridyl]isoindoline-5-carbonitrile;

or a pharmaceutically acceptable salt thereof.

21. The compound according to claim 1 selected from

5-Chloro-2-[5-[(1-ethylsulfonylpiperidin-4-yl)amino]pyridin-3-yl]-3,3-dimethylisoindol-1-one;

5-Chloro-2-[5-[(1-ethylsulfonylazetidin-3-yl)amino]pyridin-3-yl]-3,3-dimethylisoindol-1-one;

5-Chloro-3,3-dimethyl-2-[5-[(1-propanoylazetidin-3-yl)amino]pyridin-3-yl]isoindol-1-one;

5-Chloro-3,3-dimethyl-2-[5-[methyl-[(3S or 3R)-1-propan-2-ylsulfonylpyrrolidin-3-yl]amino]pyridin-3-yl]isoindol-1-one;

5-Chloro-3,3-dimethyl-2-[5-[methyl-[(3R or 3S)-1-propan-2-ylsulfonylpyrrolidin-3-yl]amino]pyridin-3-yl]isoindol-1-one;

5-Chloro-3,3-dimethyl-2-[5-[methyl-[(3R or 3S)-1-propylsulfonylpyrrolidin-3-yl]amino]pyridin-3-yl]isoindol-1-one;

or a pharmaceutically acceptable salt thereof.

22. The compound according to claim 1 , wherein the compound is

5-Chloro-2-[5-[(1-ethylsulfonylpiperidin-4-yl)amino]pyridin-3-yl]-3,3-dimethylisoindol-1-one;

or a pharmaceutically acceptable salt thereof.

23. A process to prepare a compound according to claim 1 comprising

a) the reaction of a compound of formula (II) in the presence of a compound of formula (III);

or

b) the reaction of a compound of formula (IV) in the presence of a compound of formula (V);

wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , R 11 , R 12 , R 13 , R 14 , A, m, n and p are as defined in claim 1 and X in step a) is halogen or triflate and in step b) is halogen.

24. A pharmaceutical composition comprising a compound according to claim 1 and a therapeutically inert carrier.