Contingent cardio-protection for epilepsy patients
View Patent ↗Disclosed are methods and systems for treating epilepsy by stimulating a main trunk of a vagus nerve, or a left vagus nerve, when the patient has had no seizure or a seizure that is not characterized by cardiac changes such as an increase in heart rate, and stimulating a cardiac branch of a vagus nerve, or a right vagus nerve, when the patient has had a seizure characterized by cardiac changes such as a heart rate increase.
1. A medical system comprising:
a first electrode configured to be coupled to a main trunk of a vagus nerve of a patient;
a second electrode configured to be coupled to a cardiac branch of the vagus nerve of the patient;
an electrical signal generator coupled to the first electrode and the second electrode; and
one or more processors configured to:
receive at least one body data stream;
analyze the at least one body data stream using a seizure detection algorithm to determine an epileptic seizure state;
apply a first electrical signal from the electrical signal generator to the main trunk of the vagus nerve using the first electrode as a cathode, based on a first determination that the epileptic seizure state of the patient is a first state where an epileptic seizure is not detected; and
apply a second electrical signal from the electrical signal generator to the cardiac branch of the vagus nerve using the second electrode as the cathode, based on a second determination that the epileptic seizure state of the patient is a second state where the epileptic seizure is detected.
2. The medical system of claim 1 , wherein the second electrical signal is configured to reduce a heart rate of the patient.
3. The medical system of claim 1 , wherein the one or more processors are further configured to apply the first electrical signal based on a programmed duty cycle having at least a programmed on-time and a programmed off-time.
4. The medical system of claim 1 , wherein the one or more processors are further configured to identify an increase in a patient's heart rate and apply the second electrical signal to reduce the patient's heart rate based on the second determination that the epileptic seizure state of the patient is the second state where the epileptic seizure is detected.
5. The medical system of claim 4 , wherein the one or more processors are further configured to sense the patient's heart rate in response to the applied second electrical signal and interrupt the applied second electrical signal if a decrease in the patient's heart rate reaches a lower heart rate threshold.
6. The medical system of claim 4 , wherein the one or more processors are further configured to sense the patient's heart rate in response to the applied second electrical signal and modify the applied second electrical signal to maintain the patient's heart rate between an upper heart rate threshold and a lower heart rate threshold.
7. The medical system of claim 1 , wherein the first electrode is proximal to a brain of the patient relative to the second electrode, wherein the applied first electrical signal utilizes the first electrode as the cathode and the second electrode as an anode, and wherein the applied second electrical signal utilizes the second electrode as the cathode and the first electrode as the anode to reduce a patient's heart rate.
8. The medical system of claim 7 , further comprising a polarity reversal unit capable of reversing a polarity of the first electrode and the second electrode to apply the first electrical signal and the second electrical signal.
9. The medical system of claim 1 , further comprising a polarity reversal unit capable of reversing a polarity of the first electrode and the second electrode to apply the first electrical signal and the second electrical signal.
10. The medical system of claim 1 , further comprising a third electrode and a programmable signal generator where the third electrode is coupled to the main trunk of the vagus nerve and to the programmable signal generator, wherein the one or more processors are further configured to apply the first electrical signal by using the first electrode as the cathode and the third electrode as an anode.
11. The medical system of claim 1 , wherein at least one of the first electrical signal and the second electrical signal is a microburst electrical signal characterized by having a number of pulses per microburst from 2 pulses to about 25 pulses, an interpulse interval of about 2 milliseconds to about 50 milliseconds, an interburst period of at least 100 milliseconds, and a microburst duration of less than about 1 second.
12. The medical system of claim 1 , wherein the one or more processors are further configured to apply both the first electrical signal from the electrical signal generator to the main trunk of the vagus nerve using the first electrode as the cathode and the second electrical signal from the electrical signal generator to the cardiac branch of the vagus nerve using the second electrode as the cathode based on the second determination that the epileptic seizure state of the patient is the second state where the epileptic seizure is detected.
13. The medical system of claim 12 , wherein the one or more processors are further configured to apply the first electrical signal and the second electrical signal to the vagus nerve in at least one of a sequential fashion, a simultaneous fashion, and an alternating-and-repeating fashion.