Treatment for obesity
View Patent ↗The present invention relates to a method for treating or preventing obesity in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of certain carbamate compounds. The invention further relates to methods for reducing body weight and/or reducing food intake in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of certain carbamate compounds.
1. A method for treating pathological eating in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of Formula (I):
or a pharmaceutically acceptable salt or ester thereof;
wherein R is a member selected from the group consisting of alkyl of 1 to 8 carbon atoms, halogen, alkoxy of 1 to 3 carbon atoms, nitro, hydroxy, trifluoromethyl, and thioalkoxy of 1 to 3 carbon atoms;
x is an integer of 0 to 3, with the proviso that R may be the same or different when x is 2 or 3;
R 1 and R 2 are independently selected from the group consisting of hydrogen, alkyl of 1 to 8 carbon atoms, aryl, arylalkyl, cycloalkyl of 3 to 7 carbon atoms; or
R 1 and R 2 can be joined to form a 5 to 7-membered heterocycle that is unsubstituted or substituted with one or more alkyl or aryl groups, wherein the heterocycle can comprise 1 to 2 nitrogen atoms and 0 to 1 oxygen atom, wherein the nitrogen atoms are not directly connected with each other or with the oxygen atom;
wherein the subject reduces body weight, thereby treating the obesity.
2. A method for preventing body weight gain in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of Formula (I):
or a pharmaceutically acceptable salt or ester thereof;
wherein R is a member selected from the group consisting of alkyl of 1 to 8 carbon atoms, halogen, alkoxy of 1 to 3 carbon atoms, nitro, hydroxy, trifluoromethyl, and thioalkoxy of 1 to 3 carbon atoms;
x is an integer of 0 to 3, with the proviso that R may be the same or different when x is 2 or 3;
R 1 and R 2 are independently selected from the group consisting of hydrogen, alkyl of 1 to 8 carbon atoms, aryl, arylalkyl, cycloalkyl of 3 to 7 carbon atoms; or
R 1 and R 2 can be joined to form a 5 to 7-membered heterocycle that is unsubstituted or substituted with one or more alkyl or aryl groups, wherein the heterocycle can comprise 1 to 2 nitrogen atoms and 0 to 1 oxygen atom, wherein the nitrogen atoms are not directly connected with each other or with the oxygen atom;
wherein the subject reduces body weight.
3. The method of claim 1 , wherein x=0.
4. The method of claim 1 , wherein R 1 and R 2 are hydrogen and x=0.
5. The method of claim 1 , wherein the compound of Formula I is an enantiomer of Formula I substantially free of other enantiomers or an enantiomeric mixture wherein one enantiomer of Formula I predominates.
6. The method of claim 5 , wherein the enantiomer of Formula I predominates to the extent of about 90% or greater.
7. The method of claim 5 , wherein the enantiomer of Formula I predominates to the extent of about 98% or greater.
8. The method of claim 5 , wherein the enantiomer of Formula I is an enantiomer of Formula Ia:
or a pharmaceutically acceptable salt or ester thereof.
9. The method of claim 8 , wherein the enantiomer of Formula Ia is the (R) or (D) enantiomer.
10. The method of claim 8 , wherein the enantiomer of Formula Ia is the (S) or (L) enantiomer.
11. The method of claim 8 , wherein the enantiomer of Formula Ia predominates to the extent of about 90% or greater.
12. The method of claim 8 , wherein the enantiomer of Formula Ia predominates to the extent of about 98% or greater.
13. The method of claim 5 , wherein the enantiomer of Formula I substantially free of other enantiomers is the compound of Formula Ib or an enantiomeric mixture wherein the compound of Formula Ib predominates:
or a pharmaceutically acceptable salt or ester thereof.
14. The method of claim 13 , wherein the compound of Formula Ib predominates to the extent of about 90% or greater.
15. The method of claim 13 , wherein the compound of Formula Ib predominates to the extent of about 98% or greater.
16. The method of claim 1 , wherein the effective amount of the compound of Formula I is from about 0.01 mg/kg/dose to about 150 mg/kg/dose.
17. The method of claim 1 , wherein the effective amount of the compound of Formula I is from about 1 mg/day to about 7000 mg/day.
18. The method of claim 1 , wherein the compound of Formula I is administered orally.
19. The method of claim 1 , wherein the compound of Formula I is administered in the form of a capsule or tablet.
20. The method of claim 1 , wherein the compound of Formula I is administered in the form of a capsule at a dose of about 10 mg to about 1000 mg without any excipients.