ST-246 liquid formulations and methods
View Patent ↗The present invention provides for a novel liquid formulation for solubilizing poorly soluble ST-246 in cyclodextrins and a novel process of making the formulation.
1. A method of treating orthopoxvirus infections and/or eczema vaccinatum comprising administering to a subject in need thereof a liquid pharmaceutical formulation comprising a therapeutically effective amount of ST-246 and hydroxypropyl-β-cyclodextrin and/or sulfobutyl-ether-β-cyclodextrin, and further comprising one or more pharmaceutically acceptable ingredients.
2. The method of claim 1 , wherein said liquid formulation is administered by parenteral administration.
3. The method of claim 1 , wherein said liquid formulation is administered by oral administration.
4. The method of claim 1 , wherein said liquid formulation is administered by topical administration.
5. The method of claim 1 , wherein said liquid formulation is administered by intravenous administration.
6. The method of claim 5 , wherein about 50 to about 500 mg of ST-246 is infused per single session of intravenous administration.
7. The method of claim 5 , wherein about 200 to about 400 mg of ST-246 is infused per single session of intravenous administration.
8. The method of claim 5 , wherein about 300 mg of ST-246 is infused per single session of intravenous administration.
9. The method of claim 5 , wherein said treatment is carried out for a period ranging from about 7 to about 30 days.
10. The method of claim 5 , wherein said treatment is carried out for a period ranging from about 7 to about 15 days.
11. The method of claim 5 , wherein the duration of each session of intravenous administration is from about 2 to about 24 hours.
12. The method of claim 5 , wherein said treatment is carried out continuously over the course of treatment at a dosage of about 50 to about 500 mg of ST-246 per day.
13. The method of claim 5 , wherein said intravenous administration is carried out during two sessions per day.
14. The method of claim 13 , wherein the duration of each session is from about 2 to about 12 hours.