Methods of treating fibrosis
View Patent ↗Disclosed are methods of treating fibrosis in a patient, comprising administering to a patient in need thereof a therapeutically effective amount of an ACK inhibitor (e.g., a BTK inhibitor, such as for example an irreversible BTK inhibitor, such as for example, ibrutinib).
1. A method of treating pancreatic cancer in a pancreatic cancer patient having pancreatic fibrosis, comprising administering to the patient a therapeutically effective amount of a compound which is (R)-1-(3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one (ibrutinib), of the structure:
2. The method of claim 1 , wherein the pancreatic cancer is pancreatic ductal adenocarcinoma.
3. A method of treating pancreatic cancer in a pancreatic cancer patient having pancreatic fibrosis, comprising administering to the patient a therapeutically effective amount of a compound which is (R)-1-(3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one (ibrutinib), of the structure:
and a therapeutic amount of gemcitabine.
4. The method of claim 3 , wherein the pancreatic cancer is pancreatic ductal adenocarcinoma.
5. The method of claim 3 , wherein survival of the patient is increased as compared to administration of gemcitabine alone.
6. The method of claim 3 , wherein pancreatic fibrosis is reduced.