IP Library › Granted Patent US 9,458,166
Granted Patent B2
US 9,458,166 · App. 14/959,538 · Granted Oct 4, 2016

Oligomer-opioid agonist conjugates

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Quick Facts
Patent No.
US 9,458,166
App. No.
14/959,538
Granted
Oct 4, 2016
Kind
B2
Abstract

The invention provides compounds that are chemically modified by covalent attachment of a water-soluble oligomer. A compound of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from those of the compound not attached to the water-soluble oligomer.

Claims (7)

1. A method of preparing a compound of Formula C:

comprising reacting α-6-hydroxycodone with an activated sulfonate ester of methoxy-terminated poly(ethylene glycol) to form the compound of Formula C:

wherein n is 1, 2, 3, 4, 5, 6, 7, or 9.

2. The method of claim 1 , wherein the α-6-hydroxycodone is produced by reduction of oxycodone.

3. The method of claim 1 , wherein the reaction is carried out at a temperature from 60° C. to 80° C.

4. The method of claim 1 , wherein the reaction is carried out in a mixture of toluene and DMF.

5. The method of claim 1 , wherein the reaction is carried out in the presence of NaH.

Assignments (8)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 9, 2023
From: INHERIS BIOPHARMA, INC.
To: NEKTAR THERAPEUTICS
Reel/Frame 062313/0501 →
RELEASE OF SECURITY INTEREST Recorded Apr 17, 2020
From: TC LENDING, LLC, AS COLLATERAL AGENT
To: NEKTAR THERAPEUTICS
Reel/Frame 053180/0009 →
RELEASE OF SECURITY INTEREST Recorded Apr 17, 2020
From: TC LENDING, LLC, AS COLLATERAL AGENT
To: INHERIS BIOPHARMA, INC.
Reel/Frame 052435/0062 →
CHANGE OF NAME Recorded Nov 15, 2019
From: INHERIS PHARMACEUTICALS, INC.
To: INHERIS BIOPHARMA, INC.
Reel/Frame 051038/0585 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 28, 2019
From: NEKTAR THERAPEUTICS
To: INHERIS PHARMACEUTICALS, INC.
Reel/Frame 050846/0461 →
SECURITY INTEREST Recorded Oct 28, 2019
From: INHERIS PHARMACEUTICALS, INC.
To: TC LENDING, LLC, AS COLLATERAL AGENT
Reel/Frame 050846/0940 →
SECURITY INTEREST Recorded Mar 15, 2016
From: NEKTAR THERAPEUTICS
To: TC LENDING, LLC, AS A COLLATERAL AGENT
Reel/Frame 037990/0511 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 21, 2016
From: RIGGS-SAUTHIER, JENNIFER; DENG, BO-LIANG; RILEY, TIMOTHY A.
To: NEKTAR THERAPEUTICS
Reel/Frame 037554/0055 →