Oligomer-opioid agonist conjugates

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Quick Facts

Patent No.: US 9,512,135
App. No.: 14/959,604
Granted: Dec 6, 2016
Kind: B2

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Abstract

The invention provides compounds that are chemically modified by covalent attachment of a water-soluble oligomer. A compound of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from those of the compound not attached to the water-soluble oligomer.

Claims (11)

1. A compound having the formula:

wherein n is an integer having a value of from 1 to 9, and pharmaceutically acceptable salts thereof.

2. The compound of claim 1 , wherein n is 1.

3. The compound of claim 1 , wherein n is 2.

4. The compound of claim 1 , wherein n is 3.

5. The compound of claim 1 , wherein n is 4.

6. The compound of claim 1 , wherein n is 5.

7. The compound of claim 1 , wherein n is 6.

8. The compound of claim 1 , wherein n is 7.

9. The compound of claim 1 , wherein n is 8.

10. The compound of claim 1 , wherein n is 9.