PRODRUGS OF GABA ANALOGS, COMPOSITIONS AND USES THEREOF
The present invention provides prodrugs of GABA analogs, pharmaceutical compositions of prodrugs of GABA analogs and methods for making prodrugs of GABA analogs. The present invention also provides methods for using prodrugs of GABA analogs and methods for using pharmaceutical compositions of prodrugs of GABA analogs for treating or preventing common diseases and/or disorders.
1 . A compound of Formula (I):
or a pharmaceutically acceptable salt thereof, wherein
n is 0;
each of R1, R3, R6 and R7 is hydrogen;
Y is oxygen; and
R4 and R5, together with the carbon atom to which they are attached, form a cyclobutyl ring that is substituted with an ethanyl-substituted C 2 -C 4 alkenyl moiety.
2 . The compound of claim 1 , wherein the ethanyl-substituted C 2 -C 4 alkenyl moiety is an ethanyl-substituted propenyl moiety.
3 . The compound of claim 2 , comprising a pharmaceutically acceptable salt.
4 . The compound of claim 3 , wherein the salt is a benzene sulfonic acid salt.
5 . A pharmaceutical composition comprising a therapeutically effective amount of a compound of claim 1 .
6 . A method for treating epilepsy, depression, anxiety, psychosis, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, panic, pain, inflammatory disease, insomnia, gastrointestinal disorders or ethanol withdrawal syndrome in a patient, comprising administering to a patient in need of such treatment a therapeutically effective amount of a compound of claim 1 .
7 . The method of claim 6 , comprising treating pain.
8 . The method of claim 7 , comprising treating neuropathic pain.
9 . The method of claim 6 , for treating anxiety.
10 . The method of claim 6 , for treating epilepsy.
11 . A compound of Formula (XIII):
wherein each of R3 and R6 is hydrogen;
R4 and R5, together with the carbon atom to which they are attached, form a cyclobutyl ring that is substituted with an ethanyl-substituted C2-C4 alkenyl moiety.
12 . The compound of claim 11 , comprising a pharmaceutically acceptable salt.
13 . The compound of claim 12 , wherein the salt is a benzene sulfonic acid salt.
14 . A compound of Formula (XIII):
wherein each of R3 and R6 is hydrogen;
R4 and R5, form a substituted C4-C7 cycloalkyl that is a bicyclic.
15 . The compound of claim 14 , comprising a pharmaceutically acceptable salt.
16 . The compound of claim 14 , wherein the salt is a benzene sulfonic acid salt.