Apparatus and method for manipulating stomach tissue and treating gastroesophageal reflux disease

1. A method of restoring a flap of a gastroesophageal flap valve associated with a stomach, comprising:

providing a medical device for forming a folded flap of stomach tissue and placing a first fastener in the folded flap of stomach tissue;

first, inflate the stomach to a first pressure;

after inflating the stomach to the first pressure, aligning a portion of the medical device with the Z-line;

second, after aligning a portion of the medical device with the Z-line, inflate the stomach to a second pressure that is higher than the first pressure;

the medical device having a cable at a distal end of the medical device, and a coil at a distal end of the cable;

after inflating the stomach to the second pressure, gripping stomach tissue with the coil from within the stomach at a point displaced from the esophageal opening of the stomach;

deflating the stomach;

after deflating the stomach, pulling the cable and the gripped stomach tissue into a mold to form the folded flap of stomach tissue; and

third, after pulling the gripped stomach tissue into the mold, inflate the stomach to a pressure sufficient to provide a good view of the folded flap of stomach tissue and deploying the first fastener through the folded flap of stomach tissue.

2. The method of claim 1 , wherein the stomach is associated with an esophagus and wherein the method further comprises gripping a wall of the esophagus prior to gripping the stomach.

3. The method of claim 2 , wherein the step of gripping a wall of the esophagus includes gripping the wall of the esophagus with a vacuum.

4. The method of claim 1 , further comprising repeating the inflating, aligning, gripping, deflating, pulling, and deploying steps for forming another folded flap of stomach tissue and deploying a second fastener displaced from the first fastener.

5. The method of claim 1 , further comprising releasing the grip on the stomach tissue after the first fastener is deployed.

6. The method of claim 1 , further comprising, before the gripping step, visualizing the stomach from within the stomach.

7. The method of claim 6 , wherein the stomach is associated with an esophagus and wherein the method further comprises gripping a wall of the esophagus after inflating the stomach to the first pressure and prior to gripping the stomach.

8. The method of claim 6 , further comprising repeating the inflating, aligning, inflating, visualizing, gripping, deflating, pulling, and deploying steps for forming another folded flap of stomach tissue and deploying a second fastener displaced from the first fastener.

9. The method of claim 8 , further comprising measuring from the folded flap of stomach tissue prior to repeating the gripping step.

10. The method of claim 1 , further comprising, before the gripping step and before the step of increasing the inflation pressure within the stomach to the second pressure, visualizing the stomach from within the stomach.

11. The method of claim 10 , wherein the stomach is associated with an esophagus and wherein the method further comprises gripping a wall of the esophagus after inflating the stomach to the first pressure and prior to gripping the stomach.

12. The method of claim 10 , further comprising repeating the inflating, aligning, inflating, visualizing, increasing, gripping, deflating, pulling, and deploying steps for forming another folded flap of stomach tissue and deploying a second fastener displaced from the first fastener.

13. The method of claim 12 , further comprising measuring from the folded flap of stomach tissue prior to repeating the gripping step.