Medical devices for delivering a bioactive to a point of treatment and methods of making medical devices
View Patent ↗Methods of making medical devices are described. A method of making a medical device for delivering a bioactive includes preparing a suitable solution comprising the bioactive; placing a vessel containing the solution over a substrate comprising a biocompatible foam and defining open cells; initiating flow of the solution from the vessel and toward the substrate such that the solution exits the vessel and contacts the substrate; and maintaining flow of the solution for an amount of time sufficient to achieve a desired volume of the solution within the substrate. Medical devices made by the methods are also described.
1. A method of making a medical device for delivering a bioactive, said method comprising:
preparing a suitable water-based solution comprising said bioactive;
placing a vessel containing the solution over a substrate comprising a biocompatible foam formed of an expanded natural material and defining a plurality of cells;
initiating flow of the solution from the vessel and toward the substrate such that the solution exits the vessel and contacts the substrate;
massaging the substrate to facilitate entry of the solution into the substrate; and
maintaining flow of the solution for an amount of time sufficient to achieve a desired volume of the solution within the substrate.
2. The method of claim 1 , wherein the substrate comprises a biocompatible foam formed of an expanded collagenous material.
3. The method of claim 1 , wherein the substrate comprises a biocompatible foam formed of an expanded extracellular matrix material.
4. The method of claim 1 , wherein the substrate comprises a biocompatible foam formed of expanded small intestine submucosa.
5. The method of claim 1 , wherein the massaging the substrate comprises contacting a portion of the substrate that contains the solution with a finger and moving the finger across the substrate while maintaining contact between the finger and the substrate.
6. The method of claim 1 , wherein the massaging comprises contacting a portion of the substrate that contains the solution with a mechanical apparatus and initiating relative movement between the mechanical apparatus and substrate while maintaining contact between the substrate and mechanical apparatus.
7. The method of claim 1 , wherein the massaging is performed while the maintaining flow is performed.
8. The method of claim 1 , wherein the massaging is performed after all other steps have been completed.
9. The method of claim 1 , further comprising drying the substrate.
10. The method of claim 9 , wherein the drying is performed while the massaging is being performed.
11. The method of claim 9 , wherein the drying is performed after all other steps have been completed.
12. The method of claim 1 , further comprising applying a polymer onto the substrate.
13. The method of claim 12 , wherein the applying is performed after the massaging is completed.
14. The method of claim 13 , wherein the applying comprises dipping the substrate into a solution containing the polymer.
15. The method of claim 14 , wherein the applying is performed until the entire substrate is covered by the polymer.
16. A method of making a medical device for delivering a bioactive, said method comprising:
preparing a suitable water-based solution comprising said bioactive;
placing a vessel containing the solution over a substrate comprising a biocompatible foam formed of an expanded natural material and defining a plurality of cells;
initiating flow of the solution from the vessel and toward the substrate such that the solution exits the vessel and contacts the substrate;
massaging the substrate to facilitate entry of the solution into the substrate;
maintaining flow of the solution for an amount of time sufficient to achieve a desired volume of the solution within the substrate;
drying the substrate; and
applying a polymer onto the substrate.
17. The method of claim 16 , wherein the substrate comprises a biocompatible foam formed of an expanded collagenous material.
18. The method of claim 16 , wherein the substrate comprises a biocompatible foam formed of an expanded extracellular matrix material.
19. The method of claim 16 , wherein the substrate comprises a biocompatible foam formed of expanded small intestine submucosa.
20. A method of making a medical device for delivering a bioactive, said method comprising:
preparing a suitable water-based solution comprising said bioactive;
placing a vessel containing the solution over a substrate comprising a biocompatible foam formed of an expanded natural material and defining a plurality of cells;
initiating flow of the solution from the vessel and toward the substrate such that the solution exits the vessel and contacts the substrate;
massaging the substrate to facilitate entry of the solution into the substrate;
maintaining flow of the solution for an amount of time sufficient to achieve a desired volume of the solution within the substrate;
drying the substrate; and
applying a polymer onto the substrate after the after the steps of massaging the substrate and drying the substrate are completed.