Medical devices for local bioactive delivery

1. A medical device for delivering a bioactive, said medical device comprising:

a first biodegradable layer having a first peripheral edge, first and second opposing surfaces, and a first peripheral portion including portions of the first and second opposing surfaces and a portion of the first peripheral edge, the first layer having a first area;

a second biodegradable layer having a second peripheral edge, third and fourth opposing surfaces, and a second peripheral portion including portions of the third and fourth opposing surfaces and a portion of the second peripheral edge, the second layer having a second area that is less than the first area;

the first and second biodegradable layers positioned such that the second surface faces the third surface;

the first peripheral portion folded over the second peripheral portion to form a triple laminate structure in which a portion of the second surface contacts a portion of the fourth surface; and

a bioactive disposed between the first and second biodegradable layers.

2. The medical device of claim 1 , wherein the first and second biodegradable layers are formed of the same material.

3. The medical device of claim 1 , wherein the first and second biodegradable layers are formed of different materials.

4. The medical device of claim 3 , wherein one of the first and second biodegradable layers is formed of a first biodegradable material and the other of the first and second biodegradable layers is formed of a second biodegradable material; and

wherein the first biodegradable material degrades relatively quickly in vivo and the second biodegradable material degrades relatively slowly in vivo.

5. The medical device of claim 1 , wherein one of the first and second biodegradable layers is formed of a cellulose material.

6. The medical device of claim 5 , wherein the cellulose material comprises carboxymethyl cellulose.

7. The medical device of claim 5 , wherein the cellulose material comprises Hydroxylpropyl methyl cellulose.

8. The medical device of claim 1 , wherein the first biodegradable layer is secured to the second biodegradable layer.

9. The medical device of claim 1 , wherein the first and second biodegradable layers cooperatively define a cavity between the first and second biodegradable layers.

10. The medical device of claim 9 , wherein the bioactive is disposed in the cavity.

11. The medical device of claim 10 , wherein the bioactive comprises a powder.

12. The medical device of claim 11 , wherein the bioactive occupies the entire space of the cavity.

13. The medical device of claim 11 , wherein the cavity is partially filled with the bioactive.

14. The medical device of claim 1 , wherein the first biodegradable layer includes a main portion and first and second tabs extending from the main portion.

15. The medical device of claim 14 , wherein the first peripheral portion comprises the first and second tabs.

16. The medical device of claim 14 , wherein the first peripheral portion consists of the first and second tabs.

17. The medical device of claim 1 , wherein the triple laminate structure extends along only a single outer edge of said medical device.

18. The medical device of claim 1 , wherein the triple laminate structure extends continuously along the entire outer edge of said medical device.

19. A medical device for delivering a bioactive, said medical device comprising:

a first biodegradable layer having a first peripheral edge, first and second opposing surfaces, and a first peripheral portion including portions of the first and second opposing surfaces and the entire first peripheral edge, the first layer having a first area;

a second biodegradable layer having a second peripheral edge, third and fourth opposing surfaces, and a second peripheral portion including portions of the third and fourth opposing surfaces and the entire second peripheral edge, the second layer having a second area that is less than the first area;

the first and second biodegradable layers positioned such that the second surface faces the third surface;

the first peripheral portion folded over the second peripheral portion to form a triple laminate structure extending continuously along the entire outer edge of said medical device such that a portion of the second surface contacts a portion of the fourth surface; and

a bioactive disposed between the first and second biodegradable layers.

20. A medical device for delivering a bioactive, said medical device comprising:

a first biodegradable layer having a first peripheral edge, first and second opposing surfaces, and a first peripheral portion including portions of the first and second opposing surfaces and the entire first peripheral edge, the first layer having a first area;

a second biodegradable layer having a second peripheral edge, third and fourth opposing surfaces, and a second peripheral portion including portions of the third and fourth opposing surfaces and the entire second peripheral edge, the second layer having a second area that is less than the first area;

the first and second biodegradable layers positioned such that the second surface faces the third surface and the first and second biodegradable layers cooperatively define a cavity between the first and second biodegradable layers;

the first peripheral portion folded over the second peripheral portion to form a triple laminate structure extending continuously along the entire outer edge of said medical device such that a portion of the second surface contacts a portion of the fourth surface; and

a bioactive disposed in the cavity between the first and second biodegradable layers.