IP Library › Granted Patent US 9,499,583
Granted Patent B2
US 9,499,583 · App. 14/977,451 · Granted Nov 22, 2016

Antibacterial antisense oligonucleotide and method

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Quick Facts
Patent No.
US 9,499,583
App. No.
14/977,451
Granted
Nov 22, 2016
Kind
B2
Abstract

A method for enhancing, by at least 10 fold, the antibacterial activity of an antisense oligonucleotide composed of morpholino subunits linked by phosphorus-containing intersubunit linkages. The method includes one or both of: conjugating an arginine-rich carrier to a 3′ or 5′ end of the oligonucleotide and modifying the oligonucleotide to contain 20%-50% intersubunit linkages that are positively charged at physiological pH. Also disclosed is an antisense oligonucleotide having enhanced antibacterial activity by virtue of one or both modifications.

Claims (3)

1. A peptide of formula:

wherein R is selected from H and acetyl.

2. The peptide of claim 1 , wherein R is acetyl.

Assignments (3)
SECURITY INTEREST Recorded May 7, 2025
From: SAREPTA THERAPEUTICS, INC.
To: JPMORGAN CHASE BANK, N.A. AS ADMINISTRATIVE AGENT
Reel/Frame 071218/0445 →
CHANGE OF NAME Recorded Oct 12, 2016
From: AVI BIOPHARMA, INC.
To: SAREPTA THERAPEUTICS, INC.
Reel/Frame 040332/0942 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 12, 2016
From: WELLER, DWIGHT D.; GELLER, BRUCE L.; IVERSEN, PATRICK L.; TILLEY, LUCAS D.; HASSINGER, JED N.
To: AVI BIOPHARMA, INC.
Reel/Frame 039997/0416 →