IP Library Patent Application 14978230
Patent Application
App. No. 14/978,230

NASAL DELIVERY METHOD

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Quick Facts
Patent No.
US None
App. No.
14/978,230
Abstract

A delivery device ( 20, 22 ) for and a method of delivering a substance to the nasal airway ( 1 ) of a subject, in particular the posterior region of the nasal airway, the delivery device comprising: a closure unit for causing the closure of the oropharyngeal velum of the subject; and a delivery unit for delivering a gas flow entraining a substance to one of the nostrils of the subject at such a driving pressure as to flow around the posterior margin of the nasal septum and out of the other nostril of the subject, wherein the delivery unit comprises a nosepiece ( 30, 40, 58, 82, 102, 132 ) which includes an outlet through which the gas flow is in use delivered to the one nostril and a sealing member for sealing the one nostril to the outlet such as in use to prevent the escape of the gas flow through the one nostril.

Claims (30)

1 - 34 . (canceled)

35 . A method of irrigating the nasal airway of a subject, comprising:

sealing a first nostril of a subject to an outlet of a delivery unit;

closing the oropharyngeal velum of the subject; and

delivering an irrigating agent through the outlet of the delivery unit at such a driving pressure as to flow around the posterior margin of the nasal septum and out of the other, second nostril of the subject.

36 . The method of claim 35 , further comprising:

sealing the second nostril of the subject to the outlet of the delivery unit;

closing the oropharyngeal velum of the subject; and

delivering an irrigating agent through the outlet of the delivery unit at such a driving pressure as to flow around the posterior margin of the nasal septum and out of the first nostril of the subject.

37 . The method of claim 35 , wherein the velum closure is provided by exhalation by the subject.

38 . The method of claim 35 , wherein the irrigating agent is delivered in an exhalation flow.

39 . The method of claim 35 , wherein the irrigating agent is delivered by actuation of a supply unit.

40 . The method of claim 39 , wherein the supply unit is actuated by the exhalation flow of the subject.

41 . The method of claim 35 , further comprising:

providing a flow resistance to the nasal airway of the subject so as to maintain a dynamic positive pressure in the nasal airway of the subject.

42 . The method of claim 41 , wherein the dynamic positive pressure is of sufficient magnitude as to force open at least one of the auditory tubes or the sinus tubes.

43 . The method of claim 41 , wherein the dynamic positive pressure is at least 5 cm H 2 O.

44 . The method of claim 41 , wherein the dynamic positive pressure is at least 50 cm H 2 O.

45 . The method of claim 41 , further comprising:

providing at least one of a visual or an audible signal when a predetermined dynamic positive pressure is achieved in the nasal airway of the subject.

46 . The method of claim 35 , wherein the irrigating agent comprises a liquid.

47 . The method of claim 46 , wherein the irrigating agent comprises saline.

48 . The method of claim 46 , wherein the irrigating agent contains oils or herbs.

49 . The method of claim 35 , wherein the irrigating agent is delivered in combination with a cleansing agent.

50 . The method of claim 35 , in the treatment of nasal inflammation.

51 . The method of claim 35 , in the treatment of rhinitis.

52 . The method of claim 35 , in the treatment of nasal polyps.

53 . The method of claim 1 , in the treatment of hypertrophic adenoids.

54 . The method of claim 35 , in the treatment of secretory otitis media.

55 . The method of claim 35 , in the treatment of reduced olfaction.

Assignments (3)
RELEASE OF SECURITY AGREEMENT RECORDED AT REEL 044976 FRAME 0505 Recorded Sep 13, 2019
From: ATHYRIUM OPPORTUNITIES III ACQUISITION LP
To: OPTINOSE AS
Reel/Frame 050371/0894 →
SECURITY INTEREST Recorded Dec 29, 2017
From: OPTINOSE AS
To: ATHYRIUM OPPORTUNITIES III ACQUISITION LP
Reel/Frame 044976/0505 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 14, 2017
From: DJUPESLAND, PER GISLE
To: OPTINOSE AS
Reel/Frame 042709/0833 →