BONE GRAFT MATERIALS AND METHODS
Compositions, materials, methods and kits for bone grafting are described. In some embodiments, a bone graft composition includes about 15% to about 20% by weight collagen, about 55% to about 70% by weight bioactive glass, and about 15% to about 30% by weight a calcium phosphate. The bioactive glass and the calcium phosphate together are about 80% to about 85% by weight of the bone graft composition. In some embodiments, a bone graft composition includes a collagen matrix and a plurality of bioactive glass particulates dispersed throughout the collagen matrix. The collagen matrix is about 20% to about 60% by weight of the bone graft composition, and the bioactive glass is about 40% to about 80% of the bone graft composition. In some embodiments, a majority of the bioactive glass particulates are about 53 μm to about 425 μm in size.
1 . A bone graft composition comprising:
about 15% to about 20% by weight collagen;
about 55% to about 70% by weight bioactive glass, the bioactive glass including particles within a range of about 53 μm to about 425 μm in size, at least 85% of the bioactive glass particles being within a range of 212 μm to 425 μm in size; and
about 15% to about 30% by weight calcium phosphate.
2 . The bone graft composition of claim 1 , wherein the bioactive glass particles and the calcium phosphate together are about 80% to about 85% by weight of the bone graft composition.
3 . The bone graft composition of claim 1 , wherein the collagen is type I collagen.
4 . The bone graft composition of claim 1 , wherein the bioactive glass includes particles having a smooth surface.
5 . The bone graft composition of claim 1 , wherein the calcium phosphate comprises about 40% to about 80% tricalcium phosphate and about 20% to about 60% hydroxyapatite.
6 . The bone graft composition of claim 5 , further comprising about 15% by weight type I collagen, about 55% to about 65% by weight bioactive glass, and about 20% to about 30% by weight calcium phosphate.
7 . The bone graft composition of claim 6 , wherein a weight ratio of the collagen to the bioactive glass to the calcium phosphate is about 15%:55%:30%, respectively.
8 . The bone graft composition of claim 6 , wherein a weight ratio of the collagen to the bioactive glass to the calcium phosphate is about 15%:60%:25%, respectively.
9 . The bone graft composition of claim 6 , wherein a weight ratio of the collagen to the bioactive glass to the calcium phosphate is about 15%:65%:20%, respectively.
10 . The bone graft composition of claim 1 , wherein the bioactive glass is 45S5 glass.
11 . A bone graft composition, comprising:
a collagen carrier; and
a bioactive glass dispersed throughout the collagen carrier, the bioactive glass including particles having a size within a range of about 53 μm to about 425 μm, at least 85% of the bioactive glass particles having a size within a range of 212 μm to 425 μm;
wherein the collagen carrier is about 20% to about 60% by weight of the bone graft composition and the bioactive glass is about 40% to about 80% by weight of the bone graft composition.
12 . The bone graft composition of claim 11 , wherein the collagen carrier is porous.
13 . The bone graft composition of claim 11 , wherein the bioactive glass has a smooth surface.
14 . The bone graft composition of claim 11 , wherein the bioactive glass is about 80% by weight of the bone graft composition.
15 . The bone graft composition of claim 11 , wherein the bioactive glass is about 60% by weight of the bone graft composition.
16 . The bone graft composition of claim 11 , wherein the bioactive glass is 45S5 glass.
17 . The bone graft composition of claim 11 , wherein the collagen carrier includes type I collagen.
18 . The bone graft composition of claim 11 , wherein the collagen carrier and the bioactive glass collectively comprise 100% by weight of the bone graft composition.
19 . A bone graft composition, comprising:
a collagen carrier comprising about 10% to about 20% by weight of the bone graft composition;
a plurality of bioactive glass particles within the range of about 53 μm to about 425 μm in size and dispersed throughout the collagen carrier, at least 85% of the plurality of bioactive glass particles being within the range of 212 μm to 425 μm in size, the plurality of bioactive glass particles comprising about 25% to about 80% by weight of the bone graft composition, the plurality of bioactive glass particles each having a smooth surface.
20 . The bone graft composition of claim 19 , wherein the collagen includes type I collagen.