Methods and apparatus for retina blood vessel assessment with OCT angiography

1. A method, comprising performing, by a computer system with one or more processors and memory, operations comprising:

obtaining 3D Optical Coherence Tomography (OCT) data and 3D Optical Coherence Tomography Angiography (OCTA) data;

performing segmentation for at least one boundary on the OCT data;

processing the OCTA data with respect to the at least one segmented boundary from the OCT data to create an image representation by assigning an intensity value to each pixel of the image representation;

assigning a binary value to each pixel of the image representation to form a binarized representation, the binary value indicating whether the pixel corresponds to a vessel;

skeletonizing the binarized representation to form a skeletonized vessel map in which vessels are single-pixel wide;

assigning a vessel density value to each pixel of the skeletonized vessel map to form a vessel density map, the vessel density value corresponding to a mean value of the binary values in a region around each pixel of the optimized skeletonized vessel map; and

displaying the vessel density map.

2. The method of claim 1 , wherein obtaining the 3D OCTA data includes generating the 3D OCTA data from the 3D OCT data provided by an OCT imager.

3. The method of claim 1 , wherein performing segmentation includes segmenting of at least one layer to form an OCTA image.

4. The method of claim 3 , wherein the at least one layer is chosen from a set consisting of an internal limiting membrane (ILM), an inner plexiform layer (IPL), and a retinal pigment epitherial (RPE).

5. The method of claim 3 , further including computing a high flow area from the OCTA image.

6. The method of claim 3 , further including computing a low flow area from the OCTA image.

7. The method of claim 3 , further including computation of a foveal avascular zone from the OCTA image.

8. The method of claim 3 , further including computation of an enface vessel density from the OCTA image.

9. The method of claim 8 , further including calculating an enface vessel density map from the vessel density.

10. The method of claim 1 , wherein processing the OCTA data comprises

optimizing the skeletonized vessel map.

11. The method of claim 1 , further including

comparing the vessel density map with a normative database to form a vessel density significance map; and

displaying the vessel density significance map.

12. The method of claim 11 , wherein the normative database is stratified according to ethnicity, age, or gender.

13. The method of claim 1 , wherein processing the OCTA data includes

computing a fractional deviation from the vessel density map and a normative database;

computing a pattern deviation map;

analyzing the pattern deviation map to find fractional deviations; and

determining a loss.

14. The method of claim 13 , wherein determining a loss includes computation of a global loss volume.

15. The method of claim 13 , wherein determining a loss includes computation of a focal loss volume.

16. An image processing system comprising a computer system with one or more processors and memory, the computer system being configured to:

obtain 3D Optical Coherence Tomography (OCT) data and 3D Optical Coherence Tomography Angiography (OCTA) data;

perform segmentation for at least one boundary on the OCT data;

process the OCTA data with respect to the at least one segmented boundary from the OCT data to create an image representation by assigning an intensity value to each pixel of the image representation;

assign a binary value to each pixel of the image representation to form a binarized representation, the binary value indicating whether the intensity value of the pixel exceeds a predetermined threshold;

skeletonize the binarized representation to form a skeletonized vessel map in which vessels are single-pixel wide;

assign a vessel density value to each pixel of the skeletonized vessel map to form a vessel density map, the vessel density value corresponding to a mean value of the binary values in a region around each pixel of the optimized skeletonized vessel map; and

display the vessel density map.

17. The image processing system of claim 16 , wherein processing the OCTA data comprises

optimizing the skeletonized vessel map.

18. The image processing system of claim 16 , wherein the computer system is further configured to:

compare the vessel density map with a normative database to form a vessel density significance map; and

display the vessel density significance map.

19. The image processing system of claim 18 , wherein the normative database is stratified according to ethnicity, age, or gender.