IP Library Granted Patent US 10,321,958
Granted Patent B2
US 10,321,958 · App. 14/986,272 · Granted Jun 18, 2019

Method and system for image processing to determine patient-specific blood flow characteristics

Inventor: Charles A. Taylor (Menlo Park, CA)
Assignee: HeartFlow, Inc.
A61B34/10A61B5/004A61B5/0035A61B5/0044A61B5/02A61B5/021A61B5/024A61B5/026A61B5/02007A61B5/029A61B5/02028A61B5/0263A61B5/055A61B5/1075A61B5/1118A61B5/22A61B5/4848A61B5/6852A61B5/7246A61B5/7275A61B5/7278A61B5/745A61B6/03A61B6/032A61B6/481A61B6/503A61B6/504A61B6/507A61B6/5205A61B6/5217A61B6/5229A61B8/02A61B8/04A61B8/06A61B8/065A61B8/481A61B8/5223A61B8/5261A61B34/25A61M5/007G01R33/5601G01R33/5635G01R33/56366G06F17/10G06F17/5009G06F17/5018G06F19/00G06F19/12G06F19/26G06F19/321G06F19/324G06G7/60G06K9/00147G06K9/46G06K9/4604G06K9/52G06K9/6215G06K9/6267G06K9/6298G06T7/0012G06T7/0014G06T7/11G06T7/12G06T7/13G06T7/149G06T7/20G06T7/60G06T7/62G06T7/70G06T7/73G06T7/74G06T11/00G06T11/001G06T11/008G06T11/20G06T11/60G06T15/10G06T17/00G06T17/005G06T17/20G16H10/40G16H10/60G16H30/20G16H30/40G16H50/30G16H50/50G16H50/70A61B2034/104A61B2034/105A61B2034/107A61B2034/108A61B2090/374A61B2090/3762A61B2090/3764A61B2576/00A61B2576/023G06K2009/4666G06T2200/04G06T2207/10012G06T2207/10072G06T2207/10081G06T2207/10088G06T2207/10104G06T2207/10108G06T2207/20036G06T2207/20124G06T2207/30048G06T2207/30104G06T2210/41G06T2211/404Y02A90/22Y02A90/26
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Quick Facts
Patent No.
US 10,321,958
App. No.
14/986,272
Granted
Jun 18, 2019
Kind
B2
Abstract

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model.

Claims (50)

1. A system for image processing to determine cardiovascular information of a patient, the system comprising:

at least one computer system configured to:

receive non-invasively generated patient-specific data regarding a geometry of the patient's heart;

create a three-dimensional model of blood flow representing at least a portion of a vessel of the patient's heart using the non-invasively generated patient-specific data, wherein the three-dimensional model includes one or more boundary conditions of the vessel;

determine, non-invasively, a plurality of values of a blood flow characteristic within the vessel based on a simulation of blood flow in the three-dimensional model using the one or more boundary conditions of the vessel, the blood flow characteristic comprising a fractional flow reserve;

generate (1) an electronic visual representation of the vessel, (2) one or more indicators of the value of the blood flow characteristic, from the non-invasively determined plurality of values, on a corresponding portion of the vessel, and (3) a treatment option for treating the vessel, wherein the treatment option is automatically generated based on a comparison of one or more indicators on the corresponding portion of the vessel to a predetermined threshold; and

upon receiving an input from a user corresponding to a location along the vessel, update the electronic visual representation to display an indicator of the value of the blood flow characteristic corresponding to the location along the vessel.

2. The system of claim 1 , wherein the vessel is electronically displayed as being colored based upon a value of the blood flow characteristic at one or more locations along the vessel.

3. The system of claim 1 , wherein the computer system is further configured to:

upon determining that the value of the blood flow characteristic exceeds a predetermined threshold, display the value of the blood flow characteristic on a corresponding portion of the vessel.

4. The system of claim 1 , wherein the one or more indicators of the value of the blood flow characteristic are displayed in response to determining that the vessel of the patient's heart is associated with a value of the blood flow characteristic that exceeds a predetermined threshold.

5. The system of claim 1 , wherein the computer system is further configured to:

determine a plurality of values of the blood flow characteristic within an artery of the patient's heart; and

display a most functionally significant value of the blood flow characteristic from the plurality of blood flow characteristic values.

6. The system of claim 1 , wherein the computer system is further configured to:

determine the percentage of the myocardium placed at risk based upon the value of the blood flow characteristic; and

display the percentage of the myocardium placed at risk.

7. The system of claim 1 , wherein the computer system is further configured to:

determine a second value of the blood flow characteristic within the patient's heart based on the three-dimensional model; and

upon determining that the second value of the blood flow characteristic poses a greater risk to patient health, display the second value more prominently than the value of the blood flow characteristic.

8. The method of claim 1 , wherein a treatment option includes an option for no treatment or treatment based on exercise or medication.

9. A computer-implemented method for image processing to determine cardiovascular information of a patient, comprising:

receiving non-invasively generated patient-specific data regarding a geometry of the patient's heart;

creating a three-dimensional model of blood flow representing at least a portion of a vessel of the patient's heart using the non-invasively generated patient-specific data, wherein the three-dimensional model includes one or more boundary conditions of the vessel;

determining, non-invasively, a plurality of values of a blood flow characteristic within the vessel based on a simulation of blood flow in the three-dimensional model using the one or more boundary conditions of the vessel, the blood flow characteristic comprising a fractional flow reserve;

generating (1) an electronic visual representation of the vessel, (2) one or more indicators of the value of the blood flow characteristic, from the non-invasively determined plurality of values, on a corresponding portion of the vessel, and (3) a treatment option for treating the vessel, wherein the treatment option is automatically generated based on a comparison of one or more indicators on the corresponding portion of the vessel to a predetermined threshold; and

upon receiving an input from a user corresponding to a location along the vessel, updating the electronic visual representation to display an indicator of the value of the blood flow characteristic corresponding to the location along the vessel.

10. The method of claim 9 , wherein the vessel is electronically displayed as being colored based upon a value of the blood flow characteristic at one or more locations along the vessel.

11. The method of claim 9 , further comprising:

upon determining that the value of the blood flow characteristic exceeds a predetermined threshold, displaying the value of the blood flow characteristic on a corresponding portion of the vessel.

12. The method of claim 9 , wherein the one or more indicators of the value of the blood flow characteristic are displayed in response to determining that the vessel of the patient's heart is associated with a value of the blood flow characteristic that exceeds a predetermined threshold.

13. The method of claim 9 , further comprising:

determining a plurality of values of the blood flow characteristic within an artery of the patient's heart; and

displaying a most functionally significant value of the blood flow characteristic from the plurality of blood flow characteristic values.

14. The method of claim 9 , further comprising:

determining the percentage of the myocardium placed at risk based upon the value of the blood flow characteristic; and

displaying the percentage of the myocardium placed at risk.

15. The method of claim 9 , further comprising:

determining a second value of the blood flow characteristic within the patient's heart based on the three-dimensional model; and

upon determining that the second value of the blood flow characteristic poses a greater risk to patient health, displaying the second value more prominently than the value of the blood flow characteristic.

16. A non-transitory computer-readable medium storing instructions that, when executed by a processor, cause the processor to perform a method for image processing to determine cardiovascular information of a patient, the method including:

receiving non-invasively generated patient-specific data regarding a geometry of the patient's heart;

creating a three-dimensional model of blood flow representing at least a portion of a vessel of the patient's heart using the non-invasively generated patient-specific data, wherein the three-dimensional model includes one or more boundary conditions of the vessel;

determining, non-invasively, a plurality of values of a blood flow characteristic within the vessel based on a simulation of blood flow in the three-dimensional model using the one or more boundary conditions of the vessel, the blood flow characteristic comprising a fractional flow reserve;

generating (1) an electronic visual representation of the vessel, (2) one or more indicators of the value of the blood flow characteristic, from the non-invasively determined plurality of values, on a corresponding portion of the vessel, and (3) a treatment option for treating the vessel, wherein the treatment option is automatically generated based on a comparison of one or more indicators on the corresponding portion of the vessel to a predetermined threshold; and

upon receiving an input from a user corresponding to a location along the vessel, updating the electronic visual representation to display an indicator of the value of the blood flow characteristic corresponding to the location along the vessel.

17. The non-transitory computer-readable medium of claim 16 , wherein the vessel is electronically displayed as being colored based upon a value of the blood flow characteristic at one or more locations along the vessel.

18. The non-transitory computer-readable medium of claim 16 , further comprising:

upon determining that the value of the blood flow characteristic exceeds a predetermined threshold, displaying the value of the blood flow characteristic on a corresponding portion of the vessel.

19. The non-transitory computer-readable medium of claim 16 , wherein the one or more indicators of the value of the blood flow characteristic are displayed in response to determining that the vessel of the patient's heart is associated with a value of the blood flow characteristic that exceeds a predetermined threshold.

Assignments (5)
RELEASE OF SECURITY INTEREST Recorded Sep 11, 2025
From: HAYFIN SERVICES LLP
To: HEARTFLOW, INC.
Reel/Frame 072876/0775 →
RELEASE OF SECURITY INTEREST Recorded Jun 21, 2024
From: HAYFIN SERVICES LLP
To: HEARTFLOW, INC.
Reel/Frame 067801/0032 →
SECURITY INTEREST Recorded Jun 18, 2024
From: HEARTFLOW, INC.
To: HAYFIN SERVICES LLP
Reel/Frame 067775/0966 →
SECURITY INTEREST Recorded Jan 20, 2021
From: HEARTFLOW, INC.
To: HAYFIN SERVICES LLP
Reel/Frame 055037/0890 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 8, 2016
From: TAYLOR, CHARLES A.
To: HEARTFLOW, INC.
Reel/Frame 037437/0786 →
Continuity (10)
Continuation 14276442 · May 13, 2014
Continuation 13658739 · Oct 23, 2012
Continuation 13014835 · Jan 27, 2011
Division 13013561 · Jan 25, 2011
Provisional Application 61401462 · Aug 12, 2010
Provisional Application 61401915 · Aug 20, 2010
Provisional Application 61402308 · Aug 26, 2010
Provisional Application 61402345 · Aug 27, 2010
Provisional Application 61404429 · Oct 1, 2010
Related Publication 20160113726A1 · Apr 28, 2016
Cited By (1)
US 12,670,998