Processes for the preparation of pesticidal compounds
View Patent ↗The present application provides processes for making pesticidal compounds and compounds useful both as pesticides and in the making of pesticidal compounds.
1. A process for the preparation of N-(3-chloro-1-(pyridin-3-yl)-1H-pyrazol-4-yl)acetamide (1c)
which comprises reacting N-(3-chloro-1H-pyrazol-4-yl)acetamide (1b)
with a suitable halopyridine in the presence of a copper salt, an amine, and a base.
2. The process of claim 1 , wherein the halopyridine is 3-bromopyridine or 3-iodopyridine.
3. The process of claim 2 , wherein the halopyridine is 3-bromopyridine.
4. The process of claim 2 , wherein the halopyridine is 3-iodopyridine.
5. The process of claim 1 , wherein the base is an inorganic base.
6. The process of claim 5 , wherein the inorganic base is K 3 PO 4 .
7. The process of claim 1 , wherein the anime N,N′-dimethylethane-1,2-diamine.
8. The process of claim 1 , wherein the copper salt is selected from the group consisting of copper(I) chloride (CuCl), copper(II) chloride (CuCl 2 ) and copper(I) iodide (CuI).
9. The process of claim 8 , wherein the copper salt is CuCl.
10. The process of claim 8 , wherein the copper salt is CuCl 2 .
11. The process of claim 8 , wherein the copper salt is CuI.
12. The process of claim 1 , wherein the step of reacting is carried out in the presence of a polar solvent.
13. The process of claim 12 , wherein the polar solvent is acetonitrile, dioxane or DMF.