Granted Patent
B2
US 9,695,185 · App. 14/989,600 · Granted Jul 4, 2017
Synthetic methods for spiro-oxindole compounds
Inventors:
Jean-Jacques Alexandre Cadieux (Burnaby, CA); Mikhail Chafeev (Khimki, RU); Sultan Chowdhury (Surrey, CA); Jianmin Fu (Coquitlam, CA); Qi Jia (Burnaby, CA); Stefanie Abel (Thalwil, CH); Emad El-Sayed (Zumikon, CH); Elke Huthmann (Buchs, CH); Thomas Isarno (Niffer, FR)
Assignee:
Xenon Pharmaceuticals Inc.
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Abstract
This invention is directed to methods of preparing certain spiro-oxindole derivatives, which are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.
Claims (4)
1. A compound selected from the following formulae:
or a pharmaceutically acceptable salt thereof;
or a pharmaceutically acceptable salt thereof; and
or a pharmaceutically acceptable salt thereof.
Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Feb 16, 2016
From: CADIEUX, JEAN-JACQUES; CHAFEEV, MIKHAIL; CHOWDHURY, SULTAN; FU, JIANMIN; JIA, QI
To: XENON PHARMACEUTICALS INC.
Reel/Frame 037743/0001 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Feb 16, 2016
From: ABEL, STEFANIE; EL-SAYED, EMAD; HUTHMANN, ELKE; ISARNO, THOMAS
To: CARBOGEN AMCIS AG
Reel/Frame 037743/0032 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Feb 16, 2016
From: CARBOGEN AMCIS AG
To: XENON PHARMACEUTICALS INC.
Reel/Frame 037743/0135 →
Continuity (5)
Provisional Application
61251335
· Oct 14, 2009