METHOD FOR INHIBITING PLATELET AGGREGATION
A method for inhibiting platelet aggregation in a patient in need thereof, comprising 1) administering to the patient a bolus injection of an active drug, in an amount of between about 25 μg/kg, and 2) administering to the patient, after the bolus injection, an intravenous infusion for a period of between about 12 hours and about 72 hours, of the active drug, in an amount of about 0.15 μg/kg/min, wherein the active drug is tirofiban or a salt thereof.
1 . A method for reducing the risk of thrombosis, thromboembolism or reocclusion in a patient after surgery on peripheral arteries, comprising administering to the patient a bolus injection of about 25 μg/kg of tirofiban or salt thereof to inhibit platelet aggregation.
2 . The method of claim wherein the patient underwent peripheral arterial intervention.
3 . The method of claim 1 wherein the platelet aggregation occurs in peripheral arteries.
4 . The method of claim 1 wherein the bolus injection is at least 20 μg/kg of tirofiban or salt thereof.
5 . The method of claim 1 , wherein the salt is tirofiban hydrochloride.
6 . The method of claim 1 , further comprising administering to the patient, after the bolus injection, an intravenous infusion for a period of between about 12 hours and about 72 hours, of tirofiban or salt thereof to inhibit platelet aggregation, in an amount of about 0.15 μg/kg/min.
7 . The method of claim 6 wherein the intravenous infusion is about 12 hours.
8 . A method of preventing platelet thrombosis, thromboembolism or reocclusion after surgery on peripheral arteries in a patient comprising administering to the patient a bolus injection of tirofiban or salt thereof, in amounts sufficient to inhibit platelet aggregation.
9 . The method of claim 8 wherein the patient underwent peripheral arterial intervention.
10 . The method of claim 8 wherein the platelet aggregation occurs in peripheral arteries.
11 . The method of claim 8 wherein the bolus injection is at least 20 μg/kg of tirofiban or salt thereof.
12 . The method of claim 8 , wherein the salt is tirofiban hydrochloride.
13 . The method of claim 8 , further comprising administering to the patient, after the bolus injection, an intravenous infusion for a period of between about 12 hours and about 72 hours, of tirofiban or salt thereof to inhibit platelet aggregation, in an amount of about 0.15 μg/kg/min.
14 . The method of claim 8 wherein the intravenous infusion is about 12 hours.
15 . A method of preventing myocardial infarction in a patient after surgery on peripheral arteries in a patient comprising administering to the patient a bolus injection of tirofiban or salt thereof.
16 . The method of claim 15 wherein the patient underwent peripheral arterial intervention.
17 . The method of claim 15 wherein the bolus injection is at least 20 μg/kg of tirofiban or salt thereof.
18 . The method of claim 15 , wherein the salt is tirofiban hydrochloride.
19 . The method of claim 15 , further comprising administering to the patient, after the bolus injection, an intravenous infusion for a period of between about 12 hours and about 72 hours, of tirofiban or salt thereof to inhibit platelet aggregation, in an amount of about 0.15 μg/kg/min.
20 . The method of claim 15 wherein the intravenous infusion is about 12 hours.