Radiopaque monomers, polymers, microspheres, and methods related thereto
View Patent ↗Radiopaque monomers, polymers, and microspheres are disclosed herein. Methods of using the radiopaque monomers, polymers, and microspheres are disclosed herein. Methods of manufacturing radiopaque monomers, polymers, and microspheres are disclosed herein.
1. A microsphere comprising a polymer, wherein the polymer comprises a polymerized monomer of Formula I:
wherein n is 0-12 and wherein R is either an oxygen-containing moiety or a nitrogen-containing moiety,
wherein the polymer further comprises at least one of a polymerized N-[Tris(hydroxymethyl)methyl] acrylamide, a polymerized diethyl aminoethyl acrylamide, or a polymerized triethyl aminoethyl acrylamide.
2. The microsphere of claim 1 , wherein the polymer comprises a polymerized N-[Tris(hydroxymethyl)methyl] acrylamide.
3. The microsphere of claim 1 , wherein the polymer comprises a polymerized monomer of Formula la or Formula Ib:
or a salt thereof.
4. The microsphere of claim 1 , wherein the microsphere has a diameter of about 10 microns to about 2000 microns.
5. The microsphere of claim 1 , wherein the microsphere swells upon exposure to physiologic conditions.
6. The microsphere of claim 1 , wherein the microsphere comprises a therapeutic agent.
7. A method of embolization, the method comprising injecting the microsphere of claim 1 into a blood vessel of a patient.
8. A method of tracking a microsphere in a patient, the method comprising:
introducing the microsphere of claim 1 into a patient; and
imaging at least a portion of the patient and determining a location of the microsphere.
9. The method of claim 8 , wherein a contrast agent is not present in the location of the microsphere at the time of imaging.
10. The method of claim 8 , further comprising detecting a location of the microsphere more than about 24 hours, more than about 48 hours, more than about a week, or more than about a month after introducing the microsphere.
11. The method of claim 8 , further comprising injecting a contrast agent prior to introducing the microsphere to determine an arterial structure of the patient and then after introducing the microsphere, detecting a location of the microsphere after the contrast agent has dissipated.
12. A method of treating a disease, disorder, or cosmetic need of a patient, the method comprising injecting the microsphere of claim 1 into a blood vessel or tissue of the patient.
13. A method of treating cancer, the method comprising injecting the microsphere of claim 1 into a blood vessel of a patient and tracking a location of the microsphere.
14. The microsphere of claim 1 , wherein the polymer further comprises at least one of a cross-linker, a gelatin, or a coloring agent.
15. The microsphere of claim 1 , wherein the polymer further comprises an additional radiopaque agent.
16. The microsphere of claim 1 , wherein the polymer further comprises a magnetic agent.
17. A microsphere comprising a polymer, wherein the polymer comprises a polymerized monomer of Formula I:
wherein n is 0-12 and wherein R is either an oxygen-containing moiety or a nitrogen-containing moiety,
wherein the polymer further comprises a polymerized N-[Tris(hydroxymethyl) methyl] acrylamide, and
wherein the microsphere is non-resorbable within a patient's body.
18. The microsphere of claim 17 , wherein the polymer comprises a polymerized monomer of Formula la or Formula Ib:
or a salt thereof.
19. The microsphere of claim 17 , wherein the microsphere swells upon exposure to physiologic conditions.
20. The microsphere of claim 17 , wherein the microsphere comprises a therapeutic agent.