Controlled Photomechanical and Photothermal Treatment of Mucosal Tissue
Systems and methods for treating mucosal tissue by concentrating a laser emission to at least one depth at a fluence sufficient to create an ablation volume in at least a portion of the mucosal tissue and controlling pulse width within the picosecond regime to provide a desired mechanical pressure in the form of shock waves and/or pressure waves.
1 . A method for tissue treatment, comprising:
providing a picosecond laser having a wavelength between about 532-1064 nanometers (nm), a pulsewidth of about 100 to 750 picoseconds (ps), and a fluence of about 20-80 joules per square centimeter (J/cm̂2);
delivering light from the picosecond laser to a target region comprising mucosal tissue; and
causing laser induced optical breakdown in the target region by exceeding the electron avalanche breakdown threshold of the mucosal tissue, the laser induced optical breakdown stimulating autonomous tissue regeneration in the target region.
2 . The method of claim 1 comprising:
coupling the picosecond laser to a microlens array, the microlens array creating a plurality of micro focal zones within the target region; and
causing laser induced optical breakdown in a plurality of the micro focal zones.
3 . The method of claim 1 , further comprising a controller for controlling the selected pulse width to provide shock wave pressure wave emission intensity to the tissue adjacent the target region at a shorter pulse width and a lesser shock wave pressure wave emission intensity to the tissue adjacent the target region at a longer pulse width.
4 . The method of claim 1 , wherein the target region is located at least 25 micrometers (μm) below a surface of the mucosal tissue surface.
5 . The method of claim 1 , wherein the delivering light comprises concentrating the light through at least one foci.
6 . The method of claim 5 , wherein concentrating the light comprises focusing the laser emission to a depth of desired treatment.
7 . A method of increasing the elastin content of mucosal tissue comprising:
using a picosecond laser having a wavelength between about 532-1064 nanometers (nm), a pulse width of about 100 to 750 picoseconds (ps), and a fluence of about 20-80 joules per square centimeter (J/cm̂2);
delivering light from the picosecond laser to a target mucosal tissue;
generating, from the delivered light, ionization induced heating of the target mucosal tissue such that heat induced bubble formation generates a subsurface pressure wave; and
initiating one or more elastin changes in the target mucosal tissue in response to the propagation of the pressure wave.
8 . The method of claim 7 , further comprising self focusing the light and generating one or more channels in the mucosal tissue.
9 . The method of claim 8 , comprising forming a substantially spherical micro injury.
10 . The method of claim 8 , comprising creating a self-focusing micro filament by selecting a fluence that matches beam divergence for the target mucosal tissue.
11 . The method of claim 10 , comprising forming a filamentous micro injury.
12 . The method of claim 11 , wherein a filamentous micro injury forms at least 25 micrometers (μm) below a surface of the target mucosal tissue.
13 . The method of claim 12 , wherein the filamentous injury extends up to about 1 centimeter (cm) below the surface of the target mucosal tissue.
14 . The method of claim 8 , comprising administering a vasodilator to the target mucosal tissue prior to delivering light.
15 . The method of claim 14 , wherein the picosecond laser has a wavelength of about 755 nanometers (nm).
16 . The method of claim 7 wherein the one or more elastin changes comprise elastin remodeling.
17 . The method of claim 7 wherein the one or more elastin changes comprise increasing a concentration of elastin.
18 . The method of claim 7 wherein the one or more elastin changes comprise depositing elastin in the mucosal tissue.