Compositions and methods for enhancing brain function

1. A method to enhance cognitive function in humans, comprising:

administering to a human a nutritional supplement composition comprising,

huperzine A;

vinpocetine;

acetyl-L-carnitine; and

rhodiola ; and

formulating the nutritional supplemental composition for oral administration, wherein the huperzine A, vinpocetine, rhodiola , and acetyl-L-carnitine are in a ratio a:b:c:d respectively such that a as the huperzine A is between about 0.8 and 1.2, b as the vinpocetine is between about 80 and 120, c as the rhodiola is between about 1,600 and 2,400 and d as the acetyl-L-carnitine is between about 8,000 and 12,000.

2. The method according to claim 1 , further comprising a vitamin B complex (e) in a ratio a:b:c:d:e with the huperzine A, vinpocetine, rhodiola , and acetyl-L-carnitine such that e as the Vitamin B complex is between about 700 and 1,200.

3. The method according to claim 2 , wherein the vitamin B complex comprises vitamins B3, B5 and B6.

4. The method according to claim 1 , further comprising a green tea and guarana extract (f) in a ratio a:b:c:d:f with the huperzine A, vinpocetine, rhodiola , and acetyl-L-carnitine such that f as the green tea and guarana extract is between about 1,600 and 2,400.

5. The method according to claim 1 , wherein the rhodiola comprises about 2 to 4 percent rosavins and 0.5 to 1.5 percent salidrosides.

6. The method according to claim 1 , wherein huperzine A, acetyl-L-carnitine, vinpocetine and rhodiola together account for at least 80 wt % of a dosage unit of the composition.

7. The method according to claim 1 , wherein the huperzine A, vinpoceine, rhodiola and acetyl-L-carnitine are in a weight ratio to each other such that the huperzine A is between about 0.9 and 1.1, the vinpocetine is between about 90 and 110, the rhodiola is between about 1,800 and 2,200, and the acetyl-L-carnitine is between about 9,000 and 10,000.

8. The method according to claim 1 , comprising delivering 1,250 mg to 1,500 mg of acetyl-L-carnitine per daily dose.

9. The method according to claim 1 , comprising delivering 10 mg to 30 mg of vinpocetine per daily dose.

10. The method according to claim 1 , comprising delivering 250 mg to 350 mg of rhodiola per daily dose.

11. The method according to claim 1 , comprising delivering 50 mcg to 200 mcg of huperzine A per daily dose.

12. The method according to claim 1 , wherein the composition is formulated as a tablet having an enteric coating.

13. The method according to claim 1 , further comprising an inactive ingredient selected from the group consisting of a carrier, a binder, an excipient, a dye, and combinations thereof.

14. A method to enhance cognitive function in humans, comprising:

administering to a human a nutritional supplement composition comprising:

huperzine A;

vinpocetine;

acetyl-L-carnitine;

rhodiola;

a vitamin B complex comprising vitamins B3, B5 and B6; and

a green tea and guarana extract; wherein the huperzine A, vinpocetine, rhodiola , acetyl-L-carnitine, each of the Vitamins B3, B5 and B6, and the green tea and guarana extract are in a ratio of a:b:c:d:e:f respectively such that a as the huperzine A is between about 0.8 and 1.2, b as the vinpocetine is between about 80 and 120, c as the rhodiola is between about 1600 and 2400, d as the acetyl-L-carnitine is between about 8,000 and 12,000, e as each of the Vitamins B3, B5 and B6 is between about 250 to 400 and f as the green tea and guarana extract is between about 1,600 and 2,400;

formulating the composition for oral administration;

delivering from about 50 mcg to 200 mcg of huperzine A per daily dose;

delivering from about 10 mg to 30 mg of vinpocetine per daily dose;

delivering from about 250 mg to 350 mg of rhodiola per daily dose;

delivering about 1,250 mg to 1,500 mg of acetyl-L-carnitine per daily dose;

delivering from about 40 mg to 60 mg of each of the Vitamins B3, B5 and B6 per daily dose; and

delivering from about 250 mg to 350 mg of the green tea and guarana extract per daily dose, wherein the huperzine A, acetyl-L-carnitine, vinpocetine and rhodiola together account for at least 80 wt % of a dosage unit of the composition.

15. The method according to claim 14 , wherein the huperzine A, vinpoceine, rhodiola and acetyl-L-carnitine are in a weight ratio to each other such that the huperzine A is between about 0.9 and about 1.1, the vinpocetine is between about 90 and about 110, the rhodiola is between about 1,800 and 2,200, and the acetyl-L-carnitine is between about 9,000 and 10,000.

16. The method according to claim 14 , wherein the rhodiola comprises about 2 to 4 percent rosavins and 0.5 to 1.5 percent salidrosides.

17. The method according to claim 14 , wherein the Vitamin B3 comprises Niacin and Niacinamide.

18. The method according to claim 14 , wherein the Vitamin B5 comprises pantothenic acid as D-calcium pantothenate.

19. A method to enhance cognitive function in humans, comprising:

administering to a human a nutritional supplement composition comprising,

huperzine A;

vinpocetine;

acetyl-L-carnitine;

rhodiola ; and

a vitamin B complex that includes at least one of vitamins B3, B5 and B6;

formulating the nutritional supplemental composition for oral administration, wherein the huperzine A, vinpocetine, rhodiola , acetyl-L-carnitine, and vitamin B complex that includes at least one of vitamins B3, B5 and B6 are in a ratio a:b:c:d:e respectively such that a as the huperzine A is between about 0.8 and 1.2, b as the vinpocetine is between about 80 and 120, c as the rhodiola is between about 1,600 and 2,400, d as the acetyl-L-carnitine is between about 8,000 and 12,000, and e as the vitamin B complex that includes at least one of vitamins B3, B5 and B6 is between about 700 and 1,200.