IP Library › Patent Application 14999245
Patent Application
App. No. 14/999,245

Bone tissue engineering by ex vivo stem cells ongrowth into three-dimensional trabecular metal

Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US None
App. No.
14/999,245
Abstract

Adult autologous stem cells cultured on a porous, three-dimensional tissue scaffold-implant for bone regeneration by the use of a hyaluronan and/or dexamethasone to accelerate bone healing alone or in combination with recombinant growth factors or transfected osteogenic genes. The scaffold-implant may be machined into a custom-shaped three-dimensional cell culture system for support of cell growth, reservoir for peptides, recombinant growth factors, cytokines and antineoplastic drugs in the presence of a hyaluronan and/or dexamethasone alone or in combination with growth factors or transfected osteogenic genes, to be assembled ex vivo in a tissue incubator for implantation into bone tissue.

Claims (4)

1 . A three-dimensional tissue scaffold-implant for supporting tissue on-growth, the scaffold-implant comprising:

a lattice having a matrix of interconnected pores which form surfaces in three dimensions;

an inert, bio-compatible material covering the surfaces; and

at least one of a hyaluronan, dexamethasone, protein, peptide, transcript factor, cytokine, therapeutic agent, chitosan, polymer, osteogenic gene and growth factor, covering the'material.