SYSTEMS, COMPOSITIONS, AND METHODS OF LIPID PANEL TEST CONTROLS UTILIZING PARTICLES THAT MIMIC HEMATOCRIT
A calibration sample includes serum/plasma having a known level of a first analyte and a plurality of particles that mimic the characteristics of red blood cells.
1 . A calibration sample comprising:
serum/plasma having a known level of a first analyte; and
a plurality of particles that mimic the characteristics of red blood cells.
2 . The calibration sample of claim 1 , wherein the plurality of particles are of red florescent particles.
3 . The calibration sample of claim 2 , wherein the red florescent particles are polystyrene.
4 . The calibration sample of claim 2 , wherein the red florescent particles are selected from the group consisting of other polymeric material and silica based particles.
5 . The calibration sample of claim 3 , wherein an amount of red florescent particles added to the serum/plasma is 20% of the plasma volume.
6 . The calibration sample of claim 3 , wherein the amount of red florescent particles added to the serum/plasma is between 5% and 50% of the plasma volume.
7 . The calibration sample of claim 1 , wherein the plurality of particles are non-dyed particles.
8 . The calibration sample of claim 7 , wherein an amount of non-dyed particles added to the serum/plasma is 20% of the plasma volume.
9 . The calibration sample of claim 7 , wherein the amount of non-dyed particles added to the serum/plasma is between 5% and 50% of the plasma volume.
10 . The calibration sample of claim 1 , wherein the first analyte is one of a plurality of analytes, the plurality of analytes consisting of HDL, LDL, triglycerides, creatinine, ketone, total cholesterol, and glucose.
11 . A method of improving a calibration sample for use with a vertical flow test strip, comprising:
providing serum/plasma having a known level of a first analyte; and
adding a plurality of particles that mimic the characteristics of red blood cells.
12 . The method of claim 11 , wherein the plurality of particles are of red florescent particles.
13 . The method of claim 12 , wherein an amount of red florescent particles added to the serum/plasma is 20% of the plasma volume.
14 . The method of claim 12 , wherein the amount of red florescent particles added to the serum/plasma is between 5% and 50% of the plasma volume.
15 . A method of calibrating a meter, the meter utilizing a vertical flow test strip, the method comprising:
providing serum/plasma having a known level of a first analyte; and
adjusting the viscosity of the serum/plasma by adding a plurality of particles that mimic the characteristics of red blood cells.
16 . A method of adjusting calibration results of a vertical flow test strip having a limited dynamic range, calibrated with a calibration sample, the calibration sample including serum/plasma having a known level of a first analyte, the method comprising:
adding a plurality of particles that mimic the characteristics of red blood cells.
17 . The method of claim 16 , wherein the plurality of particles are of red florescent particles.
18 . The method of claim 17 , wherein an amount of red florescent particles added to the serum/plasma is 20% of the plasma volume.
19 . The method of claim 17 , wherein the amount of red florescent particles added to the serum/plasma is between 5% and 50% of the plasma volume.
20 . The method of claim 16 , wherein the first analyte is HDL.
21 . The method of claim 20 , wherein the calibration results are adjusted down to be within the upper limit of the limited dynamic range.