Systems and methods for compensating long term sensitivity drift of electrochemical gas sensors exposed to nitric oxide

1. A gas delivery system, comprising:

a gas delivery subsystem configured to deliver therapeutic gas comprising nitric oxide from a therapeutic gas source to a breathing circuit of a patient;

a system controller including a processor in communication with a memory;

the memory having stored thereon a calibration schedule for performing a plurality of baseline calibrations and a calibration line correlating of expected sensor output values from at least one sensor to therapeutic gas concentration;

at least one sensor configured to measure a concentration of the therapeutic gas;

wherein the system controller is configured to adjust the measurements of the at least one sensor according to the correlation of sensor outputs to therapeutic gas concentration;

wherein the system controller is configured to cause the at least one sensor to be calibrated according to the calibration schedule that dictates when the plurality of baseline calibrations should occur, wherein the calibration schedule is changed upon a change in a set dosage, wherein the calibration schedule is based on the set dosage;

wherein during the plurality of baseline calibrations the at least one sensor measures an actual output value indicative of a zero concentration of the therapeutic gas while only being exposed to a gas having a zero concentration of the therapeutic gas; and

wherein the system controller is configured to adjust the correlation of expected sensor output values to therapeutic gas concentration according to the difference in the actual output value and the expected output value.

2. The gas delivery system of claim 1 , wherein the system controller is configured to postpone a scheduled calibration of the at least one sensor when there is an alarm condition.

3. The gas delivery system of claim 1 , wherein the system controller is configured to postpone a scheduled calibration of the at least one sensor when an alarm condition occurs within a predetermined interval before the scheduled calibration.

4. The gas delivery system of claim 1 , further comprising:

the breathing circuit configured for delivery of the therapeutic gas to the patient.

5. The gas delivery system of claim 4 , wherein the at least one sensor measures the concentration of nitric oxide in the breathing circuit.

6. The gas delivery system of claim 1 , further comprising:

a display configured to present the concentration of nitric oxide measured by the at least one sensor.

7. The gas delivery system of claim 6 , wherein the display is configured to present that there is an alarm condition.

8. A gas delivery system comprising:

a system controller including a memory having stored thereon a calibration schedule for performing a plurality of baseline calibrations and a calibration line correlating expected sensor output values from a nitric oxide sensor to nitric oxide gas concentration;

a breathing circuit configured to deliver nitric oxide to a patient; and

the nitric oxide sensor configured to continuously measure a concentration of nitric oxide in the breathing circuit and communicate with the system controller;

wherein the system controller is configured to deliver nitric oxide to the patient according to an input set dosage;

wherein the system controller is configured to identify according to the calibration schedule in the memory when the plurality of baseline calibrations is intended to be performed, accounting for the input set dosage;

wherein the system controller is further configured to schedule a time for executing the plurality of baseline calibrations of the nitric oxide sensor according to the calibration schedule;

wherein the system controller changes the calibration schedule upon a change in the input set dosage;

wherein the calibration schedule is based on the input set dosage;

wherein the system controller is configured to adjust the measurements of the nitric oxide sensor according to the calibration line;

wherein during the plurality of baseline calibrations the nitric oxide sensor measures an output value indicative of a zero concentration of nitric oxide while only being exposed to a gas having a zero concentration of nitric oxide; and

wherein the system controller is configured to offset the calibration line by the absolute value of the output value indicative of a zero concentration of nitric oxide.

9. The gas delivery system of claim 8 , wherein the system controller is configured to postpone the calibration of the nitric oxide sensor when an alarm is active or has been active within a predetermined timeframe from the time the calibration is to be executed.

10. The gas delivery system of claim 8 , wherein the calibration schedule comprises a set of values representing intended intervals between interruptions of the continuous measuring of the nitric oxide concentration.

11. The gas delivery system of claim 10 , wherein the intended intervals vary with respect to the absolute change in set dose.

12. The gas delivery system of claim 8 , wherein the system controller is configured to adjust the calibration line by offsetting the slope of the previous calibration line according to the output value indicative of a zero concentration of nitric oxide.

13. The gas delivery system of claim 8 , wherein the system controller is configured to utilize the type of the nitric oxide sensor when identifying the calibration schedule.

14. The gas delivery system of claim 13 , wherein the nitric oxide sensor is one of a three terminal electrochemical nitric oxide gas sensor and a four terminal electrochemical nitric oxide gas sensor.

15. The gas delivery system of claim 8 , wherein the gas having a zero concentration of nitric oxide is ambient air.

16. A gas delivery system comprising:

a system controller including a memory having stored thereon a calibration schedule for performing a plurality of baseline calibrations and a calibration line correlating expected sensor output values from at least one four terminal electrochemical nitric oxide gas sensor to nitric oxide gas concentration;

a breathing circuit configured to deliver nitric oxide gas to a patient; and

at least one four terminal electrochemical nitric oxide gas sensor configured to continuously measure a concentration of nitric oxide in the breathing circuit and communicate with the system controller;

wherein the system controller is configured to deliver the nitric oxide gas to the patient according to an input set dosage;

wherein the system controller is configured to identify according to the calibration schedule in the memory when the plurality of baseline calibrations is intended to be performed accounting for the input set dosage, wherein the plurality of the baseline calibration occurs sooner based upon a larger change in set dosage;

wherein the system controller is further configured to schedule a time for executing the plurality of the baseline calibration of the at least one four terminal electrochemical nitric oxide gas sensor according to the calibration schedule;

wherein the system controller changes the calibration schedule upon a change in the set dosage;

wherein the calibration schedule is based on the set dosage;

wherein the system controller is configured to adjust the measurements of the at least one four terminal electrochemical nitric oxide gas sensor according to the calibration line;

wherein during the plurality of baseline calibrations the sensor measures an output value indicative of a zero concentration of nitric oxide while only being exposed to a gas having a zero concentration of nitric oxide; and

wherein the system controller is configured to offset the calibration line by the absolute value of the output value indicative of a zero concentration of nitric oxide.

17. The gas delivery system of claim 16 , wherein the plurality of baseline calibrations further occurs according to an absolute change in the set dosage.