Bioactive grafts and composites

1. A method of making an osteoinductive implant, comprising steps in the following order:

1) harvesting bone material from a donor; wherein the harvested bone material is cancellous bone, or a combination of cancellous and cortical bone, the harvested bone material retaining cellular materials during the harvesting, the cellular materials comprising bone marrow;

2) exposing the bone marrow to a lysing agent, the lysing agent configured to release bone morphogenetic proteins from the bone marrow of the harvested bone material, wherein the lysing agent is acetic acid having a concentration of at least 1% and a molarity range of about 0.2M to 17M;

3) allowing the bone morphogenetic proteins released from the bone marrow of the harvested bone material to bind to the cancellous bone material;

4) demineralizing the cancellous bone material with the bone morphogenetic proteins bound thereto, with hydrochloric acid;

5) rinsing the harvested bone material with a rinsing agent.

2. The method of claim 1 , further comprising a step of forming the harvested bone material into a shape for implantation into a body.

3. The method of claim 1 , wherein the rinsing agent is at least one of: water, a saline, a peroxide, an alcohol, a crystalloid, an antibiotic solution, a preserving fluid, and a storage agent.

4. The method of claim 1 , further comprising a step of dehydrating the harvested bone material.

5. The method of claim 4 , wherein a step of dehydration further comprises at least one of: evaporation, vacuum drying, and lyophilization.