IP Library Granted Patent US 9,971,952
Granted Patent B2
US 9,971,952 · App. 15/019,417 · Granted May 15, 2018

System and method for three-dimensional nerve segmentation using curved multiplanar reformatting magnetic resonance imaging

Inventors: Saso Koceski (Skopje, MK); Filip Shteriev (Skopje, MK); Domenico Ciambrone (L'Aquila, IT); Lionel Lenkinski (Toronto, CA); Robert Lenkinski (Dallas, TX)
Assignee: 3D Imaging Partners
G06K9/4604G06K9/0014G06T7/12G06T15/08G06T19/00G06T2207/10088G06T2207/30101G06T2207/30172G06T2215/06G06T2219/008
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Quick Facts
Patent No.
US 9,971,952
App. No.
15/019,417
Granted
May 15, 2018
Kind
B2
Abstract

Systems and methods for segmenting a nerve in a three-dimensional image volume obtained with a magnetic resonance imaging (“MRI”) system are provided. A three-dimensional image volume that depicts a nerve and surrounding anatomical structures is provided and from that image volume the nerve is segmented. In general, a curved multiplanar reformatting (“CMPR”) process is utilized to mark, segment, and then display the nerve in three dimensions.

Claims (16)

1. A method for segmenting a nerve in a three-dimensional image volume obtained with a magnetic resonance imaging (MRI) system, the steps of the method comprising:

(a) providing a three-dimensional image volume that depicts a nerve and surrounding anatomical structures in a series of contiguous image slices obtained with an MRI system;

(b) selecting a cross-sectional image from the image volume;

(c) generating a plurality of planes that intersect at a common point in the selected cross-sectional image and are orthogonal to the selected cross-sectional image;

(d) generating a planar reformatted image for each of the plurality of planes;

(e) estimating nerve contours in each of the planar reformatted images;

(f) receiving user feedback to adjust the estimated nerve contours;

(g) generating a surface estimate based on the adjusted nerve contours; and

(h) generating a volume that defines the nerve segmented from the surrounding anatomical structures based on the generated surface estimate.

2. The method as recited in claim 1 , wherein step (f) includes receiving user feedback to adjust a position of a point in the estimated nerve contour and recalculating the estimate of the nerve contour based on the received user feedback.

3. The method as recited in claim 1 , wherein step (f) includes adding at least one additional point to the estimated nerve contour based on the received user feedback.

4. The method as recited in claim 1 , wherein step (c) includes selecting a number of desired planes.

5. The method as recited in claim 1 , wherein step (g) includes generating an in-slice spline for each image slice based on an intersection of the estimated nerve contours with a given image slice.

6. The method as recited in claim 5 , wherein step (g) includes generating the surface estimate as a surface rendering based on the in-slice splines for each image slice.

7. The method as recited in claim 6 , wherein each surface rendering is generated based on intersection points defined by intersections of vectors extending from a center of the in-slice spline for a given image slice and the in-slice spline for that given image slice.

8. The method as recited in claim 7 , wherein each surface rendering is generated as a mesh triangulation based on the intersection points.

Assignments (3)
RELEASE OF SECURITY INTEREST Recorded Mar 19, 2021
From: INNOVATUS LIFE SCIENCES LENDING FUND I, LP, AS COLLATERAL AGENT
To: BIODESIX, INC.
Reel/Frame 055657/0911 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 24, 2018
From: KOCESKI, SASO; SHTERIEV, FILIP; CIAMBRONE, DOMENICO; LENKINSKI, LIONEL; LENKINSKI, ROBERT
To: 3D IMAGING PARTNERS
Reel/Frame 045624/0857 →
SECURITY INTEREST Recorded Feb 23, 2018
From: BIODESIX, INC.
To: INNOVATUS LIFE SCIENCES LENDING FUND I, LP, AS COLLATERAL AGENT
Reel/Frame 045022/0976 →
Continuity (2)
Provisional Application 62114253 · Feb 10, 2015
Related Publication 20160232664A1 · Aug 11, 2016