IP Library Granted Patent US 10,995,118
Granted Patent B2
US 10,995,118 · App. 15/022,749 · Granted May 4, 2021

Amyloid-beta-binding peptides and the use thereof for the treatment and diagnosis of alzheimer's disease

Inventor: Dieter Willbold (Juelich, DE)
Assignee: Forschungszentrum Juelich GmbH
C07K7/08A61K38/10A61K38/12A61K38/16G01N33/6896A61K38/00G01N2333/4709G01N2800/2821
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Quick Facts
Patent No.
US 10,995,118
App. No.
15/022,749
Granted
May 4, 2021
Kind
B2
Abstract

Amyloid beta-binding peptides and the use thereof for the treatment and the diagnosis of Alzheimer's disease.

Claims (4)

1. A peptide comprising an amino acid sequence which binds to amyloid beta species and in which the negative charge of its free C-terminus carboxyl group was removed by modification such that no charge or a positive charge is present at said free C-terminus,

wherein the amino acid sequence is SEQ ID NO: 12, and

wherein the free C-terminus carboxyl group is replaced with an acid amide group (CONH2 group), a COH group, a CONH-alkyl group or a CONH-alkyl amine group, and

wherein the peptide's binding affinity to the amyloid beta species is increased as compared to an analogous peptide without the C-terminus modification.

Assignments (3)
CORRECTIVE ASSIGNMENT TO CORRECT THE THE APPLICATION NUMBERS PREVIOUSLY RECORDED AT REEL: 058475 FRAME: 0768. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT. Recorded Feb 11, 2022
From: FORSCHUNGSZENTRUM JÜLICH GMBH
To: PRIAVOID GMBH
Reel/Frame 059034/0548 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 24, 2021
From: FORSCHUNGSZENTRUM JÜLICH GMBH, 52425 JÜLICH, GERMANY (DE)
To: PRIAVOID GMBH
Reel/Frame 058475/0768 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 11, 2016
From: WILLBOLD, DIETER
To: FORSCHUNGSZENTRUM JUELICH GMBH
Reel/Frame 038400/0323 →