IP Library › Granted Patent US 10,227,323

Granted Patent B2

US 10,227,323 · App. 15/023,337 · Granted Mar 12, 2019

Glucosylceramide synthase inhibitors for the treatment of diseases

Inventors: Bing Wang (San Jose, CA); Daniel Chu (Santa Clara, CA); Alexander James Bridges (Saline, MI)

C07D319/18 C07B59/002 C07D205/04 C07D209/04 C07D211/46 C07D213/46 C07D213/56 C07D213/61 C07D213/64 C07D215/06 C07D231/56 C07D235/06 C07D235/08 C07D265/30 C07D277/22 C07D277/30 C07D277/62 C07D295/12 C07D295/13 C07D305/08 C07D307/79 C07D307/81 C07D309/10 C07D309/12 C07D311/12 C07D311/58 C07D333/16 C07D333/24 C07D333/60 C07D333/62 C07D405/06 C07D405/12 C07D405/14 C07D407/12 C07D409/12 C07D413/12 C07D417/12 C07D471/04 C07D471/08 C07D487/08 C07D491/056 C07B2200/05 C07B2200/07

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Patent No.: US 10,227,323
App. No.: 15/023,337
Granted: Mar 12, 2019
Kind: B2

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Abstract

Described herein are compounds of Formula I, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or conditions associated with the enzyme glucosylceramide synthase (GCS).

Claims (531)

1. A compound of Formula I:

wherein

R 1 is —C(O)C(R 6 )(R 6a )R 1a or —C(O)C(R 6 )(R 6a )—X 1 —R 1a ;

X 1 is alkylene, alkenylene, or cycloalkylene;

R 1a is alkyl, heterocycloalkyl, aryl or heteroaryl each of which is optionally substituted with 1, 2, or 3 R 7 groups; wherein when R 1a is phenyl, R 1a is substituted with 1, 2, or 3 R 7 groups;

R 2 and R 3 together with the nitrogen to which they are attached form a 3-10 membered heterocycloalkyl ring, optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 R 8 ;

R 4 is phenyl substituted with a halo and a cycloalkyloxy group;

R 5 is —OH, and R 5a is hydrogen;

R 6 and R 6a are halo; R 6 and R 6a are deuterium; or R 6 and R 6a together with the carbon to which they are attached form C(═NOH) or C(O);

each R 7 , when present, is independently nitro, cyano, amino, alkylamino, dialkylamino, halo, haloalkyl, alkyl, alkenyl, alkynyl, hydroxy, alkoxy, haloalkoxy, alkoxycarbonyl, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, cycloalkyl, heterocycloalkyl, phenyl, phenylalkyl, phenyloxy, heteroaryl, heteroarylalkyl, or heteroaryloxy; where the phenyl and the heteroaryl, either alone or as part of another group, are independently optionally substituted with 1, 2 or 3 R 7a ;

each R 7a , when present, is independently selected from cyano, halo, alkyl, alkenyl, haloalkyl, hydroxyalkyl, and cycloalkyl;

each R 8 , when present, is independently deuterium, amino, alkylamino, dialkylamino, alkyl, hydroxy, alkoxy, halo, haloalkyl, or cycloalkyl; or two R 8 together with the carbon to which they are attached form C(O); and

R 12 is hydrogen or C 1-5 alkyl;

optionally a tautomer, a single stereoisomer or mixture of stereoisomers thereof and additionally optionally a pharmaceutically acceptable salt thereof.

2. The compound of claim 1 , wherein the compound of Formula I is according to Formula I(b):

optionally as a tautomer, a single stereoisomer or mixture of stereoisomers thereof and additionally optionally as a pharmaceutically acceptable salt thereof.

3. The compound of claim 1 , wherein the compound of Formula I is according to Formula I(c):

optionally as a tautomer, a single stereoisomer or mixture of stereoisomers thereof and additionally optionally as a pharmaceutically acceptable salt thereof.

4. The compound of claim 1 , wherein R 2 and R 3 together with the nitrogen to which they are attached form a 4-5 membered monocyclic heterocycloalkyl ring or a 7-8 membered bicyclic heterocycloalkyl; each of which is optionally substituted with 1 or 2 R 8 ; optionally as a tautomer, a single stereoisomer or mixture of stereoisomers thereof and additionally optionally as a pharmaceutically acceptable salt thereof.

5. The compound of claim 4 , wherein R 2 and R 3 together with the nitrogen to which they are attached form a 4-5 membered monocyclic heterocycloalkyl ring, optionally substituted with 1 or 2 R 8 ; optionally as a tautomer, a single stereoisomer or mixture of stereoisomers thereof and additionally optionally as a pharmaceutically acceptable salt thereof.

6. The compound of claim 1 , wherein R 1 is —C(O)C(R 6 )(R 6a )R 1a ; optionally as a tautomer, a single stereoisomer or mixture of stereoisomers thereof and additionally optionally as a pharmaceutically acceptable salt thereof.

7. The compound of claim 1 , wherein R 1 is —C(O)C(R 6 )(R 6a )—X 1 —R 1a ; optionally as a tautomer, a single stereoisomer or mixture of stereoisomers thereof and additionally optionally as a pharmaceutically acceptable salt thereof.

8. The compound of claim 7 , wherein X 1 is C 1-3 alkylene; optionally as a tautomer, a single stereoisomer or mixture of stereoisomers thereof and additionally optionally as a pharmaceutically acceptable salt thereof.

9. The compound of claim 1 , wherein R 1a is aryl optionally substituted with 1, 2, or 3 R 7 groups; wherein when R 1a is phenyl, R 1a is substituted with 1, 2, or 3 R 7 groups; optionally as a tautomer, a single stereoisomer or mixture of stereoisomers thereof and additionally optionally as a pharmaceutically acceptable salt thereof.

10. The compound of claim 9 , wherein R 1a is phenyl substituted with 1 R 7 group, wherein each R 7 is independently phenyl, heterocycloalkyl, or heteroaryl; where the phenyl and the heteroaryl are independently optionally substituted with 1 or 2 R 7a ; optionally as a tautomer, a single stereoisomer or mixture of stereoisomers thereof and additionally optionally as a pharmaceutically acceptable salt thereof.

11. The compound of claim 1 , wherein R 1a is heteroaryl optionally substituted with 1, 2, or 3 R 7 groups; optionally as a tautomer, a single stereoisomer or mixture of stereoisomers thereof and additionally optionally as a pharmaceutically acceptable salt thereof.

12. The compound of claim 11 , wherein R 1a is heteroaryl optionally substituted with 1 or 2 R 7 groups, wherein each R 7 , when present, is independently halo, alkyl, cycloalkyl, heterocycloalkyl, phenyl, phenylalkyl, or heteroaryl; where the phenyl and the heteroaryl, either alone or as part of another group, are independently optionally substituted with 1 R 7a ; optionally as a tautomer, a single stereoisomer or mixture of stereoisomers thereof and additionally optionally as a pharmaceutically acceptable salt thereof.

13. The compound of claim 1 , wherein R 6 and R 6a together with the carbon to which they are attached form C(O) or C(═NOH); optionally as a tautomer, a single stereoisomer or mixture of stereoisomers thereof and additionally optionally as a pharmaceutically acceptable salt thereof.

14. The compound of claim 13 , wherein R 6 and R 6a together with the carbon to which they are attached form C(O); optionally as a tautomer, a single stereoisomer or mixture of stereoisomers thereof and additionally optionally as a pharmaceutically acceptable salt thereof.

15. The compound of claim 1 , wherein R 6 and R 6a are halo; optionally as a tautomer, a single stereoisomer or mixture of stereoisomers thereof and additionally optionally as a pharmaceutically acceptable salt thereof.

16. The compound of claim 15 , wherein R 6 and R 6a are fluoro; optionally as a tautomer, a single stereoisomer or mixture of stereoisomers thereof and additionally optionally as a pharmaceutically acceptable salt thereof.

17. The compound of claim 1 wherein:

R 1 is —C(O)C(R 6 )(R 6a )R 1a or —C(O)C(R 6 )(R 6a )—X 1 —R 1a ;

X 1 is alkylene, alkenylene, or cycloalkylene;

R 1a is alkyl, heterocycloalkyl, aryl or heteroaryl each of which is optionally substituted with 1, 2, or 3 R 7 groups; wherein when R 1a is phenyl, R 1a is substituted with 1, 2, or 3 R 7 groups;

R 2 and R 3 together with the nitrogen to which they are attached form a 4-5 membered monocyclic heterocycloalkyl ring or a 7-8 membered bicyclic heterocycloalkyl; each of which is optionally substituted with 1 or 2 R 8 ;

R 4 is phenyl substituted with a halo and a cycloalkyloxy group;

R 5 is —OH, and R 5a is hydrogen;

R 6 and R 6a are halo; or R 6 and R 6a together with the carbon to which they are attached form C(═NOH) or C(O);

each R 7 , when present, is independently nitro, cyano, halo, haloalkyl, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, phenyl, phenylalkyl, phenyloxy, heteroaryl, heteroarylalkyl, or heteroaryloxy; where the phenyl and the heteroaryl, either alone or as part of another group, are independently optionally substituted with 1, 2 or 3 R 7a ;

each R 7a , when present, is independently selected from cyano, halo, alkyl, alkenyl, haloalkyl, hydroxyalkyl, and cycloalkyl;

each R 8 , when present, is independently amino, alkylamino, dialkylamino, alkyl, halo, or cycloalkyl; or two R 8 together with the carbon to which they are attached form C(O); and

R 12 is hydrogen or CH 3 ;

optionally a tautomer, a single stereoisomer or mixture of stereoisomers thereof and additionally optionally a pharmaceutically acceptable salt thereof.

18. The compound of claim 1 wherein:

R 1 is —C(O)C(R 6 )(R 6a )R 1a or —C(O)C(R 6 )(R 6a )—X 1 —R 1a ;

X 1 is alkylene;

R 1a is heterocycloalkyl, aryl or heteroaryl each of which is optionally substituted with 1, 2, or 3 R 7 groups; wherein when R 1a is phenyl, R 1a is substituted with 1, 2, or 3 R 7 groups;

R 4 is phenyl substituted with a halo and a cycloalkyloxy group;

R 5 is —OH, and R 5a is hydrogen;

R 6 and R 6a are halo; or R 6 and R 6a together with the carbon to which they are attached form or C(O);

each R 7a , when present, is independently selected from cyano, halo, alkyl, alkenyl, haloalkyl, hydroxyalkyl, and cycloalkyl;

each R 8 , when present, is independently amino, alkylamino, dialkylamino, alkyl, or halo; and

R 12 is hydrogen or CH 3 ;

optionally a tautomer, a single stereoisomer or mixture of stereoisomers thereof and additionally optionally a pharmaceutically acceptable salt thereof.

19. A compound selected from the group consisting of:

N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-oxo-2-(4,5,6,7-tetrahydro-2H-isoindol-1-yl)acetamide;

N-((1R,2R)-3-(azetidin-1-yl)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxypropan-2-yl)-2-(5-chlorobenzofuran-2-yl)-2-oxoacetamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(5-chlorobenzofuran-2-yl)-2-oxoacetamide;

2-(5-chlorobenzofuran-2-yl)-2,2-difluoro-N-((1S,2R)-1-hydroxy-1-(6-isopropoxypyridin-3-yl)-3-(pyrrolidin-1-yl)propan-2-yl)acetamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2,2-difluoro-4-(6-fluoronaphthalen-2-yl)butanamide;

N-((1R,2R)-3-(azetidin-1-yl)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxypropan-2-yl)-2-(5-chlorobenzofuran-2-yl)-2,2-difluoroacetamide;

N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2,2-difluoro-4-(6-fluoronaphthalen-2-yl)butanamide;

2-(5-chlorobenzofuran-2-yl)-2,2-difluoro-N-((1R,2R)-1-hydroxy-3-(pyrrolidin-1-yl)-1-(6-(2,2,2-trifluoroethoxy)pyridin-3-yl)propan-2-yl)acetamide;

N-((1R,2R)-3-(azetidin-1-yl)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxypropan-2-yl)-2,2-difluoro-4-(6-fluoronaphthalen-2-yl)butanamide;

2,2-difluoro-N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-4-(6-fluoronaphthalen-2-yl)butanamide;

2,2-difluoro-4-(6-fluoronaphthalen-2-yl)-N-((1R,2R)-1-hydroxy-3-(pyrrolidin-1-yl)-1-(6-(2,2,2-trifluoroethoxy)pyridin-3-yl)propan-2-yl)butanamide;

N-((1R,2R)-3-(azetidin-1-yl)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxypropan-2-yl)-2-(5-chlorobenzofuran-2-yl)-2-oxoacetamide;

N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-4-(6-fluoronaphthalen-2-yl)-2-oxobutanamide;

2-(5-chloro-2,3-dihydro-1H-inden-2-yl)-2,2-difluoro-N-((1R,2R)-1-hydroxy-3-(pyrrolidin-1-yl)-1-(6-(2,2,2-trifluoroethoxy)pyridin-3-yl)propan-2-yl)acetamide;

N-((1R,2R)-3-(azetidin-1-yl)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxypropan-2-yl)-2-(5-chloro-2,3-dihydro-1H-inden-2-yl)-2,2-difluoroacetamide;

2-(5-chloro-2,3-dihydro-1H-inden-2-yl)-2,2-difluoro-N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)acetamide;

N-((1R,2R)-1-(3-chloro-4-isopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(5-chlorobenzofuran-2-yl)-2,2-difluoroacetamide;

2-(5-chlorobenzofuran-2-yl)-N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-oxoacetamide;

N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(3-methylazetidin-1-yl)propan-2-yl)-2,2-difluoro-4-(6-fluoronaphthalen-2-yl)butanamide;

2,2-difluoro-4-(6-fluoronaphthalen-2-yl)-N-((1R,2R)-1-hydroxy-1-(6-isopropoxypyridin-3-yl)-3-(pyrrolidin-1-yl)propan-2-yl)butanamide;

N-((1R,2R)-3-(azetidin-1-yl)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxypropan-2-yl)-2-(5-chlorobenzofuran-2-yl)-2-(hydroxyimino)acetamide;

2-(5-chlorobenzofuran-2-yl)-N-((1R,2R)-1-(6-cyclopropoxypyridin-3-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2,2-difluoroacetamide;

2-(5-chlorobenzofuran-2-yl)-N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(3-methylazetidin-1-yl)propan-2-yl)-2-oxoacetamide;

N-((1R,2R)-1-(6-cyclopropoxypyridin-3-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2,2-difluoro-4-(6-fluoronaphthalen-2-yl)butanamide;

(E)-2-(5-chlorobenzofuran-2-yl)-N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(3-methylazetidin-1-yl)propan-2-yl)-2-(hydroxyimino)acetamide;

2-(5-chlorobenzofuran-2-yl)-2,2-difluoro-N-((1 S,2R)-1-hydroxy-1-(2-isopropoxypyridin-4-yl)-3-(pyrrolidin-1-yl)propan-2-yl)acetamide;

(E)-2-(5-chlorobenzofuran-2-yl)-N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(hydroxyimino)acetamide;

N-((1R,2R)-1-(3-chloro-4-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(5-chlorobenzofuran-2-yl)-2,2-difluoroacetamide;

(E)-N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-4-(6-fluoronaphthalen-2-yl)-2-(hydroxyimino)butanamide;

2,2-difluoro-N-((1R,2R)-1-hydroxy-1-(6-isopropoxypyridin-3-yl)-3-(pyrrolidin-1-yl)propan-2-yl)-4-(naphthalen-2-yl)butanamide;

2,2-difluoro-N-((1R,2R)-1-hydroxy-3-(pyrrolidin-1-yl)-1-(6-(2,2,2-trifluoroethoxy)pyridin-3-yl)propan-2-yl)-4-(naphthalen-2-yl)butanamide;

2,2-difluoro-N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-4-(naphthalen-2-yl)butanamide;

N-((1R,2R)-1-(3-chloro-4-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2,2-difluoro-4-(naphthalen-2-yl)butanamide;

N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-4-(6-fluoronaphthalen-2-yl)-2-oxobutanamide;

(E)-N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-4-(6-fluoronaphthalen-2-yl)-2-(hydroxyimino)butanamide;

N-((1 S,2R)-3-(azetidin-1-yl)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxypropan-2-yl)-2,2-difluoro-4-(naphthalen-2-yl)butanamide;

2,2-difluoro-4-(6-fluoronaphthalen-2-yl)-N-((1R,2R)-1-hydroxy-1-(2-isopropoxypyridin-4-yl)-3-(pyrrolidin-1-yl)propan-2-yl)butanamide;

(E)-N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-4-(6-fluoronaphthalen-2-yl)-2-(hydroxyimino)butanamide;

2-(5-chloro-2,3-dihydro-1H-inden-2-yl)-N-((1R,2R)-1-(3-chloro-4-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2,2-difluoroacetamide;

N-((1 S,2R)-1-(2,2-dimethylchroman-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2,2-difluoro-4-(naphthalen-2-yl)butanamide;

(E)-N-((1R,2R)-3-(azetidin-1-yl)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxypropan-2-yl)-4-(6-fluoronaphthalen-2-yl)-2-(hydroxyimino)butanamide;

2-(5-chlorobenzofuran-2-yl)-N-((1R,2R)-1-(2,2-dimethylchroman-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2,2-difluoroacetamide;

N-((1R,2R)-1-(6-cyclopropoxypyridin-3-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2,2-difluoro-4-(naphthalen-2-yl)butanamide;

N-((1R,2R)-1-(3-chloro-4-((1-methylpiperidin-4-yl)oxy)phenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2,2-difluoro-4-(naphthalen-2-yl)butanamide;

N-((1R,2R)-3-(azetidin-1-yl)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxypropan-2-yl)-2-(5-chlorobenzofuran-2-yl)-2-oxoacetamide;

N-((1R,2R)-1-(3-chloro-4-((1-methylpiperidin-4-yl)oxy)phenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(5-chlorobenzofuran-2-yl)-2,2-difluoroacetamide;

N-((1S,2R)-1-(3-chloro-4-morpholinophenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2,2-difluoro-4-(naphthalen-2-yl)butanamide;

N-((1R,2R)-1-(4-cyclopropoxy-3-fluorophenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2,2-difluoro-4-(naphthalen-2-yl)butanamide;

2-(5-chlorobenzofuran-2-yl)-N-((1R,2R)-1-(4-cyclopropoxy-3-fluorophenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2,2-difluoroacetamide;

N-((1R,2R)-1-(3-chloro-4-morpholinophenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(5-chlorobenzofuran-2-yl)-2,2-difluoroacetamide;

N-((1R,2R)-1-(4-(2-(azetidin-1-yl)ethoxy)-3-chlorophenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(5-chlorobenzofuran-2-yl)-2,2-difluoroacetamide;

N-((1R,2R)-1-(3-chloro-4-(oxetan-3-yloxy)phenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2,2-difluoro-4-(naphthalen-2-yl)butanamide;

N-((1R,2R)-1-(3-chloro-4-(oxetan-3-yloxy)phenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(5-chlorobenzofuran-2-yl)-2,2-difluoroacetamide;

N-((1R,2R)-1-(4-(2-(azetidin-1-yl)ethoxy)-3-chlorophenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2,2-difluoro-4-(naphthalen-2-yl)butanamide;

2-(6-chloronaphthalen-2-yl)-N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2,2-difluoroacetamide;

N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(4′-fluoro-[1,1′-biphenyl]-4-yl)-2-oxoacetamide;

N-((1R,2R)-3-(azetidin-1-yl)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxypropan-2-yl)-2,2-difluoro-4-(6-fluoronaphthalen-2-yl)butanamide;

2-(6-chloronaphthalen-2-yl)-2,2-difluoro-N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)acetamide;

(E)-N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(5-chlorobenzofuran-2-yl)-2-(hydroxyimino)acetamide;

(E)-N-((1R,2R)-3-(azetidin-1-yl)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxypropan-2-yl)-4-(6-fluoronaphthalen-2-yl)-2-(hydroxyimino)butanamide;

(E)-N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(4′-fluoro-[1,1′-biphenyl]-4-yl)-2-(hydroxyimino)acetamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(6-chloronaphthalen-2-yl)-2,2-difluoroacetamide;

2,2-difluoro-N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(4′-fluoro-[1,1′-biphenyl]-4-yl)acetamide;

(E)-N-((1R,2R)-3-(azetidin-1-yl)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxypropan-2-yl)-2-(hydroxyimino)-4-(naphthalen-2-yl)butanamide;

(E)-N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(hydroxyimino)-4-(naphthalen-2-yl)butanamide;

N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-4-(naphthalen-2-yl)-2-oxobutanamide;

N-((1R,2R)-3-(azetidin-1-yl)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxypropan-2-yl)-2,2-difluoro-4-(naphthalen-2-yl)butanamide;

N-((1R,2R)-3-(azetidin-1-yl)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxypropan-2-yl)-4-(naphthalen-2-yl)-2-oxobutanamide;

N-((1R,2R)-1-(3-chloro-4-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(6-chloronaphthalen-2-yl)-2,2-difluoroacetamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-4-(naphthalen-2-yl)-2-oxobutanamide;

(E)-N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(hydroxyimino)-4-(naphthalen-2-yl)butanamide;

N-((1R,2R)-1-(3-chloro-4-cylopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(4′-fluoro-[1,1′-biphenyl]-4-yl)-2-oxoacetamide;

N-((1R,2R)-3-(azetidin-1-yl)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxypropan-2-yl)-2-(4′-fluoro-[1,1′-biphenyl]-4-yl)-2-oxoacetamide;

2-(6-chloronaphthalen-2-yl)-N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-oxoacetamide;

N-((1R,2R)-1-(3-chloro-4-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(4′-fluoro-[1,1′-biphenyl]-4-yl)-2-oxoacetamide;

(E)-N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(4′-fluoro-[1,1′-biphenyl]-4-yl)-2-(hydroxyimino)acetamide;

N-((1R,2R)-3-(azetidin-1-yl)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxypropan-2-yl)-4-(6-fluoronaphthalen-2-yl)-2-oxobutanamide;

(E)-N-((1R,2R)-3-(azetidin-1-yl)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxypropan-2-yl)-2-(4′-fluoro-[1,1′-biphenyl]-4-yl)-2-(hydroxyimino)acetamide;

2-(7-chloronaphthalen-2-yl)-N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-oxoacetamide;

N-((1R,2R)-3-(azetidin-1-yl)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxypropan-2-yl)-2,2-difluoro-2-(4′-fluoro-[1,1′-biphenyl]-4-yl)acetamide;

(E)-2-(6-chloronaphthalen-2-yl)-N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(hydroxyimino)acetamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2,2-difluoro-2-(4′-fluoro-[1,1′-biphenyl]-4-yl)acetamide;

N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2,2-difluoro-2-(4′-fluoro-[1,1′-biphenyl]-4-yl)acetamide;

N-((1R,2R)-3-(azetidin-1-yl)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxypropan-2-yl)-2,2-difluoro-2-(4′-fluoro-[1,1′-biphenyl]-4-yl)acetamide;

N-((1R,2R)-3-(azetidin-1-yl)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxypropan-2-yl)-2,2-difluoro-2-(4′-fluoro-[1,1′-biphenyl]-4-yl)acetamide;

N-((1R,2R)-1-(3-chloro-4-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2,2-difluoro-2-(4′-fluoro-[1,1′-biphenyl]-4-yl)acetamide;

(E)-N-((1R,2R)-3-(azetidin-1-yl)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxypropan-2-yl)-2-(hydroxyimino)-4-(naphthalen-2-yl)butanamide;

N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2,2-difluoro-4-(5,6,7,8-tetrahydronaphthalen-2-yl)butanamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2,2-difluoro-4-(5,6,7,8-tetrahydronaphthalen-2-yl)butanamide;

2,2-difluoro-N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-4-(5,6,7,8-tetrahydronaphthalen-2-yl)butanamide;

N-((1 S,2R)-1-(3-chloro-4-(2-hydroxy-2-methylpropoxy)phenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(5-chlorobenzofuran-2-yl)-2,2-difluoroacetamide;

(E)-N-((1R,2R)-3-(azetidin-1-yl)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxypropan-2-yl)-2-(5-chlorobenzofuran-2-yl)-2-(hydroxyimino)acetamide;

N-((1R,2R)-3-(azetidin-1-yl)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxypropan-2-yl)-4-(naphthalen-2-yl)-2-oxobutanamide;

N-((1R,2R)-3-(azetidin-1-yl)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxypropan-2-yl)-2,2-difluoro-4-(naphthalen-2-yl)butanamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(6-chloronaphthalen-2-yl)-2-oxoacetamide;

(E)-N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(6-chloronaphthalen-2-yl)-2-(hydroxyimino)acetamide;

N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(5-(4-fluorophenyl)thiophen-2-yl)-2-oxoacetamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(4-(5-fluoropyridin-2-yl)phenyl)-2-oxoacetamide;

N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(4-(5-fluoropyridin-2-yl)phenyl)-2-oxoacetamide;

(E)-N-((1R,2R)-1-(3-chloro-4-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(4′-fluoro-[1,1′-biphenyl]-4-yl)-2-(hydroxyimino)acetamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2,2-difluoro-2-(4-(5-fluoropyridin-2-yl)phenyl)acetamide;

N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2,2-difluoro-2-(4-(5-fluoropyridin-2-yl)phenyl)acetamide;

N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2,2-difluoro-2-(5-(4-fluorophenyl)thiophen-2-yl)acetamide;

(Z)—N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(5-(4-fluorophenyl)thiophen-2-yl)-2-(hydroxyimino)acetamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2,2-difluoro-2-(4-(pyridin-2-yl)phenyl)acetamide;

2,2-difluoro-N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(4-(5-fluoropyridin-2-yl)phenyl)acetamide;

(E)-N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(4-(5-fluoropyridin-2-yl)phenyl)-2-(hydroxyimino)acetamide;

2-(5-chlorobenzofuran-2-yl)-N-((1R,2R)-1-(2,3-dihydro-[1,4]dioxino[2,3-b]pyridin-7-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2,2-difluoroacetamide;

N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2,2-difluoro-2-(4-(pyridin-2-yl)phenyl)acetamide;

2,2-difluoro-N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(4-(pyridin-2-yl)phenyl)acetamide;

N-((1R,2R)-3-(azetidin-1l-yl)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxypropan-2-yl)-2-(6-chloronaphthalen-2-yl)-2-oxoacetamide;

N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(4-(5-fluoropyridin-2-yl)phenyl)-2-oxoacetamide;

(E)-N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(4-(5-fluoropyridin-2-yl)phenyl)-2-(hydroxyimino)acetamide;

(E)-N-((1R,2R)-3-(azetidin-1-yl)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxypropan-2-yl)-2-(6-chloronaphthalen-2-yl)-2-(hydroxyimino)acetamide;

2-(5-chloro-2,3-dihydro-1H-inden-2-yl)-N-((1R,2R)-1-(3-chloro-4-(2-hydroxy-2-methylpropoxy)phenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2,2-difluoroacetamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2,2-difluoro-4-(1-methyl-1,2,3,4-tetrahydroquinolin-6-yl)butanamide;

N-((1R,2R)-1-(3-chloro-4-(2-hydroxy-2-methylpropoxy)phenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(4′-fluoro-[1,1′-biphenyl]-4-yl)-2-oxoacetamide;

N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-oxo-2-(4-(pyridin-2-yl)phenyl)acetamide;

2,2-difluoro-N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(imidazo[1,2-a]pyridin-2-yl)acetamide;

N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(3-(4-fluorophenoxy)phenyl)-2-oxoacetamide;

N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2,2-difluoro-4-(1-methyl-1,2,3,4-tetrahydroquinolin-6-yl)butanamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2,2-difluoro-2-(imidazo[1,2-a]pyridin-2-yl)acetamide;

N-((2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-oxo-2-(4-(piperidin-1-yl)phenyl)acetamide;

N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2,2-difluoro-2-(3-(4-fluorophenoxy)phenyl)acetamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2,2-difluoro-2-(4-(1-methyl-1H-indazol-5-yl)phenyl)acetamide;

N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(3-(4-fluorophenoxy)phenyl)-2-oxoacetamide;

N-((1R,2R)-1-(4-cyclopropoxy-3-fluorophenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2,2-difluoro-2-(4′-fluoro-[1,1′-biphenyl]-4-yl)acetamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphecycxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(4-(1-methyl-1H-indazol-5-yl)phenyl)-2-oxoacetamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2,2-difluoro-2-(3-(4-fluorophenoxy)phenyl)acetamide;

N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(4-(1-methyl-1H-indazol-5-yl)phenyl)-2-oxoacetamide;

N-((1R,2R)-1-(4-cyclopropoxy-3-fluorophenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(4′-fluoro-[1,1′-biphenyl]-4-yl)-2-oxoacetamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(naphthalen-2-yl)-2-oxoacetamide;

2,2-difluoro-N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(3-(4-fluorophenoxy)phenyl)acetamide;

N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2,2-difluoro-2-(2-(4-fluorophenyl)thiazol-4-yl)acetamide;

N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2,2-difluoro-2-(4-(1-methyl-1H-indazol-5-yl)phenyl)acetamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2,2-difluoro-2-(2-(4-fluorophenyl)thiazol-4-yl)acetamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-oxo-2-(4-(pyridin-2-yl)phenyl)acetamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(2-(4-fluorophenyl)thiazol-5-yl)-2-oxoacetamide;

N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(1-methyl-1H-indazol-5-yl)-2-oxoacetamide;

N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(1-methyl-1H-indazol-5-yl)-2-oxoacetamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2,2-difluoro-2-(5-(4-fluorophenyl)thiophen-2-yl)acetamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(5-(4-fluorophenyl)thiophen-2-yl)-2-oxoacetamide;

N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(4-(1-methyl-1H-indazol-5-yl)phenyl)-2-oxoacetamide;

2,2-difluoro-N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(2-(4-fluorophenyl)thiazol-4-yl)acetamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2,2-difluoro-2-(2-(4-fluorophenyl)thiazol-5-yl)acetamide;

N-((1R,2R)-3-(azetidin-1-yl)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxypropan-2-yl)-2-(4-(1-methyl-1H-indazol-5-yl)phenyl)-2-oxoacetamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(1-methyl-1H-indazol-5-yl)-2-oxoacetamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(2-chlorobenzo[b]thiophen-5-yl)-2-oxoacetamide;

N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(2-(4-fluorophenyl)thiazol-4-yl)-2-oxoacetamide;

N-((1R,2R)-3-(azetidin-1-yl)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxypropan-2-yl)-2-oxo-2-(4-(piperidin-1-yl)phenyl)acetamide;

N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-oxo-2-(4-(pyridin-2-yl)phenyl)acetamide;

N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(2-(4-fluorophenyl)thiazol-4-yl)-2-oxoacetamide;

N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(5-(4-fluorophenyl)thiophen-2-yl)-2-oxoacetamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-oxo-2-(4-(piperidin-1-yl)phenyl)acetamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2,2-difluoro-2-(4-(1-methyl-1H-indazol-6-yl)phenyl)acetamide;

2-(benzo[b]thiophen-5-yl)-N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-oxoacetamide;

N-((1R,2R)-1-(8-chloro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(4′-fluoro-[1,1′-biphenyl]-4-yl)-2-oxoacetamide;

N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2,2-difluoro-2-(4-(1-methyl-1H-indazol-6-yl)phenyl)acetamide;

2,2-difluoro-N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(4-(1-methyl-1H-indazol-6-yl)phenyl)acetamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2,2-difluoro-2-(4-(2-methyl-2H-indazol-6-yl)phenyl)acetamide;

N-((2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-oxo-2-(3-(piperidin-1-yl)phenyl)acetamide;

2,2-difluoro-N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(5-(4-fluorophenyl)thiophen-2-yl)acetamide;

N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(4-(2-methyl-2H-indazol-5-yl)phenyl)-2-oxoacetamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(4-(4-fluorophenoxy)phenyl)-2-oxoacetamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(6-chlorobenzo[b]thiophen-2-yl)-2-oxoacetamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(4-(1-methyl-1H-indazol-6-yl)phenyl)-2-oxoacetamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(1-methyl-1H-indazol-6-yl)-2-oxoacetamide;

N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(1-methyl-1H-indazol-6-yl)-2-oxoacetamide;

N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(4-(1-methyl-1H-indazol-6-yl)phenyl)-2-oxoacetamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2,2-difluoro-2-(6-(4-fluorophenyl)pyridin-3-yl)acetamide;

N-((1R,2R)-3-(azetidin-1-yl)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxypropan-2-yl)-2-(3-(4-fluorophenoxy)phenyl)-2-oxoacetamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(3-(4-fluorophenoxy)phenyl)-2-oxoacetamide;

N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(4′-fluoro-[1,1′-biphenyl]-3-yl)-2-oxoacetamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(4′-fluoro-[1,1′-biphenyl]-3-yl)-2-oxoacetamide;

N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(4-(4-fluorophenyl)piperazin-1-yl)-2-oxoacetamide;

N-((1R,2R)-3-(azetidin-1-yl)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxypropan-2-yl)-2-(4′-fluoro-[1,1′-biphenyl]-4-yl)-2-oxoacetamide;

N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(4-(4-fluorophenyl)piperazin-1-yl)-2-oxoacetamide;

2-(4′-(tert-butyl)-[1,1′-biphenyl]-4-yl)-N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-oxoacetamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(4-(1-isopropyl-1H-indazol-6-yl)phenyl)-2-oxoacetamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(4-(2-isopropyl-2H-indazol-6-yl)phenyl)-2-oxoacetamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(4-(1-isopropyl-1H-indazol-5-yl)phenyl)-2-oxoacetamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(4-(2-isopropyl-2H-indazol-5-yl)phenyl)-2-oxoacetamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2,2-difluoro-2-(5-(4-fluorophenyl)pyridin-2-yl)acetamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(3-(1-methyl-1H-indazol-6-yl)phenyl)-2-oxoacetamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(4-(4-fluorophenyl)piperazin-1-yl)-2-oxoacetamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(4-(2-chlorobenzo[b]thiophen-5-yl)phenyl)-2-oxoacetamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(5-(4-fluorophenyl)pyridin-2-yl)-2-oxoacetamide;

N-((1R,2R)-1-(4-cyclopropoxy-3-(trifluoromethyl)phenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(4′-fluoro-[1,1′-biphenyl]-4-yl)-2-oxoacetamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(4-(1-isopropyl-1H-indol-5-yl)phenyl)-2-oxoacetamide;

2-(4′-chloro-[1,1′-biphenyl]-4-yl)-N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-oxoacetamide;

N-((1R,2R)-1-(5-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(4′-fluoro-[1,1′-biphenyl]-4-yl)-2-oxoacetamide;

N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(4-(1-isopropyl-1H-indol-5-yl)phenyl)-2-oxoacetamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(4′-chloro-[1,1′-biphenyl]-4-yl)-2-oxoacetamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(4-(1-isopropyl-1H-benzo[d]imidazol-5-yl)phenyl)-2-oxoacetamide;

2-(4′-chloro-[1,1′-biphenyl]-4-yl)-N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-oxoacetamide;

N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-oxo-2-(4-(pyrrolidin-1-yl)phenyl)acetamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-oxo-2-(4′-(trifluoromethyl)-[1,1′-biphenyl]-4-yl)acetamide;

2-(4-(1-cyclopropyl-1H-indazol-5-yl)phenyl)-N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-oxoacetamide;

N-((1R,2R)-1-(8-chloro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(4-(1-cyclopropyl-1H-indazol-5-yl)phenyl)-2-oxoacetamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(4-(1-cyclopropyl-1H-indazol-5-yl)phenyl)-2-oxoacetamide;

N-((1R,2R)-3-(azetidin-1-yl)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxypropan-2-yl)-2-(4-(1-cyclopropyl-1H-indazol-5-yl)phenyl)-2-oxoacetamide;

N-((1R,2R)-3-(azetidin-1-yl)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxypropan-2-yl)-2-(4-(1-methyl-1H-indazol-5-yl)phenyl)-2-oxoacetamide;

2-(4-(benzo[d]isoxazol-6-yl)phenyl)-N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-oxoacetamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(4-(1-cyclopropyl-1H-indazol-6-yl)phenyl)-2-oxoacetamide

2-(4-(1-cyclopropyl-1H-indazol-6-yl)phenyl)-N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-oxoacetamide;

N-((1R,2R)-3-(azetidin-1-yl)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxypropan-2-yl)-2-(4-(1-cyclopropyl-1H-indazol-6-yl)phenyl)-2-oxoacetamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(4-(2-cyclopropyl-2H-indazol-6-yl)phenyl)-2-oxoacetamide;

N-((1R,2R)-3-(azetidin-1-yl)-1-(8-chloro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxypropan-2-yl)-2-(4-(1-cyclopropyl-1H-indazol-5-yl)phenyl)-2-oxoacetamide;

2-(4′-fluoro-[1,1′-biphenyl]-4-yl)-N-((1R,2R)-1-hydroxy-3-(pyrrolidin-1-yl)-1-(8-(trifluoromethyl)-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)propan-2-yl)-2-oxoacetamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(6-(4-fluorophenyl)pyridin-3-yl)-2-oxoacetamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(1-(4-fluorobenzyl)-1H-indazol-5-yl)-2-oxoacetamide;

N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(1-(4-fluorobenzyl)-1H-indazol-5-yl)-2-oxoacetamide;

2-(4-(benzo[d]isoxazol-5-yl)phenyl)-N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-oxoacetamide;

N-((1R,2R)-1-(4-(tert-butoxy)-3-chorophenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(4′-fluoro-[1,1′-biphenyl]-4-yl)-2-oxoacetamide;

2-(6-chlorobenzo[b]thiophen-2-yl)-N-((1R,2R)-1-(4-cyclopropoxy-3-fluorophenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-oxoacetamide;

N-((1R,2R)-3-(azetidin-1-yl)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxypropan-2-yl)-2-(4′-(tert-butyl)-[1,1′-biphenyl]-4-yl)-2-oxoacetamide;

2-(4′-(tert-butyl)-[1,1′-biphenyl]-4-yl)-N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-oxoacetamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(4′-fluoro-2′-methyl-[1,1′-biphenyl]-4-yl)-2-oxoacetamide;

2-(4-(benzo[d]thiazol-5-yl)phenyl)-N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-oxoacetamide;

2-(4-(benzo[d]thiazol-6-yl)phenyl)-N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-oxoacetamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(4′-fluoro-2-methyl-[1,1′-biphenyl]-4-yl)-2-oxoacetamide;

N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(4′-fluoro-2-methyl-[1,1′-biphenyl]-4-yl)-2-oxoacetamide;

N-((1R,2R)-3-(azetidin-1-yl)-1-(8-chloro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxypropan-2-yl)-2-(4′-fluoro-[1,1′-biphenyl]-4-yl)-2-oxoacetamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(4′-cyano-[1,1′-biphenyl]-4-yl)-2-oxoacetamide;

2-(8-bromodibenzo[b,d]furan-2-yl)-N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-oxoacetamide;

N-[(1R,2R)-2-(3-chloro-4-cyclopropoxyphenyl)-2-hydroxy-1-(pyrrolidinylmethyl)ethyl]-2-[4-(4-fluorophenyl)phenyl]acetamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(2-(4-fluorobenzyl)-2H-indazol-5-yl)-2-oxoacetamide;

N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(2-(4-fluorobenzyl)-2H-indazol-5-yl)-2-oxoacetamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(1-isopropyl-1H-indazol-6-yl)-2-oxoacetamide;

N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(1-isopropyl-1H-indazol-6-yl)-2-oxoacetamide;

2-(6-chlorobenzo[b]thiophen-2-yl)-N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-oxoacetamide;

N-((1R,2R)-1-(3-chloro-4-(cyclopentyloxy)phenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(4′-fluoro-[1,1′-biphenyl]-4-yl)-2-oxoacetamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(4-(2-isopropyl-3-methyl-2H-indazol-5-yl)phenyl)-2-oxoacetamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(2-isopropyl-2H-indazol-5-yl)-2-oxoacetamide;

N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(2-isopropyl-2H-indazol-6-yl)-2-oxoacetamide;

N-((1R,2R)-1-(3-chloro-4-cyclobutoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(4′-fluoro-[1,1′-biphenyl]-4-yl)-2-oxoacetamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(4-(1-isopropyl-3-methyl-1H-indazol-5-yl)phenyl)-2-oxoacetamide;

2-(4′-fluoro-2′-methyl-[1,1′-biphenyl]-4-yl)-N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-oxoacetamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(2-isopropyl-2H-indazol-6-yl)-2-oxoacetamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(1-isopropyl-3-methyl-1H-indazol-5-yl)-2-oxoacetamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(4-(1,3-dimethyl-1H-indazol-5-yl)phenyl)-2-oxoacetamide;

N-((1R,2R)-1-(benzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(4′-fluoro-[1,1′-biphenyl]-4-yl)-2-oxoacetamide;

N-((1R,2R)-1-(3-chloro-4-(cyclopropylthio)phenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(4′-fluoro-[1,1′-biphenyl]-4-yl)-2-oxoacetamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(1-isopropyl-1H-indazol-5-yl)-2-oxoacetamide;

2-(4-(1,3-dimethyl-1H-indazol-5-yl)phenyl)-N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-oxoacetamide;

N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(1-isopropyl-1H-indol-5-yl)-2-oxoacetamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(1-isopropyl-1H-indol-5-yl)-2-oxoacetamide;

N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrrolidin-1-yl)propan-2-yl)-2-(4-morpholinophenyl)-2-oxoacetamide;

(S)—N-(1-(3-chloro-4-cyclopropoxyphenyl)-3-(pyrrolidin-1-yl)propan-2-yl)-2-(4′-fluoro-[1,1′-biphenyl]-4-yl)-2-oxoacetamide;

N-((1R,2R)-3-(azetidin-1-yl)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxypropan-2-yl)-2-oxo-2-(4-(pyrrolidin-1-yl)phenyl)acetamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-4-(6-chloronaphthalen-2-yl)-2,2-difluorobutanamide;

N-((1R,2R)-1-(3-chloro-4-(vinyloxy)phenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(4′-fluoro-[1,1′-biphenyl]-4-yl)-2-oxoacetamide;

N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(4-(1-isopropyl-1H-pyrazol-4-yl)phenyl)-2-oxoacetamide;

N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(1-isopropyl-1H-indol-6-yl)-2-oxoacetamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(1-isopropyl-1H-indol-6-yl)-2-oxoacetamide;

N-((1R,2R)-1-(4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(4′-fluoro-[1,1′-biphenyl]-4-yl)-2-oxoacetamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(4-(1-isopropyl-3-methyl-1H-indazol-6-yl)phenyl)-2-oxoacetamide;

N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(4-(2-isopropyl-3-methyl-2H-indazol-6-yl)phenyl)-2-oxoacetamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(4-(2-isopropyl-3-methyl-2H-indazol-6-yl)phenyl)-2-oxoacetamide;

N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(4-(1-isopropyl-3-methyl-1H-indazol-6-yl)phenyl)-2-oxoacetamide;

N-((1R,2R)-3-(azetidin-1-yl)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxypropan-2-yl)-2-(6-chlorobenzo[b]thiophen-2-yl)-2-oxoacetamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(4′-isopropyl-[1,1′-biphenyl]-4-yl)-2-oxoacetamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(4-(1,3-dimethyl-1H-indazol-6-yl)phenyl)-2-oxoacetamide;

2-(4-(1,3-dimethyl-1H-indazol-6-yl)phenyl)-N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-oxoacetamide;

2-(4-(2,3-dimethyl-2H-indazol-6-yl)phenyl)-N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-oxoacetamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-oxo-2-(4-(pyrrolidin-1-yl)phenyl)acetamide;

N-((1R,2R)-1-(3-fluoro-4-isopropoxy-5-methoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(4′-fluoro-[1,1′-biphenyl]-4-yl)-2-oxoacetamide;

N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(4-(1-isopropyl-1H-indol-6-yl)phenyl)-2-oxoacetamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(4-(1-isopropyl-1H-indol-6-yl)phenyl)-2-oxoacetamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(4-(2,3-dimethyl-2H-indazol-6-yl)phenyl)-2-oxoacetamide;

2-(6-chlorobenzo[b]thiophen-2-yl)-N-((1R,2R)-1-(3-fluoro-4-isopropoxy-5-methoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-oxoacetamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(4-(1-cyclopropyl-1H-pyrazol-3-yl)phenyl)-2-oxoacetamide;

2-(4-(1-cyclopropyl-1H-pyrazol-3-yl)phenyl)-N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-oxoacetamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(4-(1-isopropyl-1H-pyrazol-3-yl)phenyl)-2-oxoacetamide;

N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(4-(1-isopropyl-1H-pyrazol-3-yl)phenyl)-2-oxoacetamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(1-(4-fluorophenyl)-1H-indazol-5-yl)-2-oxoacetamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(2-(4-fluorophenyl)-2H-indazol-5-yl)-2-oxoacetamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-oxo-2-(4′-(prop-1-en-2-yl)-[1,1′-biphenyl]-4-yl)acetamide;

N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(4′-(2-hydroxypropan-2-yl)-[1,1′-biphenyl]-4-yl)-2-oxoacetamide;

N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(4′-isopropyl-[1,1′-biphenyl]-4-yl)-2-oxoacetamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(4′-(2-hydroxypropan-2-yl)-[1,1′-biphenyl]-4-yl)-2-oxoacetamide;

2-(4-(5-chlorothiophen-2-yl)phenyl)-N-((1R,2R)-1-(4-cyclopropoxy-3-fluorophenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-oxoacetamide;

2-(4-(5-chlorothiophen-2-yl)phenyl)-N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-oxoacetamide;

N-((1R,2R)-1-(3-fluoro-5-isopropoxy-4-methoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(4′-fluoro-[1,1′-biphenyl]-4-yl)-2-oxoacetamide;

N-((1R,2R)-1-(8-fluoro-3,3-dimethyl-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(4′-fluoro-[1,1′-biphenyl]-4-yl)-2-oxoacetamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(4-(5-chlorothiophen-2-yl)phenyl)-2-oxoacetamide;

2-(6-chlorobenzo[b]thiophen-2-yl)-N-((1R,2R)-1-(3-fluoro-5-isopropoxy-4-methoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-oxoacetamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(6-chlorobenzofuran-2-yl)-2-oxoacetamide;

2-(6-chlorobenzofuran-2-yl)-N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-oxoacetamide;

N-((1R,2R)-3-(azetidin-1-yl)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxypropan-2-yl)-2-oxo-2-(4-(pyrrolidin-1-yl)phenyl)acetamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(4-morpholinophenyl)-2-oxoacetamide;

N-((1R,2R)-3-(azetidin-1-yl)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxypropan-2-yl)-2-(4-morpholinophenyl)-2-oxoacetamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(4′-cyclopropyl-[1,1′-biphenyl]-4-yl)-2-oxoacetamide;

2-(4′-cyclopropyl-[1,1′-biphenyl]-4-yl)-N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-oxoacetamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-oxo-2-(4-(tetrahydro-2H-pyran-4-yl)phenyl)acetamide;

N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-oxo-2-(4-(tetrahydro-2H-pyran-4-yl)phenyl)acetamide;

N-((1R,2R)-1-(4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(4-morpholinophenyl)-2-oxoacetamide;

2-(4-(azetidin-1-yl)phenyl)-N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-oxoacetamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(4-fluorophenyl)-2-oxoacetamide;

2-(benzo[b]thiophen-2-yl)-N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-oxoacetamide;

N-((1R,2R)-1-(4-cyclopropoxy-3-fluorophenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(4-ethynylphenyl)-2-oxoacetamide;

N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(4-fluorophenyl)-2-oxoacetamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(1-(4-fluorophenyl)piperidin-4-yl)-2-oxoacetamide;

N-((1R,2R)-3-(azetidin-1-yl)-1-(4-cyclopropoxy-3-fluorophenyl)-1-hydroxypropan-2-yl)-2-(6-chlorobenzo[b]thiophen-2-yl)-2-oxoacetamide;

N-((1R,2R)-1-(4-cyclopropoxy-3-fluorophenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(4′-fluoro-[1,1′-biphenyl]-4-yl)-N-methyl-2-oxoacetamide; and

2-(6-chlorobenzo[b]thiophen-2-yl)-N-((1R,2R)-1-(4-cyclopropoxy-3-fluorophenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-N-methyl-2-oxoacetamide; and

optionally as a tautomer, a single stereoisomer or mixture of stereoisomers thereof and additionally optionally as a pharmaceutically acceptable salt thereof.

20. A pharmaceutical composition comprising i) a compound of claim 1 optionally as a tautomer, a single stereoisomer or mixture of stereoisomers thereof and additionally optionally as a pharmaceutically acceptable salt thereof, and ii) a pharmaceutically acceptable excipient or pharmaceutically acceptable carrier.

21. The compound of claim 1 , wherein the compound is selected from the group consisting of:

N-((1 S,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(5-chlorobenzofuran-2-yl)-2,2-difluoroacetamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(5-chlorobenzofuran-2-yl)-2,2-difluoroacetamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2,2-difluoro-4-(naphthalen-2-yl)butanamide;

2-(5-chloro-2,3-dihydro-1H-inden-2-yl)-N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2,2-di fluoroacetamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2,2-difluoro-2-(5-(trifluoromethyl)benzofuran-2-yl)acetamide;

N-((1S,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2,2-difluoro-2-(5-(trifluoromethyl)benzofuran-2-yl)acetamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(5-chlorobenzofuran-2-yl)-2-oxoacetamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2,2-difluoro-4-(6-fluoronaphthalen-2-yl)butanamide;

(E)-N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-4-(6-fluoronaphthalen-2-yl)-2-(hydroxyimino)butanamide;

N-((1R,2R)-3-(azetidin-1l-yl)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxypropan-2-yl)-2-(5-chlorobenzofuran-2-yl)-2-oxoacetamide;

N-((1R,2R)-1-(4-cyclopropoxy-3-fluorophenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2,2-difluoro-4-(naphthalen-2-yl)butanamide;

2-(5-chlorobenzofuran-2-yl)-N-((1R,2R)-1-(4-cyclopropoxy-3-fluorophenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2,2-difluoroacetamide;

N-((1R,2R)-3-(azetidin-1l-yl)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxypropan-2-yl)-2,2-difluoro-4-(6-fluoronaphthalen-2-yl)butanamide;

(E)-N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(5-chlorobenzofuran-2-yl)-2-(hydroxyimino)acetamide;

(E)-N-((1R,2R)-3-(azetidin-1-yl)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxypropan-2-yl)-4-(6-fluoronaphthalen-2-yl)-2-(hydroxyimino)butanamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(6-chloronaphthalen-2-yl)-2,2-difluoroacetamide;

(E)-N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(hydroxyimino)-4-(naphthalen-2-yl)butanamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-4-(naphthalen-2-yl)-2-oxobutanamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(4′-fluoro-[1,1′-biphenyl]-4-yl)-2-oxoacetamide;

(E)-N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2-(4′-fluoro-[1,1′-biphenyl]-4-yl)-2-(hydroxyimino)acetamide;

N-((1R,2R)-3-(azetidin-1-yl)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxypropan-2-yl)-4-(6-fluoronaphthalen-2-yl)-2-oxobutanamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2,2-difluoro-2-(4′-fluoro-[1,1′-biphenyl]-4-yl)acetamide;

N-((1R,2R)-3-(azetidin-1-yl)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxypropan-2-yl)-2,2-difluoro-2-(4′-fluoro-[1,1′-biphenyl]-4-yl)acetamide;

(E)-N-((1R,2R)-3-(azetidin-1-yl)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxypropan-2-yl)-2-(hydroxyimino)-4-(naphthalen-2-yl)butanamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-2,2-difluoro-4-(5,6,7,8-tetrahydronaphthalen-2-yl)butanamide;

(E)-N-((1R,2R)-3-(azetidin-1l-yl)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxypropan-2-yl)-2-(5-chlorobenzofuran-2-yl)-2-(hydroxyimino)acetamide;