Rehydration of micronized tecovirmimat monohydrate
View Patent ↗Disclosed are methods for hydration of ST-246 particles comprising exposing said particles to moisture by conveying volumes of air containing moisture.
1. A method of hydrating 4-trifluoromethyl-N-(3,3a,4,4a,5,5a,6,6a-octahydro-1,3-dioxo-4,6-ethenocycloprop[f]isoindol-2(1H)-yl)-benzamide (ST-246) that has been dehydrated during a micronization process, comprising: a) micronizing polymorph Form I monohydrate ST-246 particles to obtain partially dehydrated ST-246 polymorph Form I particles and/or ST-246 polymorph Form V hemihydrate particles; and b) hydrating said partially dehydrated ST-246 polymorph Form I particles and/or ST-246 polymorph Form V hemihydrate particles by exposing said particles to moisture by conveying volumes of air having greater than 30% relative humidity to said particles; wherein the hydrated ST-246 particles are polymorph Form I monohydrate.
2. The method of claim 1 , wherein the exposure of ST-246 particles to moisture takes place during a process selected from the group consisting of: high-throughput forced air, screen-dependent classifier, High Shear Granulation, Tray Drying, Vibratory sifter/sieve, Mixer/blender, and Fluid bed dryer.
3. The method of claim 1 , wherein the exposure of ST-246 particles to moisture takes place during high-throughput forced air, screen-dependent classifier.
4. The method of claim 1 , wherein the exposure by ST-246 particles to moisture takes place during high shear granulation.