IP Library › Granted Patent US 10,239,832

Granted Patent B2

US 10,239,832 · App. 15/032,613 · Granted Mar 26, 2019

N-(1-hydroxy-3-(pyrrolidinyl)propan-2-yl)pyrrolidine-3-carboxamide derivatives as glucosylceramide synthase inhibitors

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Patent No.: US 10,239,832
App. No.: 15/032,613
Granted: Mar 26, 2019
Kind: B2

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Abstract

Described herein are compounds of Formula I, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and compounds I for use to treat or prevent diseases or conditions associated with the enzyme glucosylceramide synthase (GCS).

Claims (444)

1. A compound of Formula I:

where

R 1 is N—(R 6 )-azetidinyl, N—(R 6 )-pyrrolidinyl, or N—(R 6 )-piperidinyl, each of which is attached to the C(O) group by a carbon atom and is optionally substituted with hydroxy;

R 2 and R 3 together with the nitrogen to which they are attached form a 4-6 membered heterocycloalkyl ring with 1 or 2 nitrogen atoms, which is optionally substituted with 1 or 2 R 8 ;

R 4 is aryl or heteroaryl each of which is optionally substituted with 1, 2, or 3 R 9 groups;

R 5 is halo, hydroxy, —N 3 , —NH 2 , —NHC(O)CH 3 , —NH(OCH 3 ), or —NHC(O)H and R 5a is hydrogen, halo, alkyl, or deuterium; or R 5 and R 5a together with the carbon to which they are attached form C(O) or C(NOH);

R 6 is alkyl, alkoxycarbonyl, aryl, arylalkyl, arylcarbonyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl, heterocycloalkylalkyl, heteroaryl, heteroarylalkyl, or —C(O)NR 6a R 6b ; wherein each aryl and heteroaryl, whether alone or as part of another group, is optionally substituted with 1 or 2 R 10 groups; and wherein each heterocycloalkyl and cycloalkyl, whether alone or as part of another group, is optionally substituted with 1 or 2 groups independently selected from hydroxy, halo, haloalkyl, alkoxy, alkyl, alkylcarbonyl, and alkoxycarbonyl;

R 6a is hydrogen or alkyl, and R 6b is aryl or heteroaryl each of which is optionally substituted with 1 or 2 halo; or R 6a and R 6b together with the nitrogen to which they are attached form a heterocycloalkyl optionally substituted with alkyl, hydroxy, alkylcarbonyl, or alkoxycarbonyl;

each R 8 , when present, is independently deuterium, amino, alkylamino, dialkylamino, alkyl, hydroxy, alkoxy, halo, haloalkyl, or cycloalkyl;

each R 9 , when present, is independently cyano, nitro, amino, alkylamino, dialkylamino, halo, haloalkyl, alkyl, —NR 11 C(O)NR 11a R 11b , hydroxy, alkoxy, haloalkoxy, hydroxyalkoxy, alkenyloxy, cycloalkyloxy, cycloalkylalkyloxy, cycloalkylthio, heterocycloalkyl, heterocycloalkyloxy, heterocycloalkylalkyloxy, or phenyl; where the phenyl is optionally substituted with 1 or 2 R 9a ; where each heterocycloalkyl, either alone or as part of another group, is optionally substituted with 1 or 2 groups independently selected from alkyl, hydroxy, alkylcarbonyl, and alkoxycarbonyl;

each R 9a , when present, is independently selected from alkyl, hydroxy, alkoxy, halo, haloalkyl, haloalkoxy, alkoxycarbonyl, amino, alkylamino, and dialkylamino;

each R 10 , when present, is independently cyano, nitro, amino, alkylamino, dialkylamino, halo, haloalkyl, alkyl, alkenyl, alkynyl, —NR 11 C(O)NR 11a R 11b , alkoxycarbonyl, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, cycloalkyl, hydroxy, alkoxy, haloalkoxy, hydroxyalkoxy, alkenyloxy, cycloalkyloxy, cycloalkylalkyloxy, cycloalkylthio, aryl, arylalkyl, aryloxy, heteroaryl, heteroarylalkyl, heteroaryloxy, heterocycloalkyl, heterocycloalkyloxy, or heterocycloalkylalkyloxy; where each aryl or heteroaryl either alone or as part of another group, is independently optionally substituted with 1, 2 or 3 R 10a ; and each heterocycloalkyl, either alone or as part of another group, is optionally substituted with 1 or 2 groups independently selected from alkyl, hydroxy, alkylcarbonyl, and alkoxycarbonyl groups;

each R 10a , when present, is independently selected from cyano, halo, alkyl, alkenyl, haloalkyl, hydroxyalkyl, and cycloalkyl; and

R 11 , R 11a , and R 11b are independently hydrogen, alkyl, or cycloalkyl; and

optionally a tautomer, a single stereoisomer or mixture of stereoisomers thereof and additionally optionally a pharmaceutically acceptable salt thereof.

2. The compound of claim 1 , which is according to Formula I(a):

optionally as a tautomer, a single stereoisomer or mixture of stereoisomers thereof and additionally optionally as a pharmaceutically acceptable salt thereof.

3. The compound of claim 1 , which is according to Formula I(d1):

optionally as a tautomer, a single stereoisomer or mixture of stereoisomers thereof and additionally optionally as a pharmaceutically acceptable salt thereof.

4. The compound of claim 1 , wherein R 5 is hydroxy and R 5a is hydrogen; optionally as a tautomer, a single stereoisomer or mixture of stereoisomers thereof and additionally optionally as a pharmaceutically acceptable salt thereof.

5. The compound of claim 1 , wherein R 6 is aryl, optionally independently substituted with 1 or 2 R 10 groups; optionally as a tautomer, a single stereoisomer or mixture of stereoisomers thereof and additionally optionally as a pharmaceutically acceptable salt thereof.

6. The compound of claim 1 , wherein R 6 is heterocycloalkyl or heteroaryl, each optionally substituted with 1 or 2 R 10 groups; optionally as a tautomer, a single stereoisomer or mixture of stereoisomers thereof and additionally optionally as a pharmaceutically acceptable salt thereof.

7. The compound of claim 1 , wherein:

R 4 is aryl or heteroaryl each of which is optionally substituted with 1 or 2 R 9 groups;

R 5 is hydroxy, and R 5a is hydrogen;

R 6 is alkyl, aryl, arylalkyl, arylcarbonyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl, heterocycloalkylalkyl, heteroaryl, or heteroarylalkyl; wherein each aryl and heteroaryl, whether alone or as part of another group, is optionally substituted with 1 or 2 R 10 groups; and wherein each heterocycloalkyl and cycloalkyl, whether alone or as part of another group, is optionally substituted with 1 or 2 groups independently selected from hydroxy, halo, haloalkyl, alkoxy, and alkyl;

each R 8 , when present, is independently alkyl, hydroxy, alkoxy, halo, or haloalkyl;

each R 9 , when present, is independently cyano, nitro, halo, haloalkyl, alkyl, hydroxy, alkoxy, haloalkoxy, hydroxyalkoxy, alkenyloxy, cycloalkyloxy, cycloalkylalkyloxy, cycloalkylthio, heterocycloalkyl, heterocycloalkyloxy, or heterocycloalkylalkyloxy; where each heterocycloalkyl, whether alone or as part of another group, is optionally substituted with 1 or 2 groups independently selected from alkyl, hydroxy, alkylcarbonyl, and alkoxycarbonyl;

each R 10 , when present, is independently is cyano, halo, haloalkyl, alkyl, hydroxy, alkoxy, haloalkoxy, cycloalkyloxy, cycloalkylalkyloxy, aryl, aryloxy, heteroaryloxy, heterocycloalkyl, heterocycloalkyloxy, or heterocycloalkylalkyloxy; where each aryl or heteroaryl either alone or as part of another group, is independently optionally substituted with 1 or 2 halo or alkyl groups; and each heterocycloalkyl, either alone or as part of another group, is optionally substituted with 1 or 2 groups independently selected from alkyl and hydroxy; and

optionally a tautomer, a single stereoisomer or mixture of stereoisomers thereof and additionally optionally a pharmaceutically acceptable salt thereof.

8. The compound of claim 1 , which is according to Formula I(c):

optionally as a tautomer, a single stereoisomer or mixture of stereoisomers thereof and additionally optionally as a pharmaceutically acceptable salt thereof.

9. The compound of claim 1 , which is according to Formula I(d2):

optionally as a tautomer, a single stereoisomer or mixture of stereoisomers thereof and additionally optionally as a pharmaceutically acceptable salt thereof.

10. The compound of claim 1 , wherein:

R 1 is N—(R 6 )-pyrrolidinyl attached to the C(O) by a carbon atom;

R 2 and R 3 together with the nitrogen to which they are attached form azetidinyl or pyrrolidinyl;

R 5 is hydroxy and R 5a is hydrogen; and optionally as a tautomer, a single stereoisomer or mixture of stereoisomers thereof and additionally optionally as a pharmaceutically acceptable salt thereof.

11. The compound of claim 1 , wherein R 6 is aryl or heteroaryl, wherein the aryl is optionally independently substituted with 1 or 2 halo, alkyl, cycloalkyloxy, or heterocycloalkyloxy; and the heteroaryl is optionally independently substituted with 1 or 2 halo, alkyl, or cycloalkyloxy; and optionally as a tautomer, a single stereoisomer or mixture of stereoisomers thereof and additionally optionally as a pharmaceutically acceptable salt thereof.

12. The compound of claim 1 , wherein R 6 is heterocycloalkyl optionally independently substituted with 1 or 2 halo, hydroxy, or alkyl; and optionally as a tautomer, a single stereoisomer or mixture of stereoisomers thereof and additionally optionally as a pharmaceutically acceptable salt thereof.

13. The compound of claim 1 , wherein the compound is selected from the group consisting of

(R)-1-(4-chlorophenyl)-N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)pyrrolidine-3-carboxamide;

1-(4-chlorophenyl)-N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)pyrrolidine-3-carboxamide;

(S)-1-(4-chlorophenyl)-N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)pyrrolidine-3-carboxamide;

(R)-1-(4-chlorophenyl)-N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)pyrrolidine-3-carboxamide;

1-(4-chlorophenyl)-N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)pyrrolidine-3-carboxamide;

(S)-1-(4-chlorophenyl)-N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)pyrrolidine-3-carboxamide;

(R)—N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-((4-hydroxytetrahydro-2H-pyran-4-yl)methyl)pyrrolidine-3-carboxamide;

N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-((4-hydroxytetrahydro-2H-pyran-4-yl)methyl)pyrrolidine-3-carboxamide;

(S)—N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-((4-hydroxytetrahydro-2H-pyran-4-yl)methyl)pyrrolidine-3-carboxamide;

(R)-1-(3,4-dichlorophenyl)-N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)pyrrolidine-3-carboxamide;

1-(3,4-dichlorophenyl)-N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)pyrrolidine-3-carboxamide;

(S)-1-(3,4-dichlorophenyl)-N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)pyrrolidine-3-carboxamide;

(R)—N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(tetrahydro-2H-pyran-4-yl)pyrrolidine-3-carboxamide;

N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(tetrahydro-2H-pyran-4-yl)pyrrolidine-3-carboxamide;

(S)—N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(tetrahydro-2H-pyran-4-yl)pyrrolidine-3-carboxamide;

1-cyclopentyl-N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)pyrrolidine-3-carboxamide;

(R)-1-(2,4-dichlorophenyl)-N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)pyrrolidine-3-carboxamide;

(S)-1-(2,4-dichlorophenyl)-N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)pyrrolidine-3-carboxamide;

(S)—N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(6-fluoronaphthalen-2-yl)pyrrolidine-3-carboxamide;

N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(6-fluoronaphthalen-2-yl)pyrrolidine-3-carboxamide;

(R)—N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(6-fluoronaphthalen-2-yl)pyrrolidine-3-carboxamide;

(R)-1-(4-chlorobenzyl)-N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)pyrrolidine-3-carboxamide;

1-(4-chlorobenzyl)-N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)pyrrolidine-3-carboxamide;

(S)-1-(4-chlorobenzyl)-N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)pyrrolidine-3-carboxamide;

(R)—N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(thiazol-2-yl)pyrrolidine-3-carboxamide;

(S)—N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(thiazol-2-yl)pyrrolidine-3-carboxamide;

1-(4-chloro-3-cyclopropoxyphenyl)-N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)pyrrolidine-3-carboxamide;

(R)-1-(3-chloro-4-cyclopropoxyphenyl)-N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)pyrrolidine-3-carboxamide;

1-(3-chloro-4-cyclopropoxyphenyl)-N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)pyrrolidine-3-carboxamide;

(S)-1-(3-chloro-4-cyclopropoxyphenyl)-N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)pyrrolidine-3-carboxamide;

(R)-1-(4-chlorophenethyl)-N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)pyrrolidine-3-carboxamide;

1-(4-chlorophenethyl)-N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)pyrrolidine-3-carboxamide;

(S)-1-(4-chlorophenethyl)-N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)pyrrolidine-3-carboxamide;

(R)—N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(pyridin-2-yl)pyrrolidine-3-carboxamide;

N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(pyridin-2-yl)pyrrolidine-3-carboxamide;

(S)—N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(pyridin-2-yl)pyrrolidine-3-carboxamide;

(R)—N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(4-fluorophenyl)pyrrolidine-3-carboxamide;

N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(4-fluorophenyl)pyrrolidine-3-carboxamide;

(S)—N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(4-fluorophenyl)pyrrolidine-3-carboxamide;

(R)—N-((1R,2R)-3-(azetidin-1-yl)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxypropan-2-yl)-1-(4-chlorophenyl)pyrrolidine-3-carboxamide;

(S)—N-((1R,2R)-3-(azetidin-1-yl)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxypropan-2-yl)-1-(4-chlorophenyl)pyrrolidine-3-carboxamide;

1-cyclohexyl-N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)pyrrolidine-3-carboxamide;

(R)-1-(5-chloropyridin-2-yl)-N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)pyrrolidine-3-carboxamide;

1-(5-chloropyridin-2-yl)-N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)pyrrolidine-3-carboxamide;

(S)-1-(5-chloropyridin-2-yl)-N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)pyrrolidine-3-carboxamide;

1-butyl-N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)pyrrolidine-3-carboxamide;

(R)—N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(4-fluorophenyl)pyrrolidine-3-carboxamide;

(S)—N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(4-fluorophenyl)pyrrolidine-3-carboxamide;

(R)—N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(4,5,6,7-tetrahydrobenzo[d]thiazol-2-yl)pyrrolidine-3-carboxamide;

N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(4,5,6,7-tetrahydrobenzo[d]thiazol-2-yl)pyrrolidine-3-carboxamide;

(S)—N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(4,5,6,7-tetrahydrobenzo[d]thiazol-2-yl)pyrrolidine-3-carboxamide;

(R)-1-(4-chlorophenyl)-N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(piperidin-1-yl)propan-2-yl)pyrrolidine-3-carboxamide;

1-(4-chlorophenyl)-N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(piperidin-1-yl)propan-2-yl)pyrrolidine-3-carboxamide;

(S)-1-(4-chlorophenyl)-N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(piperidin-1-yl)propan-2-yl)pyrrolidine-3-carboxamide;

(R)-1-(4-chlorophenyl)-N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(piperidin-1-yl)propan-2-yl)pyrrolidine-3-carboxamide;

(S)-1-(4-chlorophenyl)-N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(piperidin-1-yl)propan-2-yl)pyrrolidine-3-carboxamide;

(R)—N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(piperidin-1-yl)propan-2-yl)-1-(4-fluorophenyl)pyrrolidine-3-carboxamide;

N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(piperidin-1-yl)propan-2-yl)-1-(4-fluorophenyl)pyrrolidine-3-carboxamide;

(S)—N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(piperidin-1-yl)propan-2-yl)-1-(4-fluorophenyl)pyrrolidine-3-carboxamide;

(R)—N-((1R,2R)-3-(azetidin-1-yl)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxypropan-2-yl)-1-(6-fluoronaphthalen-2-yl)pyrrolidine-3-carboxamide;

N-((1R,2R)-3-(azetidin-1-yl)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxypropan-2-yl)-1-(6-fluoronaphthalen-2-yl)pyrrolidine-3-carboxamide;

(S)—N-((1R,2R)-3-(azetidin-1-yl)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxypropan-2-yl)-1-(6-fluoronaphthalen-2-yl)pyrrolidine-3-carboxamide;

(R)—N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(pyridin-2-yl)pyrrolidine-3-carboxamide;

(S)—N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(pyridin-2-yl)pyrrolidine-3-carboxamide;

(R)—N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(6-fluoronaphthalen-2-yl)pyrrolidine-3-carboxamide;

(S)—N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(6-fluoronaphthalen-2-yl)pyrrolidine-3-carboxamide;

(R)-1-(benzo[b]thiophen-6-yl)-N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)pyrrolidine-3-carboxamide;

1-(benzo[b]thiophen-6-yl)-N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)pyrrolidine-3-carboxamide;

(S)-1-(benzo[b]thiophen-6-yl)-N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)pyrrolidine-3-carboxamide;

(R)-1-(2,3-dihydro-1H-inden-2-yl)-N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)pyrrolidine-3-carboxamide;

1-(2,3-dihydro-1H-inden-2-yl)-N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)pyrrolidine-3-carboxamide;

(S)-1-(2,3-dihydro-1H-inden-2-yl)-N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)pyrrolidine-3-carboxamide;

(R)-1-(2-cyclopropoxypyridin-4-yl)-N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)pyrrolidine-3-carboxamide;

1-(2-cyclopropoxypyridin-4-yl)-N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)pyrrolidine-3-carboxamide;

(S)-1-(2-cyclopropoxypyridin-4-yl)-N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)pyrrolidine-3-carboxamide;

(R)-1-(6-cyclopropoxypyridin-3-yl)-N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)pyrrolidine-3-carboxamide;

(S)-1-(6-cyclopropoxypyridin-3-yl)-N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)pyrrolidine-3-carboxamide;

(R)—N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(1-methyl-1H-indazol-6-yl)pyrrolidine-3-carboxamide;

N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(1-methyl-1H-indazol-6-yl)pyrrolidine-3-carboxamide;

(S)—N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(1-methyl-1H-indazol-6-yl)pyrrolidine-3-carboxamide;

(R)—N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)pyrrolidine-3-carboxamide;

N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)pyrrolidine-3-carboxamide;

(S)—N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)pyrrolidine-3-carboxamide;

N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(2,2-dimethylchroman-6-yl)pyrrolidine-3-carboxamide;

(R)—N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(quinolin-2-yl)pyrrolidine-3-carboxamide;

(S)—N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(quinolin-2-yl)pyrrolidine-3-carboxamide;

(R)—N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(naphthalen-2-yl)pyrrolidine-3-carboxamide;

(S)—N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(naphthalen-2-yl)pyrrolidine-3-carboxamide;

(R)—N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(2,2-dimethylchroman-7-yl)pyrrolidine-3-carboxamide;

N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(2,2-dimethylchroman-7-yl)pyrrolidine-3-carboxamide;

(S)—N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(2,2-dimethylchroman-7-yl)pyrrolidine-3-carboxamide;

(R)—N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(quinolin-2-yl)pyrrolidine-3-carboxamide;

N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(quinolin-2-yl)pyrrolidine-3-carboxamide;

(S)—N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(quinolin-2-yl)pyrrolidine-3-carboxamide;

(R)-1-(2-chlorobenzo[b]thiophen-6-yl)-N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)pyrrolidine-3-carboxamide;

1-(2-chlorobenzo[b]thiophen-6-yl)-N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)pyrrolidine-3-carboxamide;

(S)-1-(2-chlorobenzo[b]thiophen-6-yl)-N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)pyrrolidine-3-carboxamide;

N-[2-(2H,3H-benzo[e]1,4-dioxan-6-yl)(1R,2R)-2-hydroxy-1-(pyrrolidinylmethyl)ethyl][1-(4-chlorophenyl)pyrrolidin-3-yl]carboxamide;

(R)—N-((1R,2R)-3-(azetidin-1-yl)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxypropan-2-yl)-1-(4-chlorophenyl)pyrrolidine-3-carboxamide;

(R)—N-((1R,2R)-3-(azetidin-1-yl)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxypropan-2-yl)-1-(6-fluoronaphthalen-2-yl)pyrrolidine-3-carboxamide;

N-((1R,2R)-3-(azetidin-1-yl)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxypropan-2-yl)-1-(6-fluoronaphthalen-2-yl)pyrrolidine-3-carboxamide;

(S)—N-((1R,2R)-3-(azetidin-1-yl)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxypropan-2-yl)-1-(6-fluoronaphthalen-2-yl)pyrrolidine-3-carboxamide;

(R)—N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(5,6,7, 8-tetrahydronaphthalen-2-yl)pyrrolidine-3-carboxamide;

N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(5,6,7,8-tetrahydronaphthalen-2-yl)pyrrolidine-3-carboxamide;

(S)—N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(5,6,7, 8-tetrahydronaphthalen-2-yl)pyrrolidine-3-carboxamide;

(R)—N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(naphthalen-2-yl)pyrrolidine-3-carboxamide;

(R)—N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(2,6-dimethylpyridin-4-yl)pyrrolidine-3-carboxamide;

(S)—N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(2,6-dimethylpyridin-4-yl)pyrrolidine-3-carboxamide;

(R)—N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(quinoxalin-6-yl)pyrrolidine-3-carboxamide;

N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(quinoxalin-6-yl)pyrrolidine-3-carboxamide;

(S)—N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(quinoxalin-6-yl)pyrrolidine-3-carboxamide;

(R)—N-((1R,2R)-3-(azetidin-1-yl)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxypropan-2-yl)-1-(naphthalen-2-yl)pyrrolidine-3-carboxamide;

(R)-1-(1-chloro-6-fluoronaphthalen-2-yl)-N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)pyrrolidine-3-carboxamide;

1-(1-chloro-6-fluoronaphthalen-2-yl)-N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)pyrrolidine-3-carboxamide;

(S)-1-(1-chloro-6-fluoronaphthalen-2-yl)-N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)pyrrolidine-3-carboxamide;

(R)—N-((1R,2R)-3-(azetidin-1-yl)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxypropan-2-yl)-1-(6-chloronaphthalen-2-yl)pyrrolidine-3-carboxamide;

N-((1R,2R)-3-(azetidin-1-yl)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxypropan-2-yl)-1-(6-chloronaphthalen-2-yl)pyrrolidine-3-carboxamide;

(S)—N-((1R,2R)-3-(azetidin-1-yl)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxypropan-2-yl)-1-(6-chloronaphthalen-2-yl)pyrrolidine-3-carboxamide;

(R)—N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(1,5-naphthyridin-3-yl)pyrrolidine-3-carboxamide;

(S)—N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(1,5-naphthyridin-3-yl)pyrrolidine-3-carboxamide;

(R)—N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(5,6,7, 8-tetrahydronaphthalen-2-yl)pyrrolidine-3-carboxamide;

(S)—N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(5,6,7, 8-tetrahydronaphthalen-2-yl)pyrrolidine-3-carboxamide;

(R)-1-(benzo[b]thiophen-6-yl)-N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)pyrrolidine-3-carboxamide;

(S)-1-(benzo[b]thiophen-6-yl)-N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)pyrrolidine-3-carboxamide;

(R)-1-(6-chloroquinolin-2-yl)-N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)pyrrolidine-3-carboxamide;

1-(6-chloroquinolin-2-yl)-N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)pyrrolidine-3-carboxamide;

(S)-1-(6-chloroquinolin-2-yl)-N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)pyrrolidine-3-carboxamide;

(R)-1-(6-chloroquinolin-2-yl)-N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)pyrrolidine-3-carboxamide;

(R)-1-(4-chloro-3-(pyridin-2-yloxy)phenyl)-N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)pyrrolidine-3-carboxamide;

(R)—N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(quinolin-7-yl)pyrrolidine-3-carboxamide;

(R)—N-((1R,2R)-3-(azetidin-1-yl)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxypropan-2-yl)-1-(2-chlorobenzo[b]thiophen-6-yl)pyrrolidine-3-carboxamide;

(R)-1-(4-chloro-3-(pyridin-2-yloxy)phenyl)-N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)pyrrolidine-3-carboxamide;

(R)-1-(2-chlorobenzo[b]thiophen-6-yl)-N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)pyrrolidine-3-carboxamide;

(R)-1-(6-(4-chlorophenoxy)pyridin-2-yl)-N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)pyrrolidine-3-carboxamide;

(R)-1-(6-(4-chlorophenoxy)pyridin-2-yl)-N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)pyrrolidine-3-carboxamide;

(R)—N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(6-(4-fluorophenoxy)pyridin-2-yl)pyrrolidine-3-carboxamide;

(R)—N-((1 R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(6-(4-fluorophenoxy)pyridin-2-yl)pyrrolidine-3-carboxamide;

(R)-1-benzoyl-N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)pyrrolidine-3-carboxamide;

(R)-1-benzoyl-N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)pyrrolidine-3-carboxamide;

(R)—N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(6-(4-fluorophenyl)pyridin-2-yl)pyrrolidine-3-carboxamide;

(R)—N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(6-(4-fluorophenyl)pyridin-2-yl)pyrrolidine-3-carboxamide;

(R)—N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(1-methyl-1H-indazol-5-yl)pyrrolidine-3-carboxamide;

(R)-1-(4-chlorophenyl)-N-((1R,2R)-1-(5-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)pyrrolidine-3-carboxamide;

(R)—N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(1-methyl-1H-indazol-6-yl)pyrrolidine-3-carboxamide;

(R)—N-((1R,2R)-3-(azetidin-1-yl)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxypropan-2-yl)-1-(1-methyl-1H-indazol-6-yl)pyrrolidine-3-carboxamide;

(R)-1-(4-chlorophenyl)-N-((1R,2R)-1-hydroxy-3-(pyrrolidin-1-yl)-1-(8-(trifluoromethyl)-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)propan-2-yl)pyrrolidine-3-carboxamide;

(R)-1-(4-(tert-butyl)phenyl)-N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)pyrrolidine-3-carboxamide;

(R)-1-(5-chloro-6-(4-fluorophenyl)pyridin-2-yl)-N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)pyrrolidine-3-carboxamide;

(S)-1-(4-chlorophenyl)-N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-3-hydroxypyrrolidine-3-carboxamide; and

(R)-1-(4-chlorophenyl)-N-((1R,2R)-1-(8-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-3-hydroxypyrrolidine-3-carboxamide;

and optionally as a tautomer, a single stereoisomer or mixture of stereoisomers thereof and additionally optionally as a pharmaceutically acceptable salt thereof.

14. The compound of claim 1 , wherein the compound is selected from the group consisting of:

(S)—N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(4-chlorophenyl)pyrrolidine-3-carboxamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(4-chlorophenyl)pyrrolidine-3-carboxamide;

(R)—N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(4-chlorophenyl)pyrrolidine-3-carboxamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(4-(trifluoromethyl)phenyl)pyrrolidine-3-carboxamide;

N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(4-(trifluoromethoxy)phenyl)pyrrolidine-3-carboxamide;

(R)—N-((1R,2R)-1-(3-chloro-4-isopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(4-chlorophenyl)pyrrolidine-3-carboxamide;

(S)—N-((1R,2R)-1-(3-chloro-4-isopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(4-chlorophenyl)pyrrolidine-3-carboxamide;

(R)—N-((1R,2R)-1-(3-chloro-4-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(4-fluorophenyl)pyrrolidine-3-carboxamide;

(S)—N-((1R,2R)-1-(3-chloro-4-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(4-fluorophenyl)pyrrolidine-3-carboxamide;

(R)—N-((1R,2R)-1-(3-chloro-4-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(4-chlorophenyl)pyrrolidine-3-carboxamide;

(S)—N-((1R,2R)-1-(3-chloro-4-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(4-chlorophenyl)pyrrolidine-3-carboxamide;

(R)—N-((1R,2R)-1-(3-chloro-4-((1-methylpiperidin-4-yl)oxy)phenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(4-chlorophenyl)pyrrolidine-3-carboxamide;

(S)—N-((1R,2R)-1-(3-chloro-4-((1-methylpiperidin-4-yl)oxy)phenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(4-chlorophenyl)pyrrolidine-3-carboxamide;

(R)—N-((1R,2R)-1-(3-chloro-4-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(6-fluoronaphthalen-2-yl)pyrrolidine-3-carboxamide;

(S)—N-((1R,2R)-1-(3-chloro-4-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(6-fluoronaphthalen-2-yl)pyrrolidine-3-carboxamide;

(R)—N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(pyridin-2-yl)pyrrolidine-3-carboxamide;

(S)—N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(pyridin-2-yl)pyrrolidine-3-carboxamide;

(R)—N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(5-chloropyridin-2-yl)pyrrolidine-3-carboxamide;

(S)—N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(5-chloropyridin-2-yl)pyrrolidine-3-carboxamide;

(R)—N-((1R,2R)-1-(3-chloro-4-(oxetan-3-yloxy)phenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(4-chlorophenyl)pyrrolidine-3-carboxamide;

(R)—N-((1R,2R)-1-(4-(2-(azetidin-1-yl)ethoxy)-3-chlorophenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(4-chlorophenyl)pyrrolidine-3-carboxamide;

(S)—N-((1R,2R)-1-(4-(2-(azetidin-1-yl)ethoxy)-3-chlorophenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(4-chlorophenyl)pyrrolidine-3-carboxamide;

(R)-1-(4-chlorophenyl)-N-((1R,2R)-1-(4-cyclopropoxy-3-fluorophenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)pyrrolidine-3-carboxamide;

(R)—N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(piperidin-1-yl)propan-2-yl)-1-(4-chlorophenyl)pyrrolidine-3-carboxamide;

(R)—N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(naphthalen-2-yl)pyrrolidine-3-carboxamide;

(S)—N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(naphthalen-2-yl)pyrrolidine-3-carboxamide;

(R)—N-((1R,2R)-1-(4-cyclopropoxy-3-fluorophenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(4-fluorophenyl)pyrrolidine-3-carboxamide;

(S)—N-((1R,2R)-1-(4-cyclopropoxy-3-fluorophenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(4-fluorophenyl)pyrrolidine-3-carboxamide;

(R)—N-((1R,2R)-3-(azetidin-1-yl)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxypropan-2-yl)-1-(4-chlorophenyl)pyrrolidine-3-carboxamide;

(R)—N-((1R,2R)-1-(3-chloro-4-morpholinophenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(4-chlorophenyl)pyrrolidine-3-carboxamide;

(S)—N-((1R,2R)-1-(3-chloro-4-morpholinophenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(4-chlorophenyl)pyrrolidine-3-carboxamide;

(R)—N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(3-(pyridin-2-yloxy)phenyl)pyrrolidine-3-carboxamide;

(S)—N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(3-(pyridin-2-yloxy)phenyl)pyrrolidine-3-carboxamide;

(R)—N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(6-fluoronaphthalen-2-yl)pyrrolidine-3-carboxamide;

(S)—N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(6-fluoronaphthalen-2-yl)pyrrolidine-3-carboxamide;

(R)—N-((1R,2R)-3-(azetidin-1-yl)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxypropan-2-yl)-1-(naphthalen-2-yl)pyrrolidine-3-carboxamide;

(R)—N-((1R,2R)-1-(3-chloro-4-(2-hydroxy-2-methylpropoxy)phenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(4-chlorophenyl)pyrrolidine-3-carboxamide;

(R)-1-(benzo[b]thiophen-6-yl)-N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)pyrrolidine-3-carboxamide;

(R)-1-(benzo[b]thiophen-6-yl)-N-((1R,2R)-1-(3-chloro-4-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)pyrrolidine-3-carboxamide;

(R)—N-((1R,2R)-1-(3-chloro-4-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(naphthalen-2-yl)pyrrolidine-3-carboxamide;

(R)—N-((1R,2R)-3-(azetidin-1-yl)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxypropan-2-yl)-1-(6-fluoronaphthalen-2-yl)pyrrolidine-3-carboxamide;

(R)—N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(4-fluorophenyl)pyrrolidine-3-carboxamide;

(R)—N-((1 R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(5,6,7,8-tetrahydronaphthalen-2-yl)pyrrolidine-3-carboxamide;

(S)—N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(5,6,7,8-tetrahydronaphthalen-2-yl)pyrrolidine-3-carboxamide;

(R)—N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(6-chloroquinolin-2-yl)pyrrolidine-3-carboxamide;

(R)—N-((1R,2R)-1-(3-chloro-4-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(2-chlorobenzo[b]thiophen-6-yl)pyrrolidine-3-carboxamide;

(R)—N-((1R,2R)-1-(3-chloro-4-(2-hydroxy-2-methylpropoxy)phenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(6-fluoronaphthalen-2-yl)pyrrolidine-3-carboxamide;

(R)-1-(4-chloro-3-(pyridin-2-yloxy)phenyl)-N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)pyrrolidine-3-carboxamide;

(R)—N-((1R,2R)-1-(3-chloro-4-(2-hydroxy-2-methylpropoxy)phenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(naphthalen-2-yl)pyrrolidine-3-carboxamide;

(R)—N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(2-chlorobenzo[b]thiophen-6-yl)pyrrolidine-3-carboxamide;

(R)—N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(6-(4-chlorophenoxy)pyridin-2-yl)pyrrolidine-3-carboxamide;

(R)—N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(6-(4-fluorophenoxy)pyridin-2-yl)pyrrolidine-3-carboxamide;

(R)—N-((1R,2R)-1-(3-chloro-4-(oxetan-3-yloxy)phenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(6-fluoronaphthalen-2-yl)pyrrolidine-3-carboxamide;

(R)—N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(2-chloro-5-(pyridin-2-yloxy)phenyl)pyrrolidine-3-carboxamide;

(R)—N-((1R,2R)-3-(azetidin-1-yl)-1-(3-chloro-4-(oxetan-3-yloxy)phenyl)-1-hydroxypropan-2-yl)-1-(6-fluoronaphthalen-2-yl)pyrrolidine-3-carboxamide;

(R)—N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(6-(4-fluorophenyl)pyridin-2-yl)pyrrolidine-3-carboxamide;

(R)—N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(1-methyl-1H-indazol-5-yl)pyrrolidine-3-carboxamide;

(R)-1-(4-chloro-3-(4-fluorophenoxy)phenyl)-N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)pyrrolidine-3-carboxamide;

(R)-1-benzoyl-N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)pyrrolidine-3-carboxamide;

(R)-1-(4-chloro-3-((6-methylpyridin-2-yl)oxy)phenyl)-N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)pyrrolidine-3-carboxamide;

(R)—N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(1-methyl-1H-indazol-6-yl)pyrrolidine-3-carboxamide;

(R)—N-((1R,2R)-1-(4-(tert-butoxy)-3-chlorophenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(4-chlorophenyl)pyrrolidine-3-carboxamide;

(R)-1-(4-chloro-3-(cyclohexyloxy)phenyl)-N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)pyrrolidine-3-carboxamide;

(R)-1-(6-chloro-4′-fluoro-[1,1′-biphenyl]-3-yl)-N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)pyrrolidine-3-carboxamide;

(R)-1-(4-(tert-butyl)phenyl)-N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)pyrrolidine-3-carboxamide;

(R)—N-((1R,2R)-1-(3-chloro-4-cyclobutoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(4-chlorophenyl)pyrrolidine-3-carboxamide;

(R)—N-((1R,2R)-1-(3-chloro-4-(cyclopentyloxy)phenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(4-chlorophenyl)pyrrolidine-3-carboxamide;

(R)—N-((1R,2R)-1-(3-chloro-4-(cyclopropylthio)phenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(4-chlorophenyl)pyrrolidine-3-carboxamide;

(R)—N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(5-chloro-6-(4-fluorophenyl)pyridin-2-yl)pyrrolidine-3-carboxamide;

(R)—N-((1 R,2R)-1-(3-chloro-4-(vinyloxy)phenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(4-chlorophenyl)pyrrolidine-3-carboxamide;

(R)—N-((1R,2R)-1-(4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(4-fluorophenyl)pyrrolidine-3-carboxamide;

(R)—N-((1R,2R)-1-(4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-phenylpyrrolidine-3-carboxamide;

(R)—N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-phenylpyrrolidine-3-carboxamide;

(R)—N-((1R,2R)-1-(4-cyclopropoxy-3-fluorophenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-phenylpyrrolidine-3-carboxamide;

(R)—N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(4-cyanophenyl)pyrrolidine-3-carboxamide;

(S)—N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(4-cyanophenyl)pyrrolidine-3-carboxamide;

(R)—N-((1R,2R)-1-(3-chloro-4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(p-tolyl)pyrrolidine-3-carboxamide;

(R)-1-(4-chlorophenyl)-N-((1R,2R)-1-(4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)pyrrolidine-3-carboxamide;

(R)-1-(4-chlorophenyl)-N-((1R,2R)-1-(4-chlorophenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)pyrrolidine-3-carboxamide;

(R)-1-(benzo[b]thiophen-6-yl)-N-((1R,2R)-1-(4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)pyrrolidine-3-carboxamide;

(R)—N-((1R,2R)-3-(azetidin-1-yl)-1-(4-cyclopropoxyphenyl)-1-hydroxypropan-2-yl)-1-(benzo[b]thiophen-6-yl)pyrrolidine-3-carboxamide;

(R)—N-((1R,2R)-3-(azetidin-1-yl)-1-(4-cyclopropoxyphenyl)-1-hydroxypropan-2-yl)-1-(6-fluoronaphthalen-2-yl)pyrrolidine-3-carboxamide;

(S)—N-((1R,2R)-3-(azetidin-1-yl)-1-(4-cyclopropoxyphenyl)-1-hydroxypropan-2-yl)-1-(6-fluoronaphthalen-2-yl)pyrrolidine-3-carboxamide;

(R)-1-(4-chlorophenyl)-N-((1R,2R)-1-(4-(difluoromethoxy)phenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)pyrrolidine-3-carboxamide;

(R)—N-((1 R,2R)-1-(4-(difluoromethoxy)phenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-phenylpyrrolidine-3-carboxamide; and

(R)—N-((1R,2R)-1-(4-cyclopropoxyphenyl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)-1-(6-fluoronaphthalen-2-yl)pyrrolidine-3-carboxamide;

and optionally as a tautomer, a single stereoisomer or mixture of stereoisomers thereof and additionally optionally as a pharmaceutically acceptable salt thereof.

15. The compound of claim 1 , wherein the compound is selected from the group consisting of: