IP Library Granted Patent US 10,086,183
Granted Patent B2
US 10,086,183 · App. 15/032,709 · Granted Oct 2, 2018

Applicator

Inventors: Shunsuke Arami (Tsukuba, JP); Shinpei Nishimura (Tsukuba, JP); Seiji Tokumoto (Tsukuba, JP); Makoto Ogura (Tsukuba, JP)
Assignee: HISAMITSU PHARMACEUTICAL CO., INC.
A61M37/0015A61M2037/0023A61M2037/0046A61M2037/0061
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Quick Facts
Patent No.
US 10,086,183
App. No.
15/032,709
Granted
Oct 2, 2018
Kind
B2
Abstract

An applicator is configured to transfer an active ingredient into a body through skin by a puncture in the skin with microneedles. The applicator includes a piston plate that is provided with a first protrusion part and second protrusion parts on a lower surface side of a main body of the piston plate. The microneedles are provided on a surface of the first protrusion part. The second protrusion parts are provided in a periphery of the first protrusion part while spaced apart from the first protrusion part.

Claims (28)

1. An applicator configured to transfer an active ingredient into a body through skin by a puncture in the skin with microneedles, the applicator comprising:

a casing;

a piston plate housed in a main body part of the casing and movable in a top-bottom direction inside of the main body part, wherein

the piston plate comprises a lower surface including:

a microneedle region where a first protrusion part is located, the microneedles being provided in the first protrusion part;

at least one second protrusion part provided in a periphery of the microneedle region; and

a recessed part formed between the first protrusion part and the at least one second protrusion part, and recessed from both of a surface of the first protrusion part and a surface of each of the at least one second protrusion parts, wherein

a plurality of the second protrusion parts are provided on the piston plate, and

the plurality of the second protrusion parts being disposed in such a way as to surround the first protrusion part.

2. The applicator according to claim 1 , wherein

an adhesive substance with adhesive capability is provided in at least a part of the surface of the second protrusion part.

3. The applicator according to claim 1 , wherein

a difference in height between a leading end surface of the at least one second protrusion part and a leading end of the microneedle protruding outward from the leading end surface is 0 mm or more.

4. The applicator according to claim 3 , wherein

the difference in height is 0 to 1.0 mm.

5. The applicator according to claim 3 , wherein

a value D/F is not less than 0.0 and not more than 1.4, where D is the difference in height, and F is an average length of the microneedles.

6. The applicator according to claim 5 , wherein

the value D/F is not less than 1.0 and not more than 1.4.

7. An applicator configured to transfer an active ingredient into a body through skin by a puncture in the skin with microneedles, the applicator comprising:

a casing;

a piston plate housed in a main body part of the casing and movable in a top-bottom direction inside of the main body part, wherein

the piston plate comprises a lower surface that transmits impact force to a microneedle array in which the microneedles are provided in a predetermined region by colliding against the microneedle array,

at least one protrusion part that is provided in the lower surface of the piston plate in such a way as to surround the microneedle array while spaced apart from the predetermined region of the microneedle array, and

a portion between the predetermined region of the microneedle array and the at least one protrusion part forms a recessed part recessed from both of a surface of the predetermined region and a surface of each of the at least one protrusion parts, wherein

a plurality of the protrusion parts are provided on the piston plate, and the plurality of the protrusion parts are disposed in such a way as to surround the microneedle array.

8. The applicator according to claim 7 , wherein

an adhesive substance with adhesive capability is provided in at least a part of the surface of the protrusion part.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 7, 2016
From: ARAMI, SHUNSUKE; NISHIMURA, SHINPEI; TOKUMOTO, SEIJI; OGURA, MAKOTO
To: HISAMITSU PHARMACEUTICAL CO., INC.
Reel/Frame 038830/0056 →
Priority Claims (1)
JP 2013-229691 · Nov 5, 2013 · national
Continuity (1)
Related Publication 20160263363A1 · Sep 15, 2016