IP Library Granted Patent US 10,543,293
Granted Patent B2
US 10,543,293 · App. 15/034,159 · Granted Jan 28, 2020

Medical dressing

Inventor: Christoph V. Suschek (Langenfeld, DE)
Assignee: BSN medical GmbH
A61L15/18A61F13/00029A61F13/00063A61F13/02A61L15/20A61L15/44A61M35/00A61L2300/114A61M2202/0275
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Quick Facts
Patent No.
US 10,543,293
App. No.
15/034,159
Granted
Jan 28, 2020
Kind
B2
Abstract

The present invention relates to a medical dressing that has a modular structure consisting of at least two layers and that is able to cleave incorporated photolabile nitric oxide donors in an adjoining absorption module by means of the emission of electromagnetic radiation from a light module, so that the photolytically generated nitric oxide can be used to enhance medical therapies in humans and animals as well as to generate NO.

Claims (52)

1. A medical dressing comprising:

a nitric oxide module containing one or more photolabile nitric oxide donors;

a radiation-emitting module including a source of radiation, said radiation-emitting module being configured such that electromagnetic radiation emitted from the source cleaves the nitric oxide donors in the nitric oxide module and thereby generates nitric oxide for release from the nitric oxide module; and

a radical trapping system configured to degrade or neutralize one or more reactive intermediate products of light-induced nitric oxide donor decomposition selected from the group consisting of polyoxidized nitrogen oxides, oxygen radical anions, hydrated electrons and hydroxyl radicals;

wherein the medical dressing comprises an outer layer, a middle layer and an inner layer,

wherein the outer layer is impermeable for nitric oxide,

wherein the one or more photolabile nitric oxide donors are present in the middle layer, and

wherein the radical trapping system is present in the inner layer.

2. The medical dressing according to claim 1 , further comprising transition metal cations.

3. The medical dressing according to claim 2 , wherein the transition metal cations are Cu 2+ ions.

4. The medical dressing according to claim 1 , wherein the electromagnetic radiation emitted from the radiation-emitting module has a wavelength ranging from 400 nm to 470 nm.

5. The medical dressing according to claim 1 , wherein the radical trapping system is selected from the group consisting of:

ascorbic acid;

ascorbate;

vitamin E

derivatives of vitamin E

thiols

radical traps;

enzymes that break down oxygen species; and

enzymes that break down nitrogen species.

6. The medical dressing according to claim 1 , wherein the medical dressing is a medical wound dressing.

7. The medical dressing according to claim 1 , wherein the nitric oxide module is permanently joined to the radiation-emitting module.

8. The medical dressing according to claim 1 , wherein the nitric oxide module is arranged a predetermined distance away from the radiation-emitting module.

9. The medical dressing according to claim 1 , wherein the nitric oxide module is configured in the form of a replaceable and disposable article.

10. The medical dressing according to claim 1 , wherein the source of electromagnetic radiation of the radiation-emitting module is installed in a housing together with an electronic control unit for the electromagnetic radiation source.

11. The medical dressing according to claim 1 , wherein the source of electromagnetic radiation of the radiation-emitting module is physically separated from an electronic control unit for the source of electromagnetic radiation, and wherein control is carried out via a wired connection or by a remote wireless connection.

12. The medical dressing according to claim 1 , wherein the source of electromagnetic radiation is selected from the group comprising a glow-discharge or gas-discharge lamp (low-pressure discharging or high-pressure discharging) coated with appropriate fluorochromes, a light-emitting diode (LED), an organic light-emitting diode (OLED) and a laser.

13. The medical dressing according to claim 1 , wherein the one or more photolabile nitric oxide donors is selected from the group consisting of organic nitrates, inorganic nitrates, nitrites, sulfur-nitroso compounds, nitrogen-nitroso compounds, oxygen-nitroso compounds, NO-metal compounds and NO-chelating substances.

14. The medical dressing according to claim 1 , wherein the one or more photolabile nitric oxide donors is an inorganic nitrite.

15. The medical dressing according to claim 1 , wherein the one or more photolabile nitric oxide donors is selected from the group consisting of LiNO 2 , NaNO 2 , KNO 2 , RbNO 2 , CsNO 2 , FrNO 2 , Be(NO 2 ) 2 , Mg(NO 2 ) 2 , Ca(NO 2 ) 2 , Sr(NO 2 ) 2 , Ba(NO 2 ) 2 and Ra(NO 2 ) 2 .

16. The medical dressing according to claim 1 , wherein the photolabile nitric oxide donors includes NaNO 2 and the radical trapping system includes ascorbic acid or ascorbate.

17. The medical dressing according to claim 1 , further comprising a safety-relevant and treatment-relevant sensor system.

18. The medical dressing according to claim 17 , wherein the safety-relevant and treatment-relevant sensor system is for NO, NO 2 , temperature, light intensity, skin reddening, or time switch-OFF.

19. A method for treatment of a human body comprising placing or adhering a medical dressing according to claim 1 onto a region that is to be treated.

20. The method according to claim 19 , wherein the treatment is selected from the group comprising:

treatment of diabetic feet and wounds;

treatment of neuropathic pain;

treatment of varicose veins;

treatment of local superficial as well as deep ischemias and thrombopathic diseases of tissues;

treatment of acute and chronic inflammation of skin;

treatment of skin allergies;

treatment of parasitic infections of skin;

treatment of atopic dermatitis;

treatment of wound defects;

treatment of infected wounds healing by second intention;

treatment of wounds healing by first intention;

treatment of high blood pressure (hypertonia) and related hemodynamic diseases;

treatment of patients with skin transplants;

treatment of diabetic pain in lower extremities; and

treatment in cases of poorly perfused skin flap plastic surgeries.

21. The method according to claim 19 , wherein the treatment is for chronic wounds in lower extremities of diabetic patients.

22. The method according to claim 19 , wherein the treatment lasts for a period between 5 and 30 minutes.

Assignments (3)
MERGER Recorded Jul 12, 2017
From: BSN MEDICAL GMBH
To: BSN MEDICAL HOLDING GMBH
Reel/Frame 042982/0393 →
CHANGE OF NAME Recorded Jul 12, 2017
From: BSN MEDICAL HOLDING GMBH
To: BSN MEDICAL GMBH
Reel/Frame 043164/0268 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 9, 2016
From: SUSCHEK, CHRISTOLPH V.
To: BSN MEDICAL GMBH
Reel/Frame 038863/0593 →
Priority Claims (1)
DE 10 2013 018 642 · Nov 7, 2013 · national
Continuity (1)
Related Publication 20160296655A1 · Oct 13, 2016
Cited By (2)
US 12,290,655 US 12,458,540