Aqueous suspension preparation comprising nanoparticles of macrolide antibacterial agent
An aqueous suspension preparation that comprises a macrolide antibacterial agent as an active component. The aqueous suspension preparation is characterized by comprising nanoparticles of a macrolide antibacterial agent and a dispersion stabilizer; an aqueous suspension in which the average particle size of nanoparticles is 500 nm or less and the D90 particle size is 1,500 nm or less; a parenterally administered pharmaceutical composition that comprises this aqueous suspension preparation; an injection preparation; and eye drops or ear drops, more specifically, eye drops for the treatment or prevention of inflammatory diseases of the eye or ear drops for the treatment or prevention of inflammatory diseases of the ear.
1. An aqueous suspension formulation comprising:
nanoparticles consisting essentially of a macrolide antibiotic; and
a dispersion stabilizer comprising polyoxyethylene hydrogenated castor oil,
wherein the nanoparticles have an average particle diameter of 500 nm or less and a 90% diameter of 1500 nm or less.
2. The aqueous suspension formulation of claim 1 , wherein the nanoparticles are produced by mixing the macrolide antibiotic, a physiologically acceptable salt and/or a physiologically acceptable saccharide, a physiologically acceptable polyol and/or water, and the dispersion stabilizer.
3. The aqueous suspension formulation of claim 1 , wherein the macrolide antibiotic is erythromycin, clarithromycin, roxithromycin, azithromycin, josamycin, rokitamycin, or kitasamycin.
4. The aqueous suspension formulation of claim 1 , wherein the dispersion stabilizer further comprises a surfactant, an aggregation inhibitor, or a viscosity modifier.
5. The aqueous suspension formulation of claim 4 , wherein the surfactant is polysorbate 80, polyethylene glycol monostearate, and/or polyoxyethylene polyoxypropylene glycol.
6. The aqueous suspension formulation of claim 4 , wherein the aggregation inhibitor is polyvinyl alcohol, polyethylene glycol, lecithin, and/or polyvinylpyrrolidone.
7. The aqueous suspension formulation of claim 4 , wherein the viscosity modifier is methyl cellulose, hydroxypropyl methyl cellulose, and/or hydroxyethyl cellulose.
8. The aqueous suspension formulation of claim 1 , which has a low irritability.
9. A pharmaceutical composition comprising the aqueous suspension formulation of claim 1 .
10. A kit containing nanoparticles consisting essentially of a macrolide antibiotic for preparing a pharmaceutical composition comprising the nanoparticles of a macrolide antibiotic, wherein the nanoparticles have an average particle diameter of 500 nm or less and a 90% diameter of 1500 nm or less, and wherein the kit further contains a dispersion stabilizer comprising polyoxyethylene hydrogenated castor oil.
11. A method for treating or preventing an inflammatory disease or an infectious disease in a subject in need thereof, comprising administering the aqueous suspension formulation of claim 1 to the subject.
12. The method of claim 11 , wherein the aqueous suspension formulation is administered parenterally.
13. The method of claim 12 , wherein the aqueous suspension formulation is administered topically or by injection.
14. The method of claim 13 , wherein the aqueous suspension formulation is topically administered to eye, ear, nose, or lung.
15. The method of claim 14 , wherein the aqueous suspension formulation is administered in the form of an eye drop, an ear drop, a nose drop, or an inhaler.
16. The method of claim of claim 11 , wherein the inflammatory disease or the infectious disease is systemic.
17. The method of claim of claim 11 , wherein the inflammatory disease or the infectious disease is an inflammatory disease or an infectious disease of eye, ear, nose, and lung.
18. The aqueous suspension formulation of claim 1 , wherein the macrolide antibiotic is clarithromycin, roxithromycin, azithromycin, josamycin, rokitamycin, or kitasamycin.
19. The aqueous suspension formulation of claim 1 , wherein the macrolide antibiotic is clarithromycin.