Methods for treating of skin conditions with retinoid double conjugate compounds
A double conjugate molecule made of a retinoid, an organic acid, particularly an a-hydroxy acid, and an alcohol or acyl group, is provided which is useful in treating skin conditions, particularly aging. The retinoid, organic acid, and alcohol/acyl group are preferably linked via ester bonds.
1. A method of treating a skin condition in a human, comprising:
contacting the skin of the human in need of such treatment with an effective amount of a composition comprising the molecule of formula (Id),
wherein
R 3 is H or alkyl consisting of 1 carbon atom, and
R 6 is alkyl consisting of 1, 2, 3, or 4 carbon atoms; and
wherein the skin condition is acne, photodamage, fine lines and wrinkles, or a combination thereof.
2. The method of claim 1 , wherein the composition further comprises:
a carrier; and
0.01 to 0.5 wt %, relative to the total weight of the composition, of the molecule of formula Id.
3. The method of claim 1 , wherein the composition further comprises:
an α-hydroxy acid.
4. The method of claim 1 , wherein the molecule has the formula (If)
5. The method of claim 1 , wherein the molecule has the formula (Ig)
6. The method of claim 1 , wherein the molecule of formula (Id) is present in an amount of 0.01 to 0.25 wt %.
7. The method of claim 1 , wherein the molecule of formula (Id) is present in an amount of 0.01 to less than 0.2 wt %.
8. The method of claim 1 , wherein the molecule of formula (Id) is present in the amount of 0.02 to 0.175 wt %.