Protein kinase inhibitors
View Patent ↗The present invention relates to a novel family of protein kinase inhibitors of Formula I: as well as to the processes of preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative, inflammatory, autoimmune or infectious diseases, disorders, or conditions in which protein kinase activity is implicated.
1. A compound of Formula I:
or pharmaceutically acceptable salt, solvate, solvate of salt, stereoisomer, tautomer, isotope, or complex thereof, wherein
X is
1) CH;
R is
1) hydrogen,
2) alkyl,
3) heteroalkyl,
4) carbocyclyl,
5) heterocyclyl,
6) aryl, or
7) heteroaryl,
wherein the alkyl, heteroalkyl, carbocyclyl, heterocyclyl, aryl, or heteroaryl are optionally substituted;
Y is
E is oxygen;
Z is
W is
1)—OCH 2 R 1 or
2)—CH 2 OR 1 ,
wherein Y-E-Z-W is
R 1 is substituted or unsubstituted 5-membered heteroaryl;
X 1 and X 2 are independently hydrogen or halogen;
m is an integer from 0 to 4;
m′ is an integer from 0 to 4.
2. The compound according to claim 1 , wherein R is selected from the group consisting of:
3. The compound according to claim 1 , wherein Z is
4. The compound according to claim 1 , wherein Y is
5. The compound according to claim 1 , wherein W is
6. A compound of Formula II:
or a pharmaceutically acceptable salt, solvate, solvate of salt, stereoisomer, tautomer, isotope, or complex thereof wherein R is selected from the group consisting of:
1) hydrogen,
2) alkyl,
3) heteroalkyl,
4) carbocyclyl,
5) heterocyclyl,
6) aryl, or
7) heteroaryl,
wherein the alkyl, heteroalkyl, carbocyclyl, heterocyclyl, aryl, or heteroaryl are optionally substituted;
wherein W is selected from the group consisting of:
7. The compound according to claim 6 , wherein R is selected from the group consisting of:
8. A compound selected from the group consisting of:
Com-
pound
Structure
1
2
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22
23
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35
or pharmaceutically acceptable salt, solvate, solvate of salt, stereoisomer, tautomer, isotope, or complex thereof.
9. A process for producing a compound according to claim 1 , wherein the process comprises the following steps:
10. A process for producing a compound according to claim 1 , wherein the process comprises the following steps:
11. A pharmaceutical composition comprising a compound according to claim 1 , or a pharmaceutically acceptable salt, solvate, solvate of salt, stereoisomer, tautomer, isotope, or complex thereof, and at least one pharmaceutically acceptable carrier, diluents, or excipient.
12. A compound of Formula I:
or pharmaceutically acceptable salt, solvate, solvate of salt, stereoisomer, tautomer, isotope, or complex thereof, wherein
X is
1) CH;
R is
1) hydrogen,
2) alkyl,
3) heteroalkyl,
4) carbocyclyl,
5) heterocyclyl,
6) aryl, or
7) heteroaryl,
wherein the alkyl, heteroalkyl, carbocyclyl, heterocyclyl, aryl, or heteroaryl are optionally substituted;
Y is
E is oxygen;
Z is
W is
1)—OCH 2 R 1 or
2)—CH 2OR 1,
wherein Y-E-Z W is
R 1 is substituted or unsubstituted aryl;
X 1 and X 2 are independently hydrogen or halogen;
m is an integer from 0 to 4;
m′ is an integer from 0 to 4.
13. The compound according to claim 12 , wherein R is selected from the group consisting of:
14. The compound according to claim 12 , wherein Z is
15. The compound according to claim 12 , wherein Y is
16. The compound according to claim 12 , wherein W is
17. A compound of Formula I:
or pharmaceutically acceptable salt, solvate, solvate of salt, stereoisomer, tautomer, isotope, or complex thereof, wherein
X is
1) CH;
R is
1) hydrogen,
2) alkyl,
3) heteroalkyl,
4) carbocyclyl,
5) heterocyclyl,
6) aryl, or
7) heteroaryl,
wherein the alkyl, heteroalkyl, carbocyclyl, heterocyclyl, aryl, or heteroaryl are optionally substituted;
Y is
E is oxygen;
Z is
W is
1)—OCH 2 R 1 or
2)—CH 2 OR 1 ,
wherein Y-E-Z-W is
R 1 is substituted or unsubstituted 6-membered heteroaryl;
X 1 and X 2 are independently hydrogen or halogen;
m is an integer from 0 to 4;
m′ is an integer from 0 to 4.
18. The compound according to claim 17 , wherein R is selected from the group consisting of:
19. The compound according to claim 17 , wherein Z is
20. The compound according to claim 17 , wherein Y is
21. The compound according to claim 1 , wherein W is selected from the group consisting of