IP Library › Granted Patent US 10,098,865
Granted Patent B2
US 10,098,865 · App. 15/045,077 · Granted Oct 16, 2018

Multi-arm polymeric prodrug conjugates of taxane-based compounds

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Quick Facts
Patent No.
US 10,098,865
App. No.
15/045,077
Granted
Oct 16, 2018
Kind
B2
Abstract

Among other aspects, provided herein are multi-arm polymeric prodrug conjugates of taxane-based compounds and/or fluorinated forms thereof. Methods of preparing such conjugates as well as methods of administering the conjugates are also provided. Upon administration to a patient, release of the taxane-based compound is achieved.

Claims (4)

1. A conjugate of formula:

wherein n is a positive integer from 10 to about 400, or a pharmaceutically acceptable salt thereof.

2. A composition comprising a plurality of conjugates, wherein at least 80% of the conjugates in the composition have a structure encompassed by claim 1 .

3. The composition of claim 2 , further comprising a pharmaceutical excipient.

Assignments (2)
RELEASE OF SECURITY INTEREST Recorded Apr 17, 2020
From: TC LENDING, LLC, AS COLLATERAL AGENT
To: NEKTAR THERAPEUTICS
Reel/Frame 053180/0009 →
SECURITY INTEREST Recorded Apr 13, 2016
From: NEKTAR THERAPEUTICS
To: TC LENDING, LLC, AS COLLATERAL AGENT
Reel/Frame 038339/0132 →