IP Library › Granted Patent US 9,687,443
Granted Patent B2
US 9,687,443 · App. 15/048,607 · Granted Jun 27, 2017

Compositions containing alpha-2-adrenergic agonist components

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Quick Facts
Patent No.
US 9,687,443
App. No.
15/048,607
Granted
Jun 27, 2017
Kind
B2
Abstract

Compositions useful for improving effectiveness of alpha-2-adrenergic agonist components include carrier components, alpha-2-adrenergic agonist components, solubility enhancing components which aid in solubilizing the alpha-2-adrenergic agonist components. In one embodiment, the alpha-2-adrenergic agonist components include alpha-2-adrenergic agonists. In another embodiment, the solubility enhancing components include carboxymethylcellulose.

Claims (12)

1. A therapeutically effective aqueous ophthalmic composition comprising:

a solution containing 0.1% (w/v) of a compound selected from the group consisting of brimonidine, a salt of brimonidine, and an ester of brimonidine,

wherein the solution further comprises an oxy-chloro preservative and carboxymethylcellulose,

wherein the composition has a pH between 7.0-8.0.

2. The composition of claim 1 which comprises about 0.1% (w/v) of brimonidine tartrate.

3. The composition of claim 1 which comprises 0.1% (w/v) of brimonidine tartrate.

4. The composition of either of claim 3 wherein the carboxymethyl cellulose enhances the solubility of brimonidine tartrate in solution.

5. The composition of claim 3 further comprising boric acid.

6. The composition of claim 3 further comprising sodium borate.

7. The composition of claim 3 further comprising hydrochloric acid.

8. The composition of claim 7 wherein the composition has a ph of 7.4-8.0.

9. The composition of claim 1 , wherein the composition comprises 0.1% w/v brimonidine tartrate, 0.5% w/v carboxymethyl cellulose, 0.005% w/v oxy-chloro preservative, 0.6% w/v boric acid, 0.045% w/v sodium borate decahydrate, 0.37% w/v sodium chloride, 0.14% w/v potassium chloride, 0.006% w/v calcium chloride dihydrate, 0.006% w/v magnesium chloride hexahydrate, and water.