IP Library › Granted Patent US 9,585,939
Granted Patent B2
US 9,585,939 · App. 15/049,953 · Granted Mar 7, 2017

Protection against apoptosis from ionizing radiation

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Quick Facts
Patent No.
US 9,585,939
App. No.
15/049,953
Granted
Mar 7, 2017
Kind
B2
Abstract

The use and screening of modulators of apoptosis is disclosed. The modulators may be, for example, modulator of NF-κB activity. The modulators may be used, for example, in the treatment of NF-κB-mediated diseases, conditions, and injuries.

Claims (5)

1. A method of protecting a mammal from ionizing radiation induced apoptosis tissue damage comprising administering to a mammal in need thereof a composition comprising an effective amount of Salmonella flagellin.

2. The method of claim 1 wherein the ionizing radiation is sufficient to cause gastrointestinal syndrome or hematopoietic syndrome.

3. The method of claim 1 wherein the composition is administered in combination with a radioprotectant.

4. The method of claim 3 wherein the radioprotectant is an antioxidant.

5. The method of claim 4 wherein the antioxidant is selected from the group consisting of amifostine and vitamin E.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 23, 2016
From: GUDKOV, ANDREI V.
To: THE CLEVELAND CLINIC FOUNDATION
Reel/Frame 037798/0796 →