Imino compounds for amphoteric liposomes and uses thereof
View Patent ↗The invention concerns lipid assemblies, liposomes having an outer surface comprising a mixture of anionic and cationic moieties; wherein at least a portion of the cationic moieties are imino moieties that are essentially charged under physiological conditions, and their use for serum resistant transfection of cells.
1. A compound comprising the following structure
2. A lipid assembly for transfecting cells comprising a compound of claim 1 and an anionic lipid.
3. A composition comprising a lipid assembly for transfecting cells comprising a compound of claim 1 , wherein the lipid assembly encapsulates an active agent.
4. The composition of claim 3 , wherein the active agent is a nucleic acid or an RNA.
5. A composition according to claim 3 for treating a disease in a human.
6. A method for delivering a nucleic acid to a cell comprising contacting the cell with the composition according to claim 4 .