IP Library › Patent Application 15053360
Patent Application
App. No. 15/053,360

Novel Epitope for Switching to Th17 Cell and Use Thereof

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Quick Facts
Patent No.
US None
App. No.
15/053,360
Abstract

The present invention relates to a novel epitope to convert T cell to type 17 helper T (T H 17) cell. Specifically, the present invention relates to an epitope constituting the 41 st to 50 th amino acids (SEQ ID No. 2) of extracellular domain (ECD) of activation-inducible tumor necrosis factor receptor (AITR), an antibody recognizing the epitope, a polynucleotide encoding the epitope, a polynucleotide encoding the antibody, an expression vector comprising the polynucleotide encoding the epitope or antibody, a transformant introduced with the vector, a composition comprising the antibody for converting T cell to T H 17 cell and a method of conversion for the same, a pharmaceutical composition comprising the antibody for preventing or treating infectious disease, a method for treating infectious disease using the antibody, a composition comprising the antibody for enhancing immunity, and a method for enhancing immunity using the antibody.

Claims (2)

1 . A polypeptide which is an epitope of activation-inducible tumor necrosis factor receptor (AITR), defined as an amino acid sequence represented by SEQ ID No. 2, for converting T cell to type 17 helper T (T H 17) cell.

2 . A polynucleotide encoding the polypeptide of claim 1 .

Assignments (2)
NUNC PRO TUNC ASSIGNMENT Recorded Feb 9, 2017
From: NATIONAL CANCER CENTER
To: EUTILEX CO., LTD.
Reel/Frame 041215/0798 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 9, 2016
From: KWON, BYOUNG SE
To: NATIONAL CANCER CENTER
Reel/Frame 038532/0566 →