IP Library › Patent Application 15055918
Patent Application
App. No. 15/055,918

2-SUBSTITUTED IMIDAZO[4,5-D]PHENANTHROLINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CANCER

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Quick Facts
Patent No.
US None
App. No.
15/055,918
Abstract

The present invention provides 2-substituted imidazo[4,5-d]phenanthroline compounds, which are capable of inhibiting proliferation of one or more renal cancer cells, pancreatic cancer cells, prostate cancer cells, colon cancer cells, leukemia cells, brain cancer/tumour cells or non-small cell lung cancer cells.

Claims (22)

1 .- 17 . (canceled)

18 . A compound of formula (IV):

or a salt or solvate thereof, wherein:

one of R 1 and R 2 , or R 2 and R 3 , or R 3 and R 4 , or R 4 and R 5 , when taken together with the carbon atoms, to which they are attached form a 5 or 6 membered optionally substituted heterocycle, having at least one heteroatom that is N or O,

and remaining of R1 to R5 are independently H, optionally substituted alkyl, or optionally substituted alkoxy.

19 . The compound of claim 18 , wherein one of R 1 and R 2 , or R 2 and R 3 , or R 3 and R 4 , or R 4 and R 5 , when taken together with the carbon atoms to which they are attached, form

and wherein R a and R b are —R c , halo, or —OR d ,

where R c is selected from the group consisting of alkyl, cycloalkyl, heteroalkyl, cycloheteroalkyl, aryl, arylalkyl, heteroaryl and heteroarylalkyl and R d is independently hydrogen or R c .

20 . The compound of claim 18 , remaining of R 1 to R 5 are each H.

21 . The compound of claim 18 , wherein R 2 and R 3 are taken together with the carbon atoms, to which they are attached, form:

and R 1 , R 4 and R 5 are each H.

22 . The compound of claim 18 , wherein R a and R b are halo.

23 . The compound of claim 18 , wherein the compound is:

24 . A pharmaceutical composition comprising a compound according to claim 18 , or a salt or solvate thereof, and a pharmaceutically acceptable carrier.

25 . A pharmaceutical composition comprising a compound of claim 23 or a salt or solvate thereof, and a pharmaceutically acceptable carrier.

26 . A method of inhibiting the proliferation of cancer cells in a subject in need thereof, comprising treating the cancer cells with a compound according to claim 18 .

27 . The method of claim 26 , wherein the cancer cells are in vitro.

28 . A method of treating cancer in a mammal, comprising administering to said mammal an effective amount of a compound according to claim 18 .

29 . The method of claim 26 , wherein the cancer is renal cancer, pancreatic cancer, prostate cancer, colon cancer, leukemia, lymphoma, brain cancer/tumour or non-small cell lung cancer.

30 . The method of claim 26 , wherein the cancer is lymphoma.

31 . The method of claim 28 , wherein the cancer is renal cancer, pancreatic cancer, prostate cancer, colon cancer, leukemia, lymphoma, brain cancer/tumour or non-small cell lung cancer.

32 . The method of claim 31 , wherein the cancer is lymphoma.